Topics
Hematologic diseases
Single dose v two‐dose antenatal anti‐D prophylaxis: a randomised controlled trial
The two-dose schedule currently recommended in Australia provides better protection than a one-dose regimen
Scott W White · Janice C Cheng · Blagica Penova‐Veselinovic · Carol Wang · Melanie White · Bernie Ingleby · Christine Arnold · Craig E Pennell
Antiphospholipid syndrome: a clinical review
Antithrombotic treatment is gold standard and effective
Veronica Mezhov · Julian D Segan · Huyen Tran · Flavia M Cicuttini
Pulmonary embolism: update on diagnosis and management
Pulmonary embolism is a potentially life-threatening condition, mandating urgent diagnosis and treatment
Paul C Kruger · John W Eikelboom · James D Douketis · Graeme J Hankey
Diagnosis and management of heparin‐induced thrombocytopenia: a consensus statement from the Thrombosis and Haemostasis Society of Australia and New Zealand HIT Writing Group
These are the first Australasian recommendations for diagnosis and management of HIT, with a focus on locally available diagnostic assays and therapeutic options
Joanne Joseph · David Rabbolini · Anoop K Enjeti · Emmanuel Favaloro · Marie‐Christine Kopp · Simon McRae · Leonardo Pasalic · Chee Wee Tan · Christopher M Ward · Beng H Chong
Deep vein thrombosis: update on diagnosis and management
The diagnosis of DVT requires a high index of suspicion because symptoms and signs are often non-specific
Paul C Kruger · John W Eikelboom · James D Douketis · Graeme J Hankey
Surface antigen negative hepatitis B infection: the importance of screening before B cell‐depleting therapy
Evidence suggests that appropriate hepatitis B virus (HBV) screening before B cell-depleting therapy is frequently not performed
Sanjivan Mudaliar · Ken Liu · Simone I Strasser
Advances in stroke medicine
Reperfusion therapies for ischaemic stroke have transformed the prognosis for long term disability, but maximising patient benefit requires increased community recognition and faster treatment
Bruce CV Campbell
Biology and therapy of multiple myeloma
Due to the remarkable improvements in the diagnosis and management of myeloma over the past decade, we can look forward to regimens that will allow the eradication of residual disease and result in the cure of myeloma
Douglas E Joshua · Christian Bryant · Caroline Dix · John Gibson · Joy Ho
Reversal of dabigatran with idarucizumab in hyperacute stroke: a new paradigm?
A 68- year- old man presented with hyperacute stroke one hour after symptom onset
Amy Ting · Abhay R Venkat · Yash Gawarikar · Ronak Patel
Updated Australian consensus statement on management of inherited bleeding disorders in pregnancy
Updated statement reflects significant advances in the past decade
Scott Dunkley · Julie A Curtin · Anthony J Marren · Robert P Heavener · Simon McRae · Jennifer L Curnow
New guidelines from the Thrombosis and Haemostasis Society of Australia and New Zealand for the diagnosis and management of venous thromboembolism
The THANZ guideline for the diagnosis and management of VTE has been developed by the VTE Working Group based on up‐to‐date evidence and using an evidence‐based approach. The guideline aims to promote optimal management of VTE. The extended version of the guideline can be found on the THANZ website (www.thanz.org.au/resources/thanz-guidelines).
Huyen A Tran · Harry Gibbs · Eileen Merriman · Jennifer L Curnow · Laura Young · Ashwini Bennett · Chee Wee Tan · Sanjeev D Chunilal · Chris M Ward · Ross Baker · Harshal Nandurkar
Hereditary haemorrhagic telangiectasia
A 52-year-old woman presented with symptomatic iron deficiency anaemia …
Varitsara Mangkorntongsakul · Cecily J Forsyth
Subclavian vein thrombosis with internal jugular vein extension in an Australian rules football player
A 40-year-old female Australian rules football player presented to a rural emergency department with a 3-hour history of swelling and pain in her right upper limb
John WP Wong · Fiona WY Lai · Ian Wilson
Fifty years of RhD immunoglobulin (anti-D) therapy in Australia: celebrating a public health success story
In 2017, Australia celebrated the 50th anniversary of the anti-D program, which uses the plasma of special donors to protect the babies of millions of Australian women
James Thyer · Janet Wong · Amanda Thomson · Barbara Bell · Catherine Hyland · Daniel Challis
Massive oxidative haemolysis and renal failure caused by high dose vitamin C
A 54-year-old man, who was diagnosed with metastatic prostate cancer in March 2016, received first-line treatment with docetaxel and degarelix
Matthew J Rees · Madeleine C Strach · Kate Burbury · Kelly-Anne Phillips
National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the diagnosis and management of atrial fibrillation 2018
Atrial fibrillation is increasing in prevalence and associated with significant morbidity and mortality
David Brieger · John Amerena · John R Attia · Beata Bajorek · Kim H Chan · Cia Connell · Ben Freedman · Caleb Ferguson · Tanya Hall · Haris M Haqqani · Jeroen Hendriks · Charlotte M Hespe · Joseph Hung · Jonathan M Kalman · Prashanthan Sanders · John Worthington · Tristan Yan · Nicholas A Zwar
Reversible pancytopenia caused by severe copper deficiency in a patient with Wilson disease
A 26-year-old woman was referred to the haematologist for evaluation of new onset pancytopenia
Muhajir Mohamed · Anna Johnston · Andrew Maclaine Cross · Archna Sharma
Children as haematopoietic stem cell donors: ethically challenging and legally complex
Clinicians should be aware of the particular physical and psychological risks of haematopoietic stem cell donation in the paediatric setting, and the varying laws between states and territories
Shih-Ning Then · Ian H Kerridge · Michael Marks
Sarcoidosis: a state of the art review from the Thoracic Society of Australia and New Zealand
Despite recent advances in our knowledge of sarcoidosis, it remains a diagnosis of exclusion
Hasib Ahmadzai · Shuying Huang · Chris Steinfort · James Markos · Roger KA Allen · Denis Wakefield · Margaret Wilsher · Paul S Thomas
Emerging infectious disease agents and blood safety in Australia: spotlight on Zika virus
To the Editor: I found the article by Kiely and colleagues1 very interesting. The authors concluded that “it should be noted that a relatively small number of imported ZIKV [Zika virus] infections have been reported in Australia, there have been no reported cases of local ZIKV transmission, and the geographical distribution of the potential ZIKV mosquito vector in Australia (Aedes aegypti) is limited to northern Queensland,” and that “at present, ZIKV represents a low risk to blood safety in Australia.”1 Indeed, Kiely and colleagues may be correct in their statement. Nevertheless, without supportive evidence, it seems too soon to draw a conclusion. The estimation of the risk or possibility of transfusion-transmitted ZIKV infection in each setting may be based on mathematical modelling with reference to risk of transmission of other arboviruses in that setting. A good example is the previous report on the estimated risk of transfusion-transmitted ZIKV infection in Thailand.2 However, the lack of reports on ZIKV transmission does not mean that the problem does not exist; many patients with ZIKV infection are asymptomatic and can be easily missed.3
Viroj Wiwanitkit
Emerging infectious disease agents and blood safety in Australia: spotlight on Zika virus
In reply
Philip Kiely · Erica M Wood · Allen C Cheng
The value of novel oral anticoagulants in rural Australia
The new agents offer important safety and convenience advantages, but need to win the confidence of clinicians and patients
Ke Xu · Noel C Chan · John W Eikelboom
The impact of non-vitamin K antagonist oral anticoagulants (NOACs) on anticoagulation therapy in rural Australia
NOACs could improve the convenience of anticoagulation therapy for patients in remote locations
Jamie W Bellinge · Jarrad J Paul · Liam S Walsh · Lokesh Garg · Gerald F Watts · Carl Schultz
Livedo racemosa
A 30-year-old woman presented with progressive, symmetrical, jagged and reticulate erythema and hyperpigmentation of the lower legs consistent with livedo racemosa
Deshan F Sebaratnam · Nita Agar
Improving the safety of breast implants: implant-associated lymphoma
A likely causal link between breast implants and lymphoma highlights the importance of a prospective registry
Ingrid Hopper · Susannah Ahern · John J McNeil · Anand K Deva · Elisabeth Elder · Colin Moore · Rodney Cooter