Volume 223 · Issue 10 · Supplement

We stand at the beginning of the next bioscience revolution in asthma

Anthony Flynn · Wendy Edmondson · Alan James · Caroline Lodge · Vanessa M McDonald · Christine R Jenkins · John Blakey · Gary P Anderson

Cures for asthma will require a sustained, decade-long program of discovery science partnered with best clinical expertise

Gary P Anderson · Anthony Flynn · Phil G Bardin · John D Blakey · Shyamali C Dharmage · Paul Foster · Peter G Gibson · Adam Jaffe · Alan James · Christine R Jenkins · Sundram Sivamalai · Peter D Sly · Guy B Marks · Vanessa M McDonald · Judy Wetttenhall

Cure can be defined as the extended absence of disease activity without treatment and minimal likelihood of relapse

Dennis Thomas · Vanessa M McDonald · Peter G Gibson · Richard Y Kim

A combine-to-cure approach is essential, simultaneously preventing harmful exposures and directed at the underlying biological mechanisms

Denby J Evans · Peter D Sly · Paul Foster · Chantal Donovan

Using novel statistical and artificial intelligence techniques to interrogate combined cohort datasets will open the door to drug discovery

Caroline Lodge · Xin Dai · Ingrid A. Laing · Michael P Menden · Anthony Flynn · Gary P Anderson · Sarath Ranganathan · Shyamali C Dharmage

Elucidating the molecular architecture of disease and focusing on earlier, more malleable biological features will lead to cures

Aowen Zhuang · Dennis Thomas · Caroline Lodge · Jane E Bourke · John W Upham · Vanessa M McDonald · Peter AB Wark · Gary P Anderson

Combining new technologies with artificial intelligence will enable more accurate disease prediction, precision diagnoses, and personalised treatments

Sara Quon · Timothy M Johanson · Ridhima Wadhwa · Alen Faiz · Anthony Flynn · Gary P Anderson · Amanda J Cox · Nicholas P West · Michael P Menden · Rhys S Allan