- Antiphospholipid syndrome is characterised by recurrent thrombosis (arterial, venous, microvascular) and/or pregnancy complications in the presence of persistent antiphospholipid antibodies (lupus anticoagulant, anti‐β2‐glycoprotein 1 and anticardiolipin).
- It can be a primary disease or associated with another autoimmune disease (especially systemic lupus erythematosis).
- Testing for antiphospholipid antibodies should be considered in patients < 50 years of age with unprovoked venous or arterial thromboembolism, thrombosis at unusual sites or pregnancy complications.
- The mainstay of treatment is antithrombotic therapy and recommendations vary based on arterial, venous or pregnancy complications.
- If associated with systemic lupus erythematosis, hydroxychloroquine is recommended both as primary and secondary prophylaxis.
- Antithrombotic treatment is gold standard and effective.
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