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Psychiatry

Toxicology Research letter 1 July 2026 Open Access

Self-Poisoning With Prazosin and Its Off-Label Use in Australia, 2014–2024: Analysis of NSW Poisons Information Centre Data

NSW Poisons Information Centre data identified 1030 deliberate prazosin self-poisonings over 11 years, rising from 13 to 170 per year (2014–2024). Young women predominated, likely due to expanded off-label (but accepted) psychiatric use of prazosin. Better evidence on benefits of off-label use is needed to justify increasing risks.

Olivia B. E. Lal, Nicholas A. Buckley, Rose Cairns

Mja2 70242

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