Mja cover 061117

Issues

Volume 207 Issue 9

6 November 2017

News

6 November 2017 Free

News briefs

“Egg-timer” tests don’t predict fertility in older women In older women of reproductive age, biomarker levels that indicate diminished ovarian reserve were not associated with reduced fertility, according to a study published by JAMA. Anti-Müllerian hormone, early follicular phase follicle-stimulating hormone (FSH), and inhibin B are collectively regarded as biomarkers of ovarian reserve; however, their ability to predict reproductive potential is uncertain. Between April 2008 and March 2016, researchers from the University of North Carolina conducted a prospective time-to-pregnancy cohort study, to determine the extent to which biomarkers of ovarian reserve were associated with reproductive potential. The Time to Conceive study included 981 women aged 30–44 years without a history of infertility who had been trying to conceive naturally for 3 months or less. A total of 750 women provided blood and urine samples and were included in the analysis. After adjusting for age, body mass index, ethnic background, current smoking status, and recent hormonal contraceptive use, the researchers found that neither low serum anti-Müllerian hormone levels nor high serum FSH levels were associated with reduced fecundability (probability of conception in a given menstrual cycle), nor were they associated with a lower cumulative probability of conceiving within 6 or 12 cycles of pregnancy attempt. Urinary FSH and early follicular phase inhibin B levels were also not predictive of fertility outcomes. https://jamanetwork.com/journals/jama/fullarticle/2656811 Ten times as many overweight children than in 1975 The number of obese children and adolescents aged 5–19 years worldwide has increased more than tenfold over the past four decades, from an estimated 5 million girls in 1975 to 50 million in 2016, and from 6 million to 74 million boys, according to a new analysis of trends in child and adolescent obesity in 200 countries published in The Lancet. The prevalence of child and adolescent obesity — defined by a body mass index (BMI) more than two standard deviations (SDs) above the age- and sex-specific median level of the World Health Organization growth reference — was 30% in parts of Polynesia, and 20% or higher in the United States, in some Middle Eastern and north African countries (including Egypt, Kuwait, Qatar and Saudi Arabia), and in the Caribbean (Bermuda and Puerto Rico). Overall, the global prevalence of child and adolescent obesity increased from 0.7% to 5.6% for girls, and from 0.9% to 7.8% for boys. In addition, 213 million children and adolescents were in the overweight range (one to two SDs above the median). Despite the increase in child and adolescent obesity, more children are moderately or severely underweight (more than two SDs below the median level): 75 million girls and 117 million boys in 2016. Almost two-thirds of the world’s children and adolescents who are moderately or severely underweight lived in south Asia. The study, led by Imperial College London (UK) and the World Health Organization, brought together data from 2416 studies involving 128.9 million participants worldwide, including 31.5 million children and adolescents aged 5–19 years in 200 countries. Average child and adolescent BMI levels have been consistently high in many high income countries in North America and Europe, but have plateaued in recent years, while average BMI among adults continues to rise. In contrast, the rise in mean BMI has accelerated in many parts of Asia. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32129-3/fulltext

Cate Swannell

Perspectives

Medical education

Ethics and law

Editorials

Research

Research letter

Systematic review

Narrative review

Letters

Environmental health 6 November 2017 Free

Vaccine myopia: adult vaccination also needs attention

To the Editor:I read with interest the call by Menzies and colleagues1 for revitalised efforts to vaccinate a higher proportion of the adult Australian population against common infectious diseases. At present, the aim of the adult component of the National Immunisation Program is to protect against Streptococcus pneumoniae and the two viruses that cause influenza and herpes zoster — all prevalent pathogens in our environment. In addition to infections derived in Australia, adults are more likely than children to be the focus of imported cases of infection. Exposure of adults to, for instance, tropical infectious diseases, including those transmitted by biting insects (ie, dengue, yellow fever, chikungunya and Zika viruses, malaria, etc), will be far greater than that of juveniles. This is because adults have more reason to travel overseas and typically undertake more trips than children do.2 Vaccine uptake among travellers is mixed, and there are groups that are not sufficiently vaccinated, including people who travel overseas to visit friends and relatives (VFR). These so-called VFR travellers are more likely to consider themselves at low personal risk or threat when travelling to their country of origin, stemming from a sense of familiarity with the destination country and its infectious disease risks.3 Cultural beliefs and language barriers are also important factors associated with suboptimal uptake of pre-travel advice among VFR travellers. While infants accompany their parents for holidays and to visit family abroad, intercontinental travel for business and educational opportunities is largely restricted to adults.4 For typical short stay business trips, rather than for holidays lasting an extended period, it is tempting to neglect being up to date with vaccinations.2 In this instance, for the busy business flyer — often a last-minute traveller — the risk aversion to illness may be suppressed by avoidance of the perceived hassle of immunisation. Travel acts as a vector for spread of infection and many outbreaks are imported into Australia through overseas trips; nevertheless, travellers frequently neglect to seek pre-travel health advice.5 Improving rates of travel vaccination, especially in adults, is one area of focus that may help infectious disease control efforts nationally.

Andrew W Taylor-Robinson

Environmental health 6 November 2017 Free

No Jab, No Pay and vaccine refusal in Australia: the jury is out

To the Editor:While vaccine refusal is but one contributor among several to failures of vaccine-preventable disease control, as stated by Beard and colleagues,1 there are important ethical aspects of vaccine refusal. Intentionally opting out of vaccination imposes risks on others, and policies allowing some to opt out weigh their freedom to do so against the rights of others not to be harmed by vaccine-preventable diseases.2 In particular, people who cannot be safely vaccinated (eg, infants) or maintain immunity (eg, the immunosuppressed) are at increased risk of severe disease — including death — and depend on the immunity of others.2 It is true that herd immunity has no “magic threshold”:1 even with high population vaccination levels, severe harm may be caused when just one unvaccinated person has contact with an infectious person and then a vulnerable person. The death of an immunosuppressed woman from measles pneumonitis in the state of Washington, United States, in 2015 is a case in point.3 Tighter legislation on universal vaccination does not unfairly target vaccine refusal. Indeed, Victorian No Jab, No Play legislation has a general objective: “to increase immunisation rates for young children,”4 which applies equally to people who have unintentionally failed to vaccinate and those who intentionally opt out due to hesitancy or refusal. Policy should make vaccination the norm and aim for the highest possible coverage. Moreover, while we should revise financial penalties if they unfairly burden poor families (while the wealthy may pay to opt out), policy should, in some way, recognise that conscientious objection to vaccination has consequences for others.5 Measles outbreaks are correlated with vaccine refusal6 and lead to significant social costs, which Australia may avoid if high levels of vaccination are maintained. Though the true epidemiology is certainly more complex, if measles vaccination leads to immunity in 99% of vaccine recipients, and 95% of people are vaccinated,1 the population level of immunity would be 94.05%. Threshold concepts have limitations, but whether this is “comfortably exceeding” 94%,1 or perilously close to recurrent measles outbreaks — which impose avoidable risks of harm on others — is a matter for debate.

Euzebiusz Jamrozik

Careers

6 November 2017 Free

Around the universities and research institutes

The recipients of Citations for Outstanding Contributions to Student Learning, through the Australian Awards for University Teaching have been announced and health and medical educators have featured heavily. From the Australian National University, Professor Emily Banks was cited for outstanding leadership within epidemiology and public health and for the development of an innovative team and systems-based approach to student supervision. From Charles Sturt University, Dr Louise Pemberton was cited for facilitating success in biomedical science through the Science Learner Engagement with Great Outcomes creative learning activities. From the University of NSW, Dr Louisa Smith was cited for the design, development and implementation of research-led accessible and innovative teaching and learning resources in the field of disability studies. From the University of Sydney, the Health Collaboration Challenge Team was cited for innovation in interprofessional learning for health students using videography and peer assessment. From Flinders University, Flinders NT was cited for facilitating quality workplace-based supervision practice for health professionals in remote locations through development and provision of context-responsive inter-professional training and peer review resources. From the University of WA, Associate Professor Denese Playford was cited for developing and leading innovative medical education programs using transformative learning experiences to inspire and prepare students to serve rural and disadvantaged people. From Curtin University, Associate Professor Janet Beilby was cited for the creation of internationally recognised, innovative, work-integrated learning resources to ensure industry-ready health science graduates, capable of delivering world-class client care. From Bond University, Assistant Professor Christian Moro was cited for developing innovative technology-enhanced curriculum, experiential visualisation tools and resources that positively impact medical and biomedical students’ learning and application of physiology and anatomy. From the Queensland University of Technology, Professor Fiona Naumann was cited for sustained leadership in transitioning Exercise Physiology towards competency-based education through curriculum innovation, scholarly inquiry and strategic collaborations with the profession and universities. From the University of Queensland, Dr Lisa Fitzgerald was cited for challenging and supporting public health students through a learning journey to gain a deeper understanding of the social determinants of health. From Monash University, Dr Julia Choate was cited for developing, implementing and evaluating student-centred active learning strategies that engage biomedical, medical, nutrition and science undergraduates and enhance their learning of physiology. From the University of Melbourne, Dr Jason Ivanusic was cited for leadership in anatomy teaching that provides innovative, engaging and internationalised learning experiences for students of biomedical sciences. Also from the University of Melbourne, Ms Shawana Andrews was cited demonstrating sustained excellence in developing an Indigenised curriculum as a lecturer in Indigenous health within the health sciences. https://docs.education.gov.au/system/files/doc/other/ed17-0285_aaut_booklet_internals_04.pdf Professor Jennifer Martin, director of Griffith University’s Institute for Drug Discovery has been awarded Bragg Membership of the Royal Institution of Australia at a ceremony attended by Prince Andrew, the Duke of York. Professor Martin’s research focuses on protein structure and function in health and disease and the application of structure-based approaches to the design and development of new drugs. Professor Martin has previously been awarded the inaugural ARC Australian Laureate Fellowship, the ASBMB Roche Medal, the Queensland Smart Women Smart State Research Scientist Award, and the Women in Biotech Outstanding Achievement Award. She is the President of the Asian Crystallography Association, a former President of the Society of Crystallographers in Australia and New Zealand, and a former chair of the National Committee for Crystallography of the Australian Academy of Science. Professor Martin was a Foundation Member of the Australian Academy of Science’s Science in Australia Gender Equity committee, charged with addressing gender equity in STEMM. https://riaus.org.au/wp-content/uploads/2017/09/170920-Media-Release-New-Inductees-of-Prestigious-Bragg-Membership-website.pdf

Next Issue Volume 207 Issue 10

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Mja cover 201117
News 20 November 2017 Free

News briefs

Cate Swannell

Perspectives 20 November 2017 Free

The future of health care in Australia

The Hon Catherine King

Perspectives 20 November 2017 Free

Challenging how tobacco is sold in Australia

Becky Freeman

Perspectives 20 November 2017 Free

Legal does not mean unaccountable: suing tobacco companies to recover health care costs

Ross MacKenzie · Eric LeGresley · Mike Daube

Previous Issue Volume 207 Issue 8

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Mja cover 161017
News 16 October 2017 Free

News briefs

Cate Swannell

Perspectives 16 October 2017 Free

The rationale for action to end new cases of rheumatic heart disease in Australia

Rosemary Wyber · Judith M Katzenellenbogen · Glenn Pearson · Michael Gannon

Medical education 16 October 2017 Lessons from practice Free

Neonatal tinea corporis

Lachlan J Warren · Dev Tilakaratne · Rakesh Seth

Medical education 16 October 2017 Clinical skills Free

Recognising severe cutaneous adverse drug reactions

Paul Chee

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