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Issues

Volume 208 Issue 2

5 February 2018

News

5 February 2018 Free

News briefs

Benefits of healthy diet greater for those at high genetic risk of obesity US research published in the BMJ has shown that the benefits of sticking to a healthy diet to prevent long term weight gain are greater in people at high genetic risk for obesity than in those with lower risk. The researchers analysed data from two large studies of US health professionals – 8828 women in the Nurses’ Health Study and 5218 men from the Health Professionals Follow-up Study from 1986 to 2006. Genetic risk score was calculated on the basis of 77 gene variants known to influence body mass index. Changes in body mass index and weight were calculated every 4 years. Changes in dietary patterns were also assessed every 4 years with three diet quality scores: the Alternate Healthy Eating Index 2010 (AHEI-2010), Dietary Approach to Stop Hypertension (DASH), and Alternate Mediterranean Diet (AMED). These diets are all rich in fruit and vegetables, nuts and whole grains, and low in salt, sugary drinks, alcohol and red and processed meats. After 20 years’ follow-up, the researchers found that improving adherence to the AHEI-2010 and DASH was associated with decreases in body mass index and body weight, and that the effect was more prominent in people at high genetic risk for obesity than those with low genetic risk. In addition, they noted that “the genetic risk of weight gain is attenuated by improving adherence to these healthy dietary patterns”. No clear interaction pattern was found for AMED. The authors pointed out that this was an observational study, so no firm conclusions could be drawn about cause and effect. Nevertheless, they said that their findings “highlight the importance of improving adherence to a healthy diet in the prevention of weight gain, particularly in people genetically predisposed to obesity”. http://www.bmj.com/content/360/bmj.j5644 http://www.bmj.com/content/360/bmj.k7 Genetic risk could guide prostate screening A new score for predicting a man’s genetic risk of developing aggressive prostate cancer could help guide decisions about who to screen and when, according to research published in the BMJ. The researchers used data from an international study collaboration (the PRACTICAL consortium) to develop and test a genetic tool for predicting age of onset of aggressive prostate cancer and to guide decisions about who to screen and at what age. They analysed more than 200 000 gene variants (single nucleotide polymorphisms, or SNPs) in 31 747 men of European ancestry with and without prostate cancer, and identified 54 SNPs associated with increased risk of prostate cancer. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diagnosis of aggressive prostate cancer in the form of a hazard score. To validate the final model, it was applied to data from an independent clinical trial of 6411 men. The hazard score was a highly significant predictor of age at diagnosis of aggressive cancer; men in the top 2% of the score had an almost three-fold greater risk for aggressive prostate cancer than men with average risk. The researchers commented that the score is representative of a man’s fixed genetic risk, so “it can be calculated once, long before onset of prostate cancer, and substantially inform the decision of whether he should undergo screening”. They acknowledged some study limitations, and could not rule out the possibility that other, unmeasured factors may have influenced their results. Nevertheless, they said these results “add to existing data as further evidence that genetic features can predict risk of prostate cancer”. http://www.bmj.com/content/360/bmj.j5757

Cate Swannell

Perspectives

Medical education

Book/media/app review

Editorials

Research

Systematic review

Position statement summary

Respiratory disease 20 November 2017 Free

Diagnosis and management of idiopathic pulmonary fibrosis: Thoracic Society of Australia and New Zealand and Lung Foundation Australia position statements summary

Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with debilitating symptoms of dyspnoea and cough

Helen E Jo* · Jyotika D Prasad* · Lauren K Troy · Annabelle Mahar · Jane Bleasel · Samantha J Ellis · Daniel C Chambers · Anne E Holland · Fiona R Lake · Gregory Keir · Nicole S Goh · Margaret Wilsher · Sally de Boer · Yuben Moodley · Christopher Grainge · Helen M Whitford · Sally A Chapman · Paul N Reynolds · David Beatson** · Leonie J Jones · Peter Hopkins · Heather M Allan · Ian Glaspole*** · Tamera J Corte***

Research letter

Narrative review

Letters

Emergency medicine 5 February 2018 Free

Burnout in intensive care

To the Editor:The recent tragic suicides of young doctors have highlighted concerns regarding the welfare of trainees in our profession. The Trainee Committee of the College of Intensive Care Medicine of Australian and New Zealand (CICM) met in Melbourne in March 2017, and the recent results of the survey1 into bullying and harassment, in addition to the deaths of several junior medical officers to suicide, provided for a solemn meeting. The committee wants to highlight the factors that adversely affect intensive care medicine trainees: bullying, discrimination and sexual harassment;1 staffing and intensity as, while patients’ needs are more complex, staffing has not increased with this intensity of practice; rapid response teams, which are often under-resourced, poorly trained and undersupported; and poor workforce planning and tenuous future job security, compelling junior doctors to pursue increased non-clinical commitments without an allocated time to do so. A consequence of these factors is burnout, which disproportionately affects intensivists and is an increasingly significant risk in trainees.2 Changes in work practices, severity of illness, increased demand for limited resources and increasing intensive care unit size — problems that have recently been addressed by Corke3 — have all played a part in burnout rates. The Trainee Committee welcomes the approach of the CICM to tackle these issues.4 The college is steadfast in its zero tolerance to bullying, discrimination and harassment, and remains committed to fair and equitable access to training. The college also values the need for a reasonable balance between provision of clinical services and time for professional development, and recognises the importance of work–life balance, including part-time training and the provision of parental and other forms of leave. However, the CICM has limited ability to enforce these needs at hospital level. Finally, the CICM embraces rapid response teams, recognising the importance of an appropriately supported service, but hospitals need to respond to this need, and lack of planning and matching training with lifetime workforce demands have to be a priority for the government at all levels. Our specialty will change significantly in the next decade or so. We chose intensive care because we enjoy the work we do and find the challenge it provides rewarding. We must ensure that the next generation of intensivists can meet this challenge too.

Alun T Ellis · Sandra Lussier · Sarah A Yong

Hematologic diseases 5 February 2018 Free

Emerging infectious disease agents and blood safety in Australia: spotlight on Zika virus

To the Editor: I found the article by Kiely and colleagues1 very interesting. The authors concluded that “it should be noted that a relatively small number of imported ZIKV [Zika virus] infections have been reported in Australia, there have been no reported cases of local ZIKV transmission, and the geographical distribution of the potential ZIKV mosquito vector in Australia (Aedes aegypti) is limited to northern Queensland,” and that “at present, ZIKV represents a low risk to blood safety in Australia.”1 Indeed, Kiely and colleagues may be correct in their statement. Nevertheless, without supportive evidence, it seems too soon to draw a conclusion. The estimation of the risk or possibility of transfusion-transmitted ZIKV infection in each setting may be based on mathematical modelling with reference to risk of transmission of other arboviruses in that setting. A good example is the previous report on the estimated risk of transfusion-transmitted ZIKV infection in Thailand.2 However, the lack of reports on ZIKV transmission does not mean that the problem does not exist; many patients with ZIKV infection are asymptomatic and can be easily missed.3

Viroj Wiwanitkit

Adherence to diabetic eye examination guidelines in Australia: the National Eye Health Survey

To the Editor: Retinal screening is crucial to the prevention of vision loss from diabetic retinopathy. The recent National Eye Health Survey highlighted a gap in screening rates between Indigenous Australians (aged ≥ 40 years) and non-Indigenous Australians (aged ≥ 50 years),1 providing a foundation on which to target future eye health services. While acknowledging the budgetary and logistical constraints of such a large-scale study, we are concerned that another at-risk group — younger adults with type 2 diabetes who are aged 18–49 years — was not included in the National Eye Health Survey. The past two decades have seen a global increase in the incidence of type 2 diabetes in youth and young adults, with younger age being an independent risk factor for the development of diabetic retinopathy.2 In Australia, about 130 000 people with type 2 diabetes who are aged < 50 years are registered on the National Diabetes Services Scheme.3 However, there are no population-level data available regarding retinal screening rates in this age group. A decade ago, a survey of young Australian adults with type 2 diabetes (aged 16–35 years) reported a 55% retinal screening rate.4 Given the small, self-selected sample, this is likely an overestimate and compares unfavourably with the non-Indigenous rate of 78% reported for adults aged ≥ 50 years in the National Eye Health Survey.1Moreover, our qualitative research has shown that young adults aged 18–39 years who have type 2 diabetes face different psychosocial challenges and barriers to retinal screening compared with their older counterparts aged ≥ 40 years.5 Younger adults with type 2 diabetes require targeted, tailored intervention, which can only be provided if accurate, population-level data are available for this group. As Foreman and colleagues1 acknowledge, diabetic retinopathy is the leading cause of vision loss in working age adults — a situation with potential for considerable social and economic burden. The absence of current eye examination data for younger Australians with type 2 diabetes increases the risk that their needs will be neglected in future evidence-based policy and program delivery initiatives. We urge the Australian Government and other stakeholders to extend future population-level surveys (and other research and policy initiatives) to include all adults with diabetes.

Amelia J Lake · Jessica L Browne · Jane Speight

Careers

Next Issue Volume 208 Issue 3

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Mja cover 190218
News 19 February 2018 Free

News briefs

Cate Swannell

Perspectives 19 February 2018 Free

Choosing Wisely Australia: changing behaviour in health care

Robyn Ann Lindner

Perspectives 19 February 2018 Free

Compassion and evidence in prescribing cannabinoids: a perspective from the Royal Australasian College of Physicians

Jennifer H Martin · Yvonne Bonomo · Adrian DB Reynolds

Previous Issue Volume 208 Issue 1

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Cover image
News 15 January 2018 Free

News briefs

Cate Swannell

Perspectives 15 January 2018 Free

Investing in men’s health in Australia

James A Smith · Mick Adams · Jason Bonson

Perspectives 11 December 2017 Free

Regulating e-cigarettes in Australia: implications for tobacco use by young people

Luke Wolfenden · Emily Stockings · Sze Lin Yoong

Medical education 15 January 2018 Key research skills Free

Distributions and what to do when they are non-normal

Alan Taylor

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