Article Types

Letters

Notifying a doctor of a first hypoglycaemic episode is associated with a lower rate of recurrence among inpatients with diabetes

To the Editor: Hypoglycaemia is a common problem in inpatients with diabetes and is associated with morbidity and mortality.,2 We conducted a retrospective single-centre cohort study to evaluate the management (notifying a doctor and taking appropriate preventive actions, defined as altering the hypoglycaemic agent that led to the event or commencing dextrose in appropriate cases by the doctor) of the first hypoglycaemic episode and its ...

Dilantha T De Alwis · Suresh Varadarajan · Kwang Lim

Letters 3 February 2014 Free

A computer-based task management system for junior medical officers during after-hours shifts

To the Editor: After-hours communication of tasks between nursing staff and junior medical officers (JMOs) traditionally uses paper lists, whiteboards, face-to-face requests and frequent paging, regardless of task urgency.1,2 This fragments workflow, which increases cognitive demand and the risk of errors.3-5 Computer-based task allocation systems, still in their infancy, have not been objectively evaluated. The aim of our study was to determine whether using a ...

Nicholas J Whitehead · O’Neil N Maharaj · Michael Agrez

13 10884

An update of consensus guidelines for warfarin reversal

To the Editor: The recently updated warfarin reversal guideline recommends prothrombin complex concentrate (PCC) dosing based on international normalised ratios (INRs), rather than fixed dosing.1 While achieving a target INR may be made more likely, this may be inconsequential clinically.2 The reasons are these. The relationship between vitamin K-dependent clotting factor levels and INR or bleeding is uncertain. As INR increases above 5.0, these levels decline ...

Krishna G Badami

13 10271

An update of consensus guidelines for warfarin reversal

In reply: Badami suggests that international normalised ratio (INR)-based prothrombin complex concentrate (PCC) dosing for warfarin reversal may not be clinically useful and is cumbersome to use. We agree that the INR variably reflects factor II, VII, IX and X activity in patients on warfarin therapy. However, the INR is a rapid, valid and readily available test, and an INR-based PCC dosing regimen provides guidance ...

Huyen A Tran · Sanjeev D Chunilal · Huy Tran

13 10685
Pharmacology Letters 3 February 2014 Free

Pharmacometrics: an underused resource in Australian clinical research

To the Editor: Pharmacometrics is an emerging field in Australia, with use in a wide range of therapeutic areas including cardiovascular disease, critical patient care, diabetes and paediatrics.1-4 The results of pharmacometric analyses are often referred to in Therapeutic Goods Administration-approved product information; however, for many clinicians, pharmacometrics remains a mysterious area of research. Therefore, we seek to promote the discipline of pharmacometrics in clinical ...

Vidya Perera · Michael J Dolton · Andrew J McLachlan · Vaughan J Carr · Richard O Day

Letters 3 February 2014 Free

The after-life of drugs: a responsible care initiative for reducing their environmental impact

To the Editor: It is common for unwanted and expired medicines to be disposed of through general waste or, as raised recently by Fisher and colleagues, into the sewage system.1 These practices adversely affect not only the environment, but also social and economic determinants of health. For example, medicines discarded in household bins may be accessible to unintended recipients including children, increasing the risk of ...

Phillip J Bergen · Simon E Appel

13 11267
Women's health Letters 3 February 2014 Free

Unexplained variation in hospital caesarean section rates

To the Editor: Lee and colleagues assessed the hospital caesarean section (CS) rates among hospitals in New South Wales according to the Robson 10-group classification. They identified the 20th centile CS rate for each group.1 These data could be used in Australian maternity services to reduce CS rates and potentially increase the quality of care. Monitoring the quality of care in maternity services has been difficult ...

Rick J Fielke

13 11200
Women's health Letters 3 February 2014 Free

Unexplained variation in hospital caesarean section rates

In reply: We thank Fielke for his interest in our article.1 Our study used the 20th centile method of the Australasian clinical indicator report on obstetrics, conducted by the Australian Council on Healthcare Standards (ACHS).2 The ACHS defines the 20th centile as a “best practice rate” that is potentially achievable and uses it to identify and prioritise clinical areas in which research and quality improvement ...

Yuen Yi (Cathy) Lee · Christine L Roberts · Jillian A Patterson

13 11312
Infectious diseases Letters 3 February 2014 Free

Risk factors for recurrent Mycobacterium ulcerans disease after exclusive surgical treatment in an Australian cohort

To the Editor: O’Brien and colleagues report high rates of recurrence of Mycobacterium ulcerans disease after surgery without adjuvant antibiotics.1 In the other major Australian endemic focus for M. ulcerans, the Daintree region of far north Queensland (where it is known as Daintree ulcer), nearly all of 92 confirmed cases between 1964 and 2008 were treated with surgery alone, with 10 recurrences.2 In 2011, there was an outbreak of 65 confirmed cases. ...

Christina M Steffen

13 10780
Infectious diseases Letters 3 February 2014 Free

Risk factors for recurrent Mycobacterium ulcerans disease after exclusive surgical treatment in an Australian cohort

In reply: We thank Steffen for reporting her and her colleagues’ experience with surgical management of Mycobacterium ulcerans disease in the Daintree region of far north Queensland. We note she reports lower recurrence rates after surgical treatment alone than in our study from Victoria’s Bellarine Peninsula (8%–11% v 32%).1,2 As older age may increase recurrence risk, this difference in rates may be influenced by the higher ...

Daniel P O’Brien · Anthony McDonald · Peter Callan

13 10963

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