Issues
Volume 219 Issue 4
Editor’s choice
Current debates and research in cardiovascular medicine
The Medical Journal of Australia regularly publishes articles related to cardiovascular diseases (CVDs). Although there has been a reduction in total burden due to coronary heart disease over time among Indigenous and non‐Indigenous Australians,1,2 CVDs remain the leading cause of death and disability. In 2019, around 18 million people died from CVDs; of these deaths, heart attack and stroke were the most common underlying causes.3 In the Australian Burden of Disease Study 2022, coronary heart disease was the leading cause of burden of disease for every reference year and contributed to most burden among men and among those aged 45 years and over,1 and among Indigenous Australians.2 In this issue of the MJA, we collate current debates and research in cardiovascular medicine. According to evidence‐based Australian guidelines published in 2016, management of acute coronary syndromes associated with atherosclerotic lesions includes percutaneous coronary intervention where appropriate.4 In this issue, Chew and Zaman discuss the evidence for coronary stenting for chronic stable angina (doi: ). They explore the evidence for treatments for coronary artery disease (CAD) and residual ischaemia in stable CAD. They argue that percutaneous coronary intervention has not shown the same degree of benefit as seen among patients with acute coronary syndromes. Rapid access chest pain clinics exist in Australia and are designed to evaluate people with new onset chest pain. Compared with traditional cardiology clinics, patients with new onset chest pain have been shown to be evaluated more efficiently in rapid access chest pain clinics and had lower rates of subsequent emergency department re‐attendances and adverse cardiovascular events.5 In this issue, Cho and colleagues review the models and experiences of rapid access chest pain clinics in Australia and New Zealand (doi: ). They find that rapid access chest pain clinics are safe and improve hospital efficiency and costs. They conclude that “despite variations in rapid access chest pain clinic models, there are limited data to determine the most effective approach. Developing a national framework could be beneficial to provide sites with evidence, possible models, and business cases. Multicentre data analysis could enhance understanding and monitoring of the service.” Prevention of CVD, including recurrence of adverse events, requires determining a patient's level of risk of developing a CVD in the future. Clinicians are familiar with using the Framingham risk model, and researchers are aware of the limitations of this model when applied to an Australian cohort.6 There is still a gap in the establishment of a robust national cardiovascular risk screening program.7 In this issue, Brown and colleagues review existing risk equations recommended in eleven CVD primary prevention guidelines and assess their suitability for use in Australia (doi: ). This endeavour was commissioned by the National Heart Foundation of Australia on behalf of the Australian Chronic Disease Prevention Alliance to inform recommendations on CVD risk estimation as part of the 2023 update of the Australian CVD risk assessment and management guidelines (https://www.cvdcheck.org.au). The risk equations were assessed against eight selection criteria: development using contemporary data; inclusion of established cardiovascular risk factors; inclusion of ethnicity and deprivation measures; prediction of a broad selection of fatal and non‐fatal CVD outcomes; population representativeness; model performance; external validation in an Australian dataset; and the ability to be recalibrated or modified. Also in this issue, Alexander and colleagues assess a challenge of remote care in a retrospective cohort study conducted in Western Australia (doi: ). This study examines the severity of CAD in people from rural or remote WA referred for invasive coronary angiography (ICA) in Perth and their subsequent management. The authors estimate the cost savings if computed tomography coronary angiography (CTCA) is offered in rural centres as the first line investigation for people with suspected CAD. They find that “were CTCA used locally to determine the need for referral, 527 referrals could have been averted (53%), the ICA:revascularisation ratio would have improved from 2.6 to 1.6, and 1757 metropolitan hospital bed‐days (43% reduction) and $7.3 million in health care costs (36% reduction) would have been saved”. Noting that “many rural and remote Western Australians referred for ICA in Perth have non‐obstructive CAD and can be medically managed”, they conclude that CTCA can be used as a first line investigation in rural centres and could potentially be a cost‐effective strategy for estimating risk in people with suspected CAD and reducing the number of referrals.
Francis Geronimo
Perspectives
Coronary stenting for stable coronary ischaemia: ain't misbehaving, just misunderstood
Choosing therapies well, with the patient’s preference, requires an understanding of the temporal risk profile of coronary artery disease
Derek P Chew · Sarah Zaman
Controversies and dilemmas in the diagnosis of heart failure with preserved ejection fraction
The availability of evidence-based therapies should be seen as a call to action to urgently streamline and unify the diagnosis of HFpEF at the clinical interface
Sandhir B Prasad · David J Holland · John J Atherton
Defibrillator access across Australia: the first step in avoiding a chain of fatality
To survive a sudden cardiac arrest, you need to be in the “right place at the right time”; but should someone’s chance of surviving a sudden cardiac arrest really come down to a roll of the dice?
Elizabeth Paratz · Gregory J Page · Garry LR Jennings
Medical education
Meningococcal B septic shock, reactive pericarditis and public health
A 19-year-old male student with a history of asthma and nut anaphylaxis was taken by ambulance to hospital when he was found unresponsive with vomitus and faecal soiling after one day of lethargy and sore throat
Gary Louie · Romeo Torres · Anthea L Katelaris · Courtney McGregor · Victor Lai · Robert Stevens · Richard Sullivan · Pamela Konecny
Second look diagnosis: dual sinus nodes rhythm in heart transplant patient
A 76-year-old woman presented to a regional hospital with COVID-19-related symptoms
Gabriela Strey
Editorial
Can CTCA provide health care equity for people in rural Australia with coronary artery disease?
Improving diagnostic capabilities in rural areas will require a commensurate increase in clinical decision-making and therapeutic capacity
Taylor Strube · Derek P Chew
Research
Clinical outcomes and health care costs of transferring rural Western Australians for invasive coronary angiography, and a cost‐effective alternative care model: a retrospective cross‐sectional study
Local assessment could improve access to cardiac services in rural centres and reduce the costs associated with sending patients to Perth
Mikhail Alexander · Nick S R Lan · Michael J Dallo · Tom G Briffa · Frank M Sanfilippo · Andrew Hooper · Helen Bartholomew · Loletta Hii · Graham S Hillis · Brendan M McQuillan · Girish Dwivedi · James M Rankin · Abdul Rahman Ihdayhid
The effectiveness of vaccination for preventing hospitalisation with COVID‐19 in regional Queensland: a data linkage study
Maintaining good vaccination coverage effectively reduces the hospital burden associated with COVID-19
Nicolas R Smoll · Mahmudul Hassan Al Imam · Connie Shulz · Robert Booy · Gulam Khandaker
Erratum
Erratum
Allard NL, Canevari J, Haslett N, Cowie BC. Access to oral COVID‐19 antivirals in the community: are eligibility criteria and systems ensuring equity? Med J Aust 2023; 218: 438‐441. https://doi.org/10.5694/mja2.51949
Research letter
Lower urgency care in the emergency department, and the suitability of general practice care as an alternative: a cross‐sectional study
Many ED presentations deemed suitable for GP care based on the AIHW defintion of lower urgency care may be unsuitable
Haomin S Wu · James L Mallows
Narrative reviews
Rapid access chest pain clinics in Australia and New Zealand
A national framework could be beneficial to provide sites with evidence, possible models, and business cases
Kenneth K Cho · John K French · Gemma A Figtree · Clara K Chow · Rebecca Kozor
Evidence supporting the choice of a new cardiovascular risk equation for Australia
Selecting a suitable CVD risk equation for the Australian population
Sinan Brown · Emily Banks · Mark Woodward · Natalie Raffoul · Garry Jennings · Ellie Paige
Letters
Ethical implications of changing the eligibility criteria for the proposed National Lung Cancer Screening Program
To the Editor: The incidence of lung cancer and the five‐year survival of patients diagnosed with lung cancer reflect the social gradient within the Australian society. Most notably, Aboriginal and Torres Strait Islander people are twice as likely to develop lung cancer and half as likely to survive lung cancer.1 Reducing inequity in lung cancer outcomes was a key objective of Cancer Australia when it proposed a National Lung Cancer Screening Program (NLCSP) in 2020, following an enquiry that consulted both medical experts and the broader community.1 The Department of Health sought funding for Cancer Australia's proposed NLCSP in the 2021–2022 Budget but was required by the Department of Finance to refer the proposal to the Medical Services Advisory Committee (MSAC) for review.2 So, when MSAC recently announced its support for the creation of the NLCSP, there was great relief within the lung cancer community. However, what few people seemed to realise was that MSAC had in fact designed, then endorsed, their own alternative model for an NLCSP.3 MSAC's model is fundamentally different to Cancer Australia's model in terms of who is eligible to be screened and, therefore, who can benefit from the screening program. Whereas Cancer Australia intended using an individual's risk of lung cancer (as estimated by the PLCOm2012 risk calculator, which combines sociodemographic data and smoking history),4 MSAC recommended using fixed cut‐offs for age and smoking history. This is problematic in terms of both the evidence base that should have guided MSAC's decision and the ethical implications of the decision. MSAC's approach aligns with the design of historical lung cancer screening trials but it ignores an extensive body of evidence, including both a priori and post hoc analyses of trial data that consistently demonstrate that risk calculators are more efficient than fixed criteria.5 Furthermore, it also ignores international trends in the design of lung cancer screening trials and the implementation of lung cancer screening programs.1 But more importantly, the inevitable consequence of applying MSAC's eligibility criteria will be that fewer socially disadvantaged individuals will be eligible to participate in the NLCSP. This has the potential to exacerbate the existing inequity.
Jonathon B Ryan
Current and emerging medications for the management of obesity in adults
Joshua M Inglis · Ganessan Kichenadasse · Arduino A Mangoni
Current and emerging medications for the management of obesity in adults
Rosalind Walmsley · Priya Sumithran
News
The Medical Journal of Australia supports an Aboriginal and Torres Strait Islander Voice to Parliament
The Medical Journal of Australia has published an editorial, supporting an Aboriginal and Torres Strait Islander Voice to Parliament. New approaches are needed which place Aboriginal and Torres Strait Islander communities at the heart of discussions and decision making about their futures, the editorial said. Authored by the MJA’s Editor-in-Chief Professor Virginia Barbour, the editorial said the MJA had a fundamental role in promoting and supporting what is best for Australian health and practice. “As you form your own positions, we encourage our readership of health practitioners and researchers, and organisations across Australia, to weigh arguments for and against the Voice in an evidence-led manner that centres core public health principles of equity, justice, and recognition of the upstream determinants of health,” Professor Barbour wrote. The health outcomes in Aboriginal and Torres Strait Islander populations during the coronavirus disease 2019 (COVID-19) pandemic provide an outstanding example of how outcomes are best when Aboriginal people have a voice, the editorial said. "Aboriginal Community Controlled Health Organisations coordinated the response from the National Aboriginal Community Controlled Health Organisation down to remote communities,” Professor Barbour wrote. “As a result, the health gap was reversed in the first year of the pandemic, with Aboriginal and Torres Strait Islander populations experiencing six times fewer cases than the non-Indigenous population, and no recorded deaths [here and here].” Current health care structures and processes do not meet the needs of the Aboriginal and Torres Strait Islander population, the editorial said. “New approaches, which place Aboriginal and Torres Strait Islander communities at the heart of discussions and decision making about their futures, are clearly needed,” Professor Barbour said. Many other health and medical organisations have also announced their support for the Voice to Parliament, Professor Barbour wrote, including the Lowitja Institute, the Australian Indigenous Doctors Association, the Australian Medical Association and the Australian Academy of Health and Medical Sciences. The referendum is expected to occur later this year, on a date to be announced.
Sam Hunt
The changing landscape of clinical trials in Australia
Anna Lene Seidler · Melina L Willson · Mason Aberoumand · Jonathan G Williams · Kylie E Hunter · Angie Barba · R John Simes · Angela Webster
Australian National Clinical Evidence Taskforce COVID‐19 drug treatment guidelines: challenges of producing a living guideline
For the COVID‐19 Drug Treatment Panel of the National Clinical Evidence Taskforce
Management of opiate dependence related to dihydrocodeine–sorbitol misuse
Richard CJ Bradlow · Baden Hicks · Temika Mu · Daniel Pham · Michelle Sharkey · Noel Plumley · Dan I Lubman · Shalini Arunogiri
We need to chat about artificial intelligence
Enrico W Coiera · Karin Verspoor · David P Hansen