MJA 217 7 3 Oct cover

Issues

Volume 217 Issue 7

3 October 2022

News

3 October 2022 Free

News briefs

Possible link between artificial sweeteners and heart disease A large study of French adults published in The BMJ suggests a potential direct association between higher artificial sweetener consumption and increased cardiovascular disease risk, including heart attack and stroke. Artificial sweeteners represent a $7200 million global market. Researchers drew on data for 103388 participants (average age, 42years; 80% female) of the web‐based NutriNet‐Santé study, launched in France in 2009 to investigate relations between nutrition and health. Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24‐hour dietary records, and a range of potentially influential health, lifestyle and sociodemographic factors were taken into account. Artificial sweeteners from all dietary sources (beverages, tabletop sweeteners, dairy products, etc) and by type (aspartame, acesulfame potassium, and sucralose) were included in the analysis. In total, 37% of participants consumed artificial sweeteners, with an average intake of 42.46mg/day, which corresponds to approximately one individual packet of tabletop sweetener or 100mL of diet soda. Among participants who consumed artificial sweeteners, mean intakes for lower and higher consumer categories were 7.46 and 77.62mg/day, respectively. During an average follow‐up period of 9years, 1502 cardiovascular events occurred. These included heart attack, angina, angioplasty, transient ischemic attack, and stroke. Total artificial sweetener intake was associated with an increased risk of cardiovascular disease (absolute rate, 346 per 100000 person‐years in higher consumers and 314 per 100000 person‐years in non‐consumers). Artificial sweeteners were more particularly associated with cerebrovascular disease risk (absolute rates, 195 and 150 per 100000 person‐years in higher consumers and non‐consumers, respectively). Aspartame intake was associated with increased risk of cerebrovascular events (186 and 151 per 100000 person‐years in higher consumers and non‐consumers, respectively), while acesulfame potassium and sucralose were associated with increased coronary heart disease risk (acesulfame potassium: 167 and 164 per 100000 person‐years; sucralose: 271 and 161 per 100000 person‐years in higher consumers and non‐consumers, respectively). This was an observational study, so could not establish cause, nor could the researchers rule out the possibility that other unknown (confounding) factors might have affected their results. https://www.bmj.com/content/378/bmj‐2022‐071204 Stricter blood sugar control in gestational diabetes leads to better outcomes for babies Lowering the target blood sugar level for mothers with gestational diabetes did not reduce the risk of large babies, a study published in PLOS Medicine found, but it did reduce the risk of death or injury to the baby during birth. Researchers from the University of Auckland and the Garvan Institute of Medical Research conducted a study of 1100 pregnant women with gestational diabetes seen at ten hospitals in New Zealand. During the study, each hospital switched from higher to lower blood sugar targets, and outcomes for women and babies in each group were compared. While tighter blood sugar control did not lead to babies being larger than expected, it did reduce the risk of infant death, trauma and shoulder dystocia during birth by half. However, tighter control almost doubled the risk of serious health outcomes for the mother, such as a major post partum haemorrhage, among other complications. The new results can help doctors decide what blood sugar level individual patients should strive for while managing their gestational diabetes. The study is believed to be the largest randomised comparison of two blood sugar level targets reported to date in a diverse population. However, the researchers point out that there is still a need to confirm their findings through additional randomised trials and in different health care settings. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004087

Perspectives

Medical education

Editorials

Research

Infectious diseases 27 June 2022 Open Access

People in intensive care with COVID‐19: demographic and clinical features during the first, second, and third pandemic waves in Australia

Higher in-hospital mortality during the third wave may reflect the virulence of Delta or the higher number of ICU admissions

Husna Begum · Ary S Neto · Patricia Alliegro · Tessa Broadley · Tony Trapani · Lewis T Campbell · Allen C Cheng · Winston Cheung · D James Cooper · Simon J Erickson · Craig J French · Edward Litton · Richard McAllister · Alistair Nichol · Annamaria Palermo · Mark P Plummer · Hannah Rotherham · Mahesh Ramanan · Benjamin Reddi · Claire Reynolds · Steven AR Webb · Andrew A Udy · Aidan Burrell

Study protocol

Research letter

Guideline summary

Letters

Ethics 3 October 2022 Free

Skeletons in the closet: time to give human bones acquired by health practitioners for educational purposes the respect they deserve

To the Editor: The concepts presented by Coman and colleagues1 parallel international trends within anatomical societies, where attitudes on human remains used for educational purposes are under scrutiny.2 Illuminating issues around legacy collections, and pressing for further clarity, transparency and appropriate cultural and ethical solutions, is important for the proper treatment of these precious resources. It is also necessary given recent events that have raised concerns within the public about how human remains and anatomical collections are treated under the guise of education.3 We strongly support the points made by Coman et al around development of repatriation policies for privately held bones, but we respectfully suggest additional considerations. The suggestion “Medical ethicists assert that in the absence of consent, anatomical specimens … should be destroyed”1 is not congruent with current suggestions and practice.4 Anatomical collections that have no provenance or consent are often used as teaching resources and represent the tangible legacies of histories of this field of science. As such, they serve the additional educational purpose of eliciting discussions on contemporary ethical and professional practice.5 There are also benefits associated with using real bones as opposed to three‐dimensional or plastic copies that do not retain the same weight, detail or nuanced anatomical features. Arguments do exist for disposition of unconsented collections, but these should be considered against the educational value these remains deliver and the social, ethical and cultural concerns around their ongoing use. In proposing consultation across various groups to clarify appropriate practice around “managing the legacy of human bone use in education,“1 we suggest it is necessary to include other specific interest groups to ensure community‐appropriate practices are developed. It is essential that community input is acquired, with indigenous representatives contributing knowledge and perspective. In addition, input from organisations that contribute expertise specific to national and international standards and practice are necessary. This should include local organisations, the Australian Institute of Anatomical Sciences and the Australian and New Zealand Association of Clinical Anatomists, and globally, the International Federation of Associations of Anatomists ethics committee. Such broad input is necessary to ensure guidelines are fit for purpose in a global education community.

Jon Cornwall · Sabine Hildebrandt · Thomas Champney

Environmental health 3 October 2022 Free

Improved life expectancy for Indigenous and non‐Indigenous people in the Northern Territory, 1999–2018: overall and by underlying cause of death

To the Editor: Zhao and colleagues1 recently published an article highlighting the improved life expectancy for Aboriginal and Torres Strait Islander men in the Northern Territory over the past 20years.1 This is both important and welcomed. It reflects consistent and concerted work of countless individuals and organisations that are contributing to the improved health and wellbeing of Aboriginal and Torres Strait Islander men in the NT, despite limited resources to do so. It makes sense that we are beginning, albeit slowly, to see these inroads. One example of contributing to the positive outcomes for Aboriginal and Torres Strait Islander men’s health in the NT is the evolution of the Darwin Men’s Inter‐Agency Network (DMIAN). DMIAN is a network of men from across government and the non‐government organisation sector to collaboratively advocate for Aboriginal and Torres Strait Islander men in Darwin.2 DMIAN has enabled men’s health researchers to better understand and act on the wants and needs of the Aboriginal and Torres Strait Islander men in the community from the perspective that matters most: their own. As Zhao and colleagues1 point out, there is still a long way to go with improving the life expectancy of Aboriginal and Torres Strait Islander men, which sits 15.4years behind non‐Indigenous men. In addition, as the life expectancy of Aboriginal and Torres Strait Islander men increases, so too does that of non‐Indigenous men.1 So if we are to close the gap, we cannot afford to lose momentum on targeted action, particularly that relating to Aboriginal and Torres Strait Islander male health and wellbeing.3,4 There is still a need for this to be a recognised priority in the NT and nationally, and for primary health care and social services in the NT to be resourced appropriately. In particular, the Aboriginal Community Controlled Health Services and Aboriginal medical services have a key role to play and should be funded to develop, implement and evaluate health and social and emotional wellbeing programs for male clients, as this is severely lacking and is ultimately hampering progress in Aboriginal and Torres Strait Islander male health and wellbeing outcomes.4 While the National Men’s Health Strategy identifies Aboriginal and Torres Strait Islander men as a priority population,5 we also need substantially more investment in research and evaluation to find new innovate solutions.6 We hope the important work being done by individuals in health, justice, education and other social services sectors continues to be enabled to support Aboriginal and Torres Strait Islander men for the benefit of their communities and future generations.

Kootsy Canuto · Karla J Canuto · Jason Bonson · James Smith

Next Issue Volume 217 Issue 8

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MJA 217 8 17 Oct cover
News 17 October 2022 Free

News briefs

Perspectives 19 September 2022 Open Access

Twenty‐one years at the Uniting Medically Supervised Injecting Centre, Sydney Australia: addressing the remaining questions

Carolyn A Day · Allison Salmon · Marianne Jauncey · Mark Bartlett · Amanda Roxburgh

Perspectives 12 September 2022 Open Access

Latest evidence casts further doubt on the effectiveness of headspace

Steve Kisely · Jeffrey CL Looi

Perspectives 3 October 2022 Open Access

Robotic surgery: getting the evidence right

Wei Shen Tan · Anthony Ta · John D Kelly

Previous Issue Volume 217 Issue 6

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MJA20217 6 1920 Sept20cover
News 19 September 2022 Free

News briefs

Perspectives 5 September 2022 Open Access

Assessing the value of precision medicine health technologies to detect and manage melanoma

Rashidul A Mahumud · Monika Janda · H Peter Soyer · Pablo Fernández‐Peñas · Victoria J Mar · Rachael L Morton

Perspectives 19 September 2022 Open Access

Roadmap to incorporating group A Streptococcus molecular point‐of‐care testing for remote Australia: a key activity to eliminate rheumatic heart disease

Dylan D Barth · Gelsa Cinanni · Jonathan R Carapetis · Rosemary Wyber · Louise Causer · Caroline Watts · Belinda Hengel · Susan Matthews · Anna P Ralph · Janessa Pickering · Jeffrey W Cannon · Lorraine Anderson · Vicki Wade · Rebecca J Guy · Asha C Bowen

Perspectives 29 August 2022 Open Access

Establishing the worth of deprescribing inappropriate medications: are we there yet?

Ian A Scott · Emily Reeve · Sarah N Hilmer

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