Bisphosphonates and osteonecrosis: analogy to phossy jaw

A Michael Donoghue
Med J Aust 2005; 183 (3): . || doi: 10.5694/j.1326-5377.2005.tb06970.x
Published online: 1 August 2005

To the Editor: Osteonecrosis of the jaw, recently reported in patients treated with bisphosphonates, may be analogous to the historic occupational disease “phossy jaw”.1,2

  • Corporate Office, Alcoa World Alumina Australia, PO Box 252, Applecross, WA 6953.

  • 1. Carter G, Goss AN, Doecke C. Bisphosphonates and avascular necrosis of the jaw: a possible association. Med J Aust 2005; 182: 413-415. <MJA full text>
  • 2. Purcell PM, Boyd IW. Bisphosphonates and osteonecrosis of the jaw. Med J Aust 2005; 182: 417-418. <MJA full text>
  • 3. Hope EW, Hanna W, Stallybrass CO. Industrial hygiene and medicine. London: Bailliere, Tindall and Cox, 1923.
  • 4. Legge T. Industrial maladies. London: Humphrey Milford, Oxford University Press, 1934.
  • 5. Hunter D. Occupational diseases. Lecture II. Phosphorus, mercury, silver, manganese, metal fume fever, nickel carbonyl, infections, anthrax, glanders, weils disease, ankylostomiasis, cysticercosis, deficiency diseases. Lond Hosp Gaz 1935; 39: 25-50.
  • 6. Hamilton A. Exploring the dangerous trades. Boston: Little Brown and Company, 1943.


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