To the Editor: Forder et al conveyed that trials without allocation concealment have the potential to mislead.1 However, it is not true in any meaningful sense that “Without exception, allocation concealment is achievable in all randomised clinical trials.
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Allocation concealment and blinding: when ignorance is bliss
Vance W Berger
Med J Aust 2005; 183 (3): 165-166.
Vance W Berger, Biostatistician
Forder PM, Gebski VJ, Keech AC. Allocation concealment and blinding: when ignorance is bliss. Med J Aust 2005; 182: 87-89.
Berger VW, Christophi CA. Randomization technique, allocation concealment, masking, and susceptibility of trials to selection bias. J Mod Appl of Stat Methods 2003 2: 80-86.
Berger VW, Ivanova A, Deloria-Knoll M. Minimizing predictability while retaining balance through the use of less restrictive randomization procedures. Stat Med 2003; 22: 3017-3028.
Berger VW. Quantifying the magnitude of baseline covariate imbalances resulting from selection bias in randomized clinical trials (with discussion). Biometr J 2005; 47: 119-139.
Berger VW. Selection bias and covariate imbalances in clinical trials. Chichester: John Wiley & Sons, 2005.
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