MJA
MJA

The effectiveness of maternal pertussis vaccination for protecting Aboriginal and Torres Strait Islander infants against infection, 2012–2017: a retrospective cohort study

Lisa McHugh, Heather A D’Antoine, Mohinder Sarna, Michael J Binks, Hannah C Moore, Ross M Andrews, Gavin F Pereira, Christopher C Blyth, Paul Van Buynder, Karin Lust and Annette K Regan
Med J Aust 2024; 220 (4): . || doi: 10.5694/mja2.52220
Published online: 4 March 2024

Abstract

Objectives: To evaluate the effectiveness of maternal pertussis vaccination for preventing pertussis infections in Aboriginal and Torres Strait Islander infants under seven months of age.

Study design: Retrospective cohort study; analysis of linked administrative health data.

Setting, participants: Mother–infant cohort (Links2HealthierBubs) including all pregnant women who gave birth to live infants (gestational age ≥ 20 weeks, birthweight ≥ 400 g) in the Northern Territory, Queensland, and Western Australia during 1 January 2012 – 31 December 2017.

Main outcome measures: Proportions of women vaccinated against pertussis during pregnancy, rates of pertussis infections among infants under seven months of age, and estimated effectiveness of maternal vaccination for protecting infants against pertussis infection, each by Indigenous status.

Results: Of the 19 892 Aboriginal and Torres Strait Islander women who gave birth to live infants during 2012–2017, 7398 (37.2%) received pertussis vaccine doses during their pregnancy, as had 137 034 of 259 526 non‐Indigenous women (52.8%; Indigenous v non‐Indigenous: adjusted odds ratio, 0.66; 95% confidence interval [CI], 0.62–0.70). The annual incidence of notified pertussis infections in non‐Indigenous infants declined from 16.8 (95% CI, 9.9–29) in 2012 to 1.4 (95% CI, 0.3–8.0) cases per 10 000 births in 2017; among Aboriginal and Torres Strait Islander infants, it declined from 47.6 (95% CI, 16.2–139) to 38.6 (95% CI, 10.6–140) cases per 10 000 births. The effectiveness of maternal vaccination for protecting non‐Indigenous infants under seven months of age against pertussis infection during 2014–17 was 68.2% (95% CI, 51.8–79.0%); protection of Aboriginal and Torres Strait Islander infants was not statistically significant (36.1%; 95% CI, –41.3% to 71.1%).

Conclusions: During 2015–17, maternal pertussis vaccination did not protect Aboriginal and Torres Strait Islander infants in the NT, Queensland, and WA against infection. Increasing the pertussis vaccination rate among pregnant Aboriginal and Torres Strait Islander women requires culturally appropriate, innovative strategies co‐designed in partnership with Indigenous organisations and communities.

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Equitable access to abortion care is still not a reality in Australia

Asvini K Subasinghe and Seema Deb
Med J Aust 2024; 220 (3): . || doi: 10.5694/mja2.52210
Published online: 19 February 2024

The 2023 Senate inquiry into universal access to reproductive health care identified major structural barriers to abortion care in Australia.1 However, in the absence of a national abortion registry, it is unclear whether access is equitable and what factors influence the provision of abortion care. In two articles published in this issue of the MJA, researchers report large population‐based studies that investigated these questions in Victoria.

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  • 1 Monash University, Melbourne, VIC
  • 2 Eastern Health, Box Hill Hospital, Melbourne, VIC



Competing interests:

No relevant disclosures.

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The participation of Aboriginal and Torres Strait Islander parents in Australian trials of parenting programs for improving children's health: a scoping review

Jake MacDonald, Myles Young, Briana Barclay, Stacey McMullen, James Knox and Philip Morgan
Med J Aust || doi: 10.5694/mja2.52198
Published online: 12 February 2024

Abstract

Objectives: To assess the inclusion of Aboriginal and Torres Strait Islander parents in trials of parenting programs in Australia; the involvement of Indigenous fathers in such studies; and whether parenting programs are designed to be culturally appropriate for Aboriginal and Torres Strait Islander people.

Study design: Scoping review of peer‐reviewed journal publications that report quantitative outcomes for Australian randomised control trials of parenting programs in which the participants were parents or caregivers of children under 18 years of age, and with at least one outcome related to children's health, health behaviour, or wellbeing.

Data sources: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Scopus databases.

Data synthesis: Of 109 eligible publications, nine reported how many participants were Aboriginal or Torres Strait Islander people; three specified whether they were Aboriginal, Torres Strait Islander, or both. Two publications described specific interventions for Aboriginal and Torres Strait Islander children; both reported consultation with Indigenous people regarding program design. Of the 15 559 participating parents in all included publications, 93 were identified as Aboriginal or Torres Strait Islander people. No publications noted as study limitations the absence of consultation with Indigenous people or the low participation rate of Aboriginal and Torres Strait Islander families.

Conclusions: The specific needs and interests of Aboriginal and Torres Strait Islander families have not generally been considered in Australian trials of parenting programs that aim to improve the mental and physical health of children. Further, Indigenous people are rarely involved in the planning and implementation of the interventions, few of which are designed to be culturally appropriate for Indigenous people. If parenting research in Australia is to support Aboriginal and Torres Strait Islander families, it must include consultation with local communities, adapt interventions and research methods to the needs of the participating parents and their communities, and improve the recruitment and retention of Aboriginal and Torres Strait Islander participants.

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  • 1 Office of Indigenous Strategy and Leadership, University of Newcastle, Newcastle, NSW
  • 2 The University of Newcastle, Newcastle, NSW
  • 3 Centre for Active Living and Learning, University of Newcastle, Newcastle, NSW



Open access:

Open access publishing facilitated by The University of Newcastle, as part of the Wiley ‐ The University of Newcastle agreement via the Council of Australian University Librarians.


Competing interests:

No relevant disclosures.

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Baby steps in lobbying reform: opportunities and challenges in Queensland

Jennifer Lacy‐Nichols and Katherine B Cullerton
Med J Aust 2024; 220 (2): . || doi: 10.5694/mja2.52187
Published online: 5 February 2024

Australia is lacklustre in its political transparency. This makes it challenging to see if commercial actors have undue influence over policy decisions, which is a risk for public health.

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  • 1 University of Melbourne, Melbourne, VIC
  • 2 University of Queensland, Brisbane, QLD



Acknowledgements: 

Jennifer Lacy‐Nichols is the recipient of a fellowship to research the commercial determinants of health from the Victorian Health Promotion Foundation (VicHealth). VicHealth had no role in the planning, writing or publication of the work.

Competing interests:

No relevant disclosures.

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Why clinical artificial intelligence is (almost) non‐existent in Australian hospitals and how to fix it

Anton van der Vegt, Victoria Campbell and Guido Zuccon
Med J Aust || doi: 10.5694/mja2.52195
Published online: 5 February 2024

In‐hospital clinical artificial intelligence (AI) encompasses learning algorithms that use real‐time electronic medical record (EMR) data to support clinicians in making treatment, prognostic or diagnostic decisions. In the United States, the implementation of hospital‐based clinical AI, such as sepsis or deterioration prediction, has accelerated over the past five years,1 while in Australia, outside of digital imaging‐based AI products, nearly all hospitals remain clinical AI‐free zones. Some would argue this is a good thing, both prudent and sensibly cautious given the wide ranging ethical, privacy and safety concerns;2,3 others contend our consumers are missing out on important interventions that save lives and improve care.4,5 In this perspective article, we argue that in‐hospital clinical AI excluding imaging‐based products (herein referred to as “clinical AI”) can improve care and we examine what is preventing clinical AI uptake in Australia and how to start to remedy it.

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  • 1 Centre for Health Services Research, University of Queensland, Brisbane, QLD
  • 2 Sunshine Coast University Hospital, Sunshine Coast, QLD
  • 3 University of Queensland, Brisbane, QLD


Correspondence: a.vandervegt@uq.edu.au


Open access:

Open access publishing facilitated by The University of Queensland, as part of the Wiley ‐ The University of Queensland agreement via the Council of Australian University Librarians.


Acknowledgements: 

Anton van der Vegt is supported by the Advance Queensland Industry Research Fellowship granted by the Queensland Government. The funder played no role in the writing or publication of this study.

Competing interests:

No relevant disclosures.

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Contemporary management of advanced colorectal cancer: the Australian experience

Kilian GM Brown, Nabila Ansari and Michael J Solomon
Med J Aust || doi: 10.5694/mja2.52218
Published online: 5 February 2024

Colorectal cancer (CRC) is the third most common cancer in Australia, with almost 16 000 new cases in 2022 accounting for 10% of new cancer diagnoses and 11% of cancer‐related deaths.1 There has been a well documented increase in the incidence of CRC in people under the age of 50 years in Australia in recent decades, while the incidence in those older than 50 years has decreased over the same period.2 Treatment of CRC has evolved dramatically in the 21st century, particularly for patients with advanced disease. Advances in medical imaging and peri‐operative medicine, as well as refinement of surgical techniques, have facilitated radical resection in selected patients with advanced or recurrent local disease, as well as those with limited metastases, who would otherwise be considered incurable. Improvements in systemic therapy mean that, in contemporary practice, many patients with metastatic (stage IV) CRC who historically had few systemic treatment options and a poor anticipated survival may now be afforded durable disease control and have a life expectancy measured in years rather than months. CRC is increasingly understood to be a biologically heterogenous disease. As the behaviour of individual tumours is better characterised by their molecular profiles, targeted systematic therapy combined with ablative techniques and radical surgery in selected patients can be expected to further improve outcomes. This article describes recent developments in the management of advanced CRC and how these advances are reflected in contemporary Australian practice.

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  • 1 Royal Prince Alfred Hospital, Sydney, NSW
  • 2 Surgical Outcomes Research Centre, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW



Open access:

Open access publishing facilitated by The University of Sydney, as part of the Wiley – The University of Sydney agreement via the Council of Australian University Librarians.


Competing interests:

No relevant disclosures.

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  • 15. Raoof M, Whelan RL, Sullivan KM, et al. Safety and efficacy of oxaliplatin pressurized intraperitoneal aerosolized chemotherapy (PIPAC) in colorectal and appendiceal cancer with peritoneal metastases: results of a multicenter phase I trial in the USA. Ann Surg Oncol 2023; 30: 7814‐7824.
  • 16. Cercek A, Lumish M, Sinopoli J, et al. PD‐1 blockade in mismatch repair‐deficient, locally advanced rectal cancer. N Engl J Med 2022; 386: 2363‐2376.
  • 17. Chalabi M, Verschoor YL, van den Berg J, et al. Neoadjuvant immune checkpoint inhibition in locally advanced MMR‐deficient colon cancer: the NICHE‐2 study [abstract]. Ann Oncol 2022; 33 (S7): S1389.
  • 18. Kopetz S, Grothey A, Yaeger R, et al. Encorafenib, binimetinib, and cetuximab in BRAF V600E‐mutated colorectal cancer. N Engl J Med 2019; 381: 1632‐1643.
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Sexual and reproductive health and rights in Australia: we have much to celebrate but must not be complacent

Catriona Melville and Bonney Corbin
Med J Aust || doi: 10.5694/mja2.52194
Published online: 29 January 2024

In a world where sexual and reproductive injustice continues, Australia has been quietly making changes for the better. Australian sexual and reproductive health law reforms have been prodigious in recent years: we have seen more changes in the past six years than in the previous 60. Alongside Australia's progression, however, sexual and reproductive rights have been considerably eroded in other countries. How does the global context of reproductive rights affect Australia? And how can we protect not only our hard‐fought liberties but also ensure they are equitable and clinically fit for purpose?

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  • MSI Australia, Melbourne, VIC



Competing interests:

No relevant disclosures.

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Socio‐economic status and access to fluoridated water in Queensland: an ecological data linkage study

Christopher T Sexton, Diep H Ha, Thu Le, Ratilal Lalloo, Pauline Ford, Loc G Do and Nicole Stormon
Med J Aust || doi: 10.5694/mja2.52196
Published online: 22 January 2024

Abstract

Objectives: To investigate the relationship between access to fluoridated drinking water and area‐level socio‐economic status in Queensland.

Study design: Ecological, geospatial data linkage study.

Setting: Queensland, by statistical area level 2 (SA2), 2021.

Main outcome measures: Proportion of SA2s and of residents with access to fluoridated drinking water (natural or supplemented); relationship at SA2 level between access to fluoridated water and socio‐economic status (Index of Relative Socio‐economic Advantage and Disadvantage, IRSAD; Index of Economic Resources, IER).

Results: In 2021, an estimated 4 050 168 people (79.4% of the population) and 397 SA2 regions (72.7%) in Queensland had access to fluoridated water. Access was concentrated in the southeastern corner of the state. After adjusting for SA2 population, log area, and population density, the likelihood of access to fluoridated drinking water almost doubled for each 100‐rank increase in IRSAD (adjusted odds ratio [aOR], 1.93; 95% confidence interval [CI], 1.59–2.36) or IER (aOR, 1.77; 95% CI, 1.50–2.11).

Conclusions: The 2012 decision to devolve responsibility for water fluoridation decisions and funding from the Queensland government to local councils means that residents in lower socio‐economic areas are less likely to have access to fluoridated water than those in more advantaged areas, exacerbating their already greater risk of dental disease. Queensland water fluoridation policy should be revised so that all residents can benefit from this evidence‐based public health intervention for reducing the prevalence of dental caries.

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  • 1 The University of Queensland, Brisbane, QLD
  • 2 Metro North Hospital and Health Service, Queensland Health, Brisbane, QLD


Correspondence: c.sexton@uq.edu.au

Acknowledgements: 

We acknowledge Queensland Health for providing access to the water fluoridation data for this article.

Competing interests:

No relevant disclosures.

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The Australian Government's new vaping policy should be part of a larger plan towards a tobacco endgame

Samantha Howe, Driss Ait Ouakrim, Tony Blakely and Coral E Gartner
Med J Aust || doi: 10.5694/mja2.52197
Published online: 22 January 2024

The Australian Minister for Health and Aged Care, Mark Butler, made a strong push to address the growing problem of youth vaping in his speech at the National Press Club in May 2023.1 While new approaches to controlling youth vaping are urgently needed, it is critical that policy reforms to end the tobacco cigarette epidemic are also pursued with equal vigour — otherwise we risk shifting people currently using vapes to tobacco smoking. In this article, we argue that Australia should leverage its strong vaping regulation to commit in parallel to an ambitious commercial tobacco endgame to rapidly minimise smoking.

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  • 1 Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC
  • 2 School of Public Health, University of Queensland, Brisbane, QLD


Correspondence: howe.s@unimelb.edu.au


Open access:

Open access publishing facilitated by The University of Melbourne, as part of the Wiley ‐ The University of Melbourne agreement via the Council of Australian University Librarians.


Competing interests:

Coral Gartner is currently funded by the National Health and Medical Research Council (GNT1198301) towards the Centre for Research Excellence on Achieving the Tobacco Endgame (2020–2025). She also receives funding from an Australian Research Council Fellowship (FT220100186) to develop new regulatory options to minimise the legal and illegal tobacco markets (2023–2026). Tony Blakely and Ait Ouakrim were contracted by the Aotearoa NZ Health Ministry (2021–2022) to undertake modelling of the Smokefree Aotearoa 2025 Action Plan.

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Providing Australian children and adolescents with equitable access to new and emerging therapies through clinical trials: a call to action

Michelle S Lorentzos, David Metz, Andrew S Moore, Laura K Fawcett, Paula Bray, Lani Attwood, Craig F Munns and Andrew Davidson
Med J Aust || doi: 10.5694/mja2.52191
Published online: 15 January 2024

Opportunities for children to benefit from novel therapies have increased substantially over the past decade. Change is needed to maximise these opportunities, particularly in the paediatric trial environment. Investment and a coordinated national approach are needed to prevent Australian children falling behind their international peers. There is international recognition that collaborative approaches and strategic investment in paediatric clinical trials reap benefits in terms of access to clinical trials and new therapies. This article exemplifies a multi‐state collaboration and presents a united call to action to prioritise paediatric clinical trials, by strategically investing in effective governance and infrastructure, and a shift in culture that embeds clinical trials in the core business of paediatric health care and academic institutions.

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  • 1 Kids Research, Sydney Children's Hospitals Network, Sydney, NSW
  • 2 University of Sydney, Sydney, NSW
  • 3 Monash Children's Clinical Trial Centre, Monash Children's Hospital, Melbourne, VIC
  • 4 Monash University, Melbourne, VIC
  • 5 Child Health Research Centre, University of Queensland, Brisbane, QLD
  • 6 Queensland Children's Hospital, Brisbane, QLD
  • 7 University of New South Wales, Sydney, NSW
  • 8 Sydney Children's Hospitals Network, Sydney, NSW
  • 9 Royal Children's Hospital, Melbourne, VIC
  • 10 Melbourne Children's Trials Centre, Murdoch Children's Research Institute, Melbourne, VIC



Open access:

Open access publishing facilitated by The University of Sydney, as part of the Wiley - The University of Sydney agreement via the Council of Australian University Librarians.
 


Competing interests:

The Murdoch Children's Research Institute and Sydney Children's Hospitals Network have received funding from Roche to aid in building capacity for gene therapy in Australia. All authors’ hospitals and/or institutions are active sites for pharmaceutical company‐sponsored clinical trials and receive enrolment‐based reimbursement on a trial‐by‐trial basis, but do not receive direct funding for clinical trials capacity or capability building unless stated above.

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