Issues
Volume 221 Issue 6
Editor's choice
Policy influential research: setting, informing and decoding our national health and social policy agenda and activities
The MJA aims to prioritise studies that will “advance knowledge or practice with respect to medical problems of significance for Australia”. This is particularly inclusive of studies that not only have the potential to affect clinical practice, but also to help set, inform and improve our national health and social policies. In this issue of the MJA, we showcase several studies that have and will continue to inform national policy, help us understand how evidence can be used to best effect in the health policy process, and remind us of how and what is being done about other important national policy priorities. Australia's journey in regulating vaping, a relatively recent yet significant public health threat, especially to younger people, has taken a positive turn this year. The Therapeutic Goods and Other Legislation Amendment (Vaping Reforms) Act 2024 took effect in July 2024 and significant more regulation to access, packaging, and formulations of vapes was introduced nationally (https://www.aph.gov.au/Parliamentary_Business/Bills_Legislation/bd/bd2324a/24bd061a). These changes are internationally recognised as bold attempts at curbing vaping among younger people and have been influenced by an enormous body of work and advocacy. It is work such as Jenkins and colleagues’ (https://doi.org/10.5694/mja2.52423) in this issue, which identified a synthetic nicotine analogue (6‐methylnicotine) in “non‐nicotine” vapes and accompanying inconsistent chemical reporting, that are the pillars of evidence required to inform our national legislative journey. As noted by Larcombe and Hunter (https://doi.org/10.5694/mja2.52422) in an accompanying editorial, loopholes in legislation will continue to be used by vape manufacturers and our regulatory bodies must keep up, or ideally get in front of their attempts at circumventing them using evidence like that presented by Jenkins and colleagues. This issue of the MJA also includes a compendium piece for readers of modelled economic evaluations by Chen and colleagues (https://doi.org/10.5694/mja2.52409). Economic evaluations are ubiquitous and critical to how Australia makes decisions about medicines, devices, and other health care services (https://www.sciencedirect.com/science/article/pii/S221210992030666X), yet not always clearly accessible to non‐health economist readers. Chen et al remind us that with more complex questions, interventions, heterogenous populations, and luckily more computational power, more sophisticated model‐based economic evaluations are required, unavoidable, and our understanding of them must evolve. Using two recent MJA studies as examples (https://doi.org/10.5694/mja2.51825, https://doi.org/10.5694/mja2.51860), Chen et al describe how model‐based evaluations compare to study‐based evaluation, major modelling choices with powerful visual representations of these models and advice on what to look out for when determining model robustness. In Engel and Mihalopoulos’ perspective (https://doi.org/10.5694/mja2.52414), we read about loneliness and its economic impact, an area of increasing national recognition and evolving health and social policies. Loneliness, affecting almost one‐third of adults over 60 years of age and two‐thirds of older adults living in residential care, needs cost‐effective national strategies. Although a bidirectional relationship between loneliness and chronic health problems is not surprising, the magnitude of its potential health effects (eg, 26% higher risk of death), and the increasingly obvious impact that it has on our health system ($2.7 billion annually) that Engel and Mihalopoulos cite is alarming. However, it is not all doom and gloom. Engel and Mihalopoulos suggest that research has identified some critical elements of successful loneliness intervention strategies, including holistic community‐based and ‐led health and social care, and several promising intervention types. Interestingly, one such proposed strategy to address loneliness is “social prescribing”, which Yadav and colleagues’ (https://doi.org/10.5694/mja2.52413) letter to the editor introduces as the “core business” of Aboriginal and Torres Strait Islander community‐controlled health organisations. Yadav et al's call to action that we should learn more from Indigenous models of social prescribing could not have come at a more pertinent time.
Maria Inacio
Perspective
The loneliness epidemic: a holistic view of its health and economic implications in older age
The loneliness epidemic affecting older people is a costly public health concern
Lidia Engel · Cathrine Mihalopoulos
Calling time on the use of modified‐release opioids for acute pain
New Australian guidelines strongly recommend against prescription of modified-release opioids for patients with acute pain
Pamela E Macintyre · Melissa A Jamcotchian · Jennifer A Stevens
Should medical eponyms continue to be used in everyday practice?
Medical nomenclature should ideally describe the pathophysiological processes or clinical criteria relevant to the entity being defined
Leya Nedumannil · Diana Lewis
Medical education
A case of visceral leishmaniasis masquerading as autoimmune hepatitis
A 72-year-old man with a history of well controlled type 2 diabetes was admitted to a tertiary metropolitan hospital for investigation of fevers, night sweats and unintentional weight loss of 18kg over six months
Vinny Ea · Brigitte Papa · Rimma Goldberg
Understanding modelled economic evaluations: a reader's guide for clinicians
The role of modelled versus study-based economic evaluations, and an introduction to common modelling approaches
Winnie Chen · Martin Howell · Alan Cass · Gillian Gorham · Kirsten Howard
Erratum
Erratum
Chaturvedi S, Ullah S, Hughes (Wagadagam) JT. Kidney transplantation access and outcomes for Aboriginal and Torres Strait Islander children and young adults, 1963–2020: an ANZDATA registry study. Med J Aust 2024; https://doi.org/10.5694/mja2.52355 In the Results section of the Abstract, where it says “Five-and 10-year survival after kidney transplantation was similar for Aboriginal and Torres Strait Islander and non-Indigenous people”, it should read “Five-and 10-year patient survival after kidney transplantation was similar for Aboriginal and Torres Strait Islander and non-Indigenous people”. On page 48, the first sentence of the Methods section should start with “We used data prospectively …”. On page 48, in the Study outcomes section, where it says “Primary outcomes were time to first kidney transplantation, death, death-censored graft survival, and survival for people with end-stage kidney disease who did not receive kidney transplants (ie, remained on dialysis) during 1963–2020”, it should read “Primary outcomes were time to first kidney transplantation, death, death-censored graft survival, and survival for children and young adults with end-stage kidney disease who did not receive kidney transplants (ie, remained on dialysis) during 1963–2020”. On page 48, in the second paragraph of the Variables section, where it says “… cyclosporine/mycophenolate/ prednisone; 005–2020”, it should read “… cyclosporine/mycophenolate/ prednisone; 2005–2020”. On page 48, in the third paragraph of the Variables section, where it says “The status at modality treatment transition is defined as receiving a transplant, death, on dialysis, own kidney function recovered, or date of most recent visit if lost to follow-up”, it should read “The status at transition is defined as received transplant, patient death, on dialysis, own kidney function recovered, or date of most recent visit if lost to follow-up”.
Editorial
Hidden in plain sight: how vaping manufacturers exploit legislative loopholes
No unbiased toxicity data for 6-methylnicotine derived from realistic biological model or in human studies are available
Alexander Larcombe · Laura Hunter
Research
Non‐index hospital re‐admissions after hospitalisation with acute myocardial infarction and geographic remoteness, New South Wales, 2005–2020: a retrospective cohort study
Non-index hospital re-admission is associated with reduced mortality for people from regional or remote areas
Md Shajedur Rahman Shawon · Jennifer Yu · Art Sedrakyan · Sze‐Yuan Ooi · Louisa Jorm
Hospital costs for unplanned re‐admissions within 30 days of hospitalisations with heart failure, Australia, 2013–2017: a retrospective cohort study
Reducing the number of unplanned re-admissions could improve outcomes for people with heart failure and reduce hospital costs
Trang Dang · Wandy Chan · Sunnya Khawaja · James Fryar · Brenda Gannon · Sanjeewa Kularatna · William Parsonage · Isuru Ranasinghe
The health and economic burden of breathlessness, Australia, 2019: a national survey
Breathlessness imposes major burdens on individuals, the health care system, and the economy
Anthony P Sunjaya · Leanne M Poulos · Gian Luca Di Tanna · Thomas Lung · Guy B Marks · Helen K Reddel · Christine R Jenkins
Research letter
6‐Methylnicotine: a new nicotine alternative identified in e‐cigarette liquids sold in Australia
Clinicians should be aware of the availability of these products in Australia, including without prescription
Caitlin Jenkins · Celine Kelso · Jody Morgan
Narrative review
Towards a best practice framework for eHealth with Aboriginal and Torres Strait Islander peoples — important characteristics of eHealth interventions: a narrative review
Foundational qualities of culturally safe and sustainable eHealth interventions for Aboriginal and Torres Strait Islander people
the eHRCATSIH Group
Letter to the editor
“Social prescribing” another stolen Indigenous concept?
Uday N Yadav · Rosemary Wyber · Fiona Cornforth (Wuthathi/Maluilgal) · Raymond W Lovett (Wongaibon/Ngiyampaa)
News
There is a longstanding tradition in the medical world of naming diseases and conditions after individuals who made valuable contributions to their discovery.
There is a longstanding tradition in the medical world of naming diseases and conditions after individuals who made valuable contributions to their discovery. But who gets to be an eponym, who gets forgotten and should they be used at all? In a perspective published in the Medical Journal of Australia, Dr Leya Nedumannil and Dr Diana Lewis of Northern Hospital, Melbourne question the continued use of the naming style. “While not with the purpose to discredit the diligence of nor imply that unethical intentions always drove those after whom eponyms are coined, we believe their ongoing use in medicine without reflective deliberation may be detrimental,” the authors wrote. The academics say that in some cases the broader teams who were involved in medical discoveries don’t get the same recognition as the person with the eponym. An example of this is seen with Crohn’s disease, which is named after Burril B Crohn despite two other authors co-writing the paper where the condition was first described — Leon Ginzberg and Gordon D Oppenheimer. “Medical progress is seldom a solo feat, and the use of eponyms may threaten important values of collaboration and collegiality in this realm,” Dr Nedumannil and Dr Lewis wrote. Women throughout history have also been excluded with only 4% of medical eponyms being credited to women. “Numerous women have historically had their scientific achievements forgotten or inaccurately credited to men, a notion of systemic bias so widespread that it has ironically acquired an evocative eponymous title itself [the Matilda Effect], named after suffragist Matilda Gage,” the authors wrote. When names are best left in the past Another unintended consequence of using medical eponyms occurs when an individual is found to have engaged in unethical research or even crimes against humanity, as in the case of research undertaken by Nazi collaborators. “An example is the replacement of Wegener granulomatosis with granulomatosis with polyangiitis, due to Friedrich Wegener’s associations with the Nazi Party,” the authors wrote. There is also a risk of medical eponyms continuing a culture of colonialism through favouring Eurocentric researchers over knowledge from other nations and cultures. Research shows that 97% of medical eponyms celebrate European and North American physicians, despite 40% of pharmacological agents used in current practice originating from non-western medicine. “The failure to acknowledge accomplishments of cultural medical practices that often pre-dated and potentially inspired those of conventional medicine is not uncommon, and some eponyms may reflect this,” the authors wrote. A diagnosis by any other name… Even from a merely logistical standpoint, eponyms can cause confusion due to multiple systems or conditions being named after the same person, and because eponyms are not descriptive of the condition, this can make it difficult to communicate with patients. Both Dr Nedumannil and Dr Lewis argue that moving away from the use of medical eponyms would help medical terms avoid ethical pitfalls, while creating opportunities for more easily understandable terminology. “This could not only help dissociate medical terminology from the contentious milieu in which several eponyms came to existence, but potentially also facilitate more precise communication between clinicians and with patients,” they concluded. Read the perspective in the Medical Journal of Australia. The Medical Journal of Australia is a publication of the Australian Medical Association. The statements or opinions that are expressed in the MJA reflect the views of the authors and do not represent the official policy of the AMA or the MJA unless that is so stated. Media contacts: For all MJA enquiries, please contact news and online editor, Sally Block, at mja-media@mja.com.au
Sally Block
Theme issue on women's health: taking a holistic view
Francis Geronimo
Pregnancy, childbirth and the postpartum period: opportunities to improve lifetime outcomes for women with non‐communicable diseases
Jenny A Ramson · Myfanwy J Williams · Bosede B Afolabi · Stephen Colagiuri · Kenneth W Finlayson · Bianca Hemmingsen · Kartik K Venkatesh · Doris Chou
Leave no‐one behind: reducing health disparities for women experiencing homelessness in Australia
Lisa J Wood · Rhiannon C Villiers
Pharmaceuticals in pregnancy: a multifaceted challenge in Australia
Stefan C Kane · Renuka Shanmugalingam · Amanda Henry
Building and acting on the evidence for primary prevention of cancer
Elizabeth Zuccala
Overcoming disparities in hepatocellular carcinoma outcomes in First Nations Australians: a strategic plan for action
Jessica Howell · Troy Combo · Paula Binks · Kylie Bragg · Sarah Bukulatjpi · Kirsty Campbell · Paul J Clark · Melissa Carroll · Jane Davies · Teresa de Santis · Kate R Muller · Bella Nguyen · John K Olynyk · Nicholas Shackel · Patricia C Valery · Alan J Wigg · Jacob George · Stuart K Roberts
Priorities for planetary health equity in Australia
Sharon Friel · Katherine Trebeck · Nicholas Frank · Sandro Demaio · Megan Arthur · Chelsea Hunnisett · Francis Nona
Using conversant artificial intelligence to improve diagnostic reasoning: ready for prime time?
Ian A Scott · Tim Miller · Carmel Crock