MJA 216 9 16 May cover

Issues

Volume 216 Issue 9

16 May 2022

News

16 May 2022 Media release Free

Update to living guidelines for stroke care

NEW and updated recommendations for stroke management have been published as part of Australia’s living guidelines for stroke, a summary of which has been published today by the Medical Journal of Australia. In 2018, the Stroke Foundation and Cochrane Australia were awarded funding by the Australian Government (Medical Research Future Fund) to test a model of living guidelines for stroke management. These were the first Australian living clinical guidelines and are the first and only living stroke guidelines worldwide. The latest updated guidelines are available in full at the Stroke Foundation: https://informme.org.au/guidelines/clinical-guidelines-for-stroke-management Over 30 new and updated recommendations have been made since 2018. This includes five new strong recommendations: For patients with potentially disabling ischaemic stroke who meet perfusion mismatch criteria in addition to standard clinical criteria,he recommended time window for safe administration of alteplase has been extended to 9 hours post-stroke; For patients with potentially disabling ischaemic stroke due to large vessel occlusion who meet specific eligibility criteria intravenous tenecteplase (0.25 mg/kg, maximum 25 mg) or alteplase (0.9 mg/kg, maximum of 90 mg) should be administered up to 4.5 hours after the time the patient was last known to be well; For patients with ischaemic stroke caused by a large vessel occlusion in the internal carotid artery, proximal middle cerebral artery (M1 segment), or with tandem occlusion of both the cervical carotid and intracranial large arteries, endovascular thrombectomy should be undertaken when the procedure can be commenced between 6 and 24 hours after they were last known to be well if clinical and computed tomography perfusion or magnetic resonance imaging features indicate the presence of salvageable brain tissue; In hospitals without onsite 24/7 stroke medical specialist availability, telestroke systems should be used to assist in patient assessment and decision making regarding acute thrombolytic therapy and possible transfer for endovascular therapy. In patients with ischaemic stroke, cholesterol lowering therapy should target low density lipoprotein cholesterol < 1.8 mmol/L for secondary prevention of atherosclerotic cardiovascular disease. There are also three updates graded as strong recommendations: Aspirin plus clopidogrel should be commenced within 24 hours and used in the short term (first 3 weeks) in patients with minor ischaemic stroke or high risk transient ischaemic attack to prevent stroke recurrence; In patients with ischaemic stroke aged under 60 years in whom a patent foramen ovale is considered the likely cause of stroke after thorough exclusion of other aetiologies, percutaneous closure of the patent foramen ovale is recommended; For stroke survivors with reduced strength in their arms or legs, progressive resistance training should be provided to improve strength. “Rapid guideline updates as part of a living model are almost certain to have played a significant role by expediting local and state-wide system changes,” wrote the authors of the summary, led by Professor Coralie English, from the University of Newcastle. "Importantly, living guidelines provide currency of advice. The experience with stroke as well as other guidelines demonstrates that the rigour of the methods does not need to be compromised when living modes are adopted. “Our model of continual evidence surveillance and timely updates to recommendations is feasible, but sustainability remains a challenge. Now that we have started down this road, the message from guideline end users is that a return to the old model of static updates is no longer acceptable, and ongoing long term investment in living guidelines must be prioritised,” English and colleagues concluded.

Cate Swannell

16 May 2022 Free

News briefs

Delta’s trick to evade the body's immune response The SARS‐CoV‐2 Delta variant may use a novel invasion method to evade the body’s immune response, causing more damage to the brain, intestine and kidneys than the original Wuhan strain, according to a Griffith University study published in mBio. Led by Menzies Health Institute Queensland’s Dr Xiang Liu, the researchers compared the original Wuhan strain with Delta in mice models and found distinct immune response patterns between the ancestral and Delta variant. “In our study, we found that Delta‐infection induced the similar levels of disease symptoms as the ancestral SARS‐CoV‐2 but with significant dissemination and tissue damage to multiple organs including tissue lesions in the brain and intestinal wall thinning,” Dr Liu said. “Surprisingly, the numbers of leukocytes recruited to the lung tissue during Delta infection were significantly lower. These observations suggest the Delta variant may have yet unknown immune evasion mechanisms which increases infection. We hope to discover how this biological process happens with future research.” Dr Adam Taylor, who co‐led the study, said as SARS‐CoV‐2 variants were continually emerging it was critical to study disease progress to understand and manage clinical threats. “These results will help shed light on the changing disease profile of COVID‐19 and may guide therapeutic interventions for emerging SARS‐CoV‐2 variants,” he said. The Delta variant first emerged from India in 2020 and was found to be highly contagious compared to the Wuhan strain. Pfizer and AstraZeneca COVID‐19 vaccines were shown to have reduced effectiveness against Delta. Link found between arthritis, liver disease and haemochromatosis Research from Edith Cowan University, published in Mayo Clinic Proceedings, has identified a crucial link between arthritis and the risk of serious liver disease in people with Australia’s most common genetic condition, haemochromatosis. An estimated 100000 Australians carry the high risk genotype for haemochromatosis, a condition affecting people of northern European descent which sees the body accumulate too much iron. It can lead to advanced hepatic fibrosis, which can cause cirrhosis and liver cancer. Early detection of advanced hepatic fibrosis can assist clinicians in identifying those most at risk and reducing the impact or occurrence of future complications. The study analysed data from 112 people with haemochromatosis. Of the 19 subjects with advanced stage 3–4 liver fibrosis, 84% also had arthritis. However, of the 65 subjects without arthritis, only 5% had advanced hepatic fibrosis. “Since hepatic fibrosis improves with treatment, it is important to accurately determine the presence or absence of advanced hepatic fibrosis when patients are evaluated,” said senior author Professor John Olynyk. “We recommend people with haemochromatosis who present with arthritis be properly evaluated for the presence of advanced hepatic fibrosis.” Professor Olynyk said the link with arthritis could help diagnose more people with haemochromatosis, which can often be difficult due to many symptoms being relatively non‐specific and common in the general population. “People of the correct background presenting with arthritis or liver disease should always be evaluated for potential haemochromatosis,” he said. https://www.mayoclinicproceedings.org/article/S0025‐6196(22)00121‐5/fulltext

Perspectives

Medical education

Ethics and law

Editorials

Research

Research letter

Consensus statement summary

Letters

Cardiovascular diseases 16 May 2022 Free

Uncontrolled blood pressure in Australia: a call to action

To the Editor: We congratulate Schutte and colleagues1 for their call to action for improved management of blood pressure in Australia, highlighting that 68% of people have uncontrolled high blood pressure. The burden of high blood pressure is unevenly distributed, with Aboriginal and Torres Strait Islander (hereafter referred to respectfully as Indigenous) people reportedly having a higher rate of high blood pressure than non‐Indigenous Australians in every age group.2 Reducing the prevalence of high blood pressure is one of the most important means of reducing serious circulatory diseases, which are among the leading causes of death for Indigenous Australians.3 Hence, we want to extend the call to action and report on what is happening in primary health care settings with the control of blood pressure for Indigenous people. During 2012–13, we analysed blood pressure screening and follow‐up for patients diagnosed with hypertension (n = 6523) from 123 primary health care centres across Australia using continuous quality improvement data from audits of adherence to best practice chronic illness care.4 Given there are no recently available data on follow‐up actions after an abnormal blood pressure reading at this geographic scale, and as blood pressure continues to be relatively uncontrolled, these data continue to provide unique insight. The data, aggregated at primary health care centre level (Box), tells a story of clinical inertia. Regular blood pressure screening was done well — centres on average completed blood pressure screening for about 90% of patients within the past 6 and 12 months. In this cohort, about 65% of patients recorded abnormal blood pressure (n = 4240). Most primary health care centres had documentation of a follow‐up plan for more than 70% of patients, but there was wide variation (range, 0–100%; Box). Dealing with the low levels of medication reviews and adjustments (mean, ~15%; range, 0–100%) is a vital early step in limiting the contribution of uncontrolled blood pressure to adverse health outcomes for Indigenous people. These data support the need for training on strategies to overcome clinical inertia, which was identified as a top priority by over 200 Indigenous primary health care practitioners, managers and policymakers.5 We add to the call for more attention on prevention of cardiovascular disease and suggest additional investment in evidence‐based interventions appropriate to Indigenous Australian culture and needs. The time for system‐wide action has come. Box – Boxplots showing a record of scheduled services received by patients with hypertension and follow‐up of abnormal findings within the last 12 months of audit (unless otherwise indicated) at primary health centres during 2012–13 x = mean value. More information on how to interpret box plots is available in Matthews et al.4

Jodie Bailie · Veronica Matthews · Ross S Bailie

Infectious diseases 16 May 2022 Free

Clinical care of children and adolescents with COVID‐19: recommendations from the National COVID‐19 Clinical Evidence Taskforce

To the Editor: Fraile Navarro and colleagues1 recently published 20 recommendations for the treatment of coronavirus disease 2019 (COVID‐19) in children and adolescents from the National COVID‐19 Clinical Evidence Taskforce. For the paediatric inflammatory multisystem syndrome (PIMS‐TS) recommendations, the Taskforce convened an expert advisory group.1 In the absence of clinical trials, the panel considered peer‐reviewed guidelines and cohort studies to formulate consensus recommendations.1 However, they deferred providing any guidance to help clinicians prevent thromboembolism. We suggest the Taskforce consider the same approach for paediatric anticoagulation guidance. COVID‐19 is associated with marked coagulation activation and hypercoagulability in children.2,3 Life‐threatening pulmonary embolus requiring thrombolysis has been encountered in Australian adolescents hospitalised with COVID‐19. A retrospective cohort study published in 2021 found that 2.1% of children hospitalised with symptomatic COVID‐19 infection and 6.5% of those with PIMS‐TS developed thrombosis.4 Thrombosis occurred more frequently in children aged 12years and over who had central lines, PIMS‐TS, or an underlying oncological diagnosis. A D‐dimer of more than five times the upper limit of normal was significantly associated with thrombosis.4 The authors refer to “paediatric guidelines published in the US”, which are published on behalf of the Pediatric/Neonatal Hemostasis and Thrombosis Subcommittee of the International Society of Thrombosis and Haemostasis; these adapt current consensus prophylaxis guidelines to include COVID‐19‐specific features.5 In deferring making specific recommendations, the authors suggested using existing local thromboprophylaxis guidelines. The Royal Children’s Hospital, Melbourne and the Sydney Children’s Hospital, Randwick have both independently developed COVID‐19‐specific thromboprophylaxis guidelines (that are very closely aligned),6,7 as have many other centres globally because previous local thromboprophylaxis guidelines are inadequate for COVID‐19‐associated thrombotic coagulopathy. The Melbourne/Sydney guidelines advise baseline coagulation testing in hospitalised children with COVID‐19, incorporating D‐dimer to assist risk assessment, twice‐daily enoxaparin and anti‐Xa monitoring/dose titration.6,7 These could be provided as supplemental material in these living guidelines. The COVID‐19 anticoagulation in Children–Thromboprophylaxis (COVAC‐TP) trial — a phase 2 single‐arm study looking at 40 children who will receive monitored, low dose, twice‐daily enoxaparin (ClinicalTrials.gov Identifier NCT04354155) — will not change the level of evidence, so waiting for completion of this trial does not seem appropriate.

Gemma L Crighton · Anthea Greenway · Susan Russell

Dermatology 16 May 2022 Free

Mask exemptions for facial skin diseases: are they warranted?

To the editor: Clinicians are faced with requests for mask exemptions but guidance remains limited. In keeping with the Australasian College of Dermatologists’ guidelines,1 we believe skin problems are rarely severe enough to warrant exemption. The Department of Health and Human Services states people with “a serious skin condition of the face” are eligible for mask exemption,2 but this statement is open to interpretation. Mask exemptions for skin conditions are provided by numerous clinicians and not limited to dermatologists. Regardless of immunisation status, cases that may warrant exemption include severe dermatitis with crusting or weeping; severe infections such as impetigo or eczema herpeticum; bullous dermatoses, ectodermal dysplasias and other rare conditions featuring facial skin fragility; and post‐surgical procedures involving grafts or flaps where masks may impede healing. In addition, treatments for actinic damage such as 5‐fluorouracil, imiquimod or photodynamic therapy may cause severe inflammation.3 We suggest if exemptions are warranted, duration should be minimised, which may be before resolution of the dermatoses (eg, 2weeks followed by a review). This is essential given masks have been key in reducing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission.4 The development of an assessment pathway for facial dermatoses impeding mask use may be beneficial and should differentiate between health care workers, who wear fit‐tested masks, and the general public, guiding prompt treatment and follow‐up to facilitate a return to mask use. From our experience, facial masks may irritate the skin from pressure, sweating and humidity, and commonly aggravate underlying dermatoses, such as seborrheic dermatitis, acne or rosacea. Facial masks may rarely cause allergic contact dermatitis,5 and these cases should involve a contact dermatitis expert. Education regarding skin care is vital, in particular regular cleansing and reducing the number of products used which may aggravate acne. When utilising reusable masks, it is important to opt for an appropriate material such as light‐coloured cotton and maintain mask hygiene, which includes daily mask changes, regular washing, not sharing masks, and taking regular breaks from mask wearing. In summary, clinicians should remain vigilant when writing mask exemptions, aiming to minimise the duration by treating underlying skin problems and providing patient education.

Kajal Patel · Rosemary L Nixon

Next Issue Volume 216 Issue 10

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MJA 216 10 6 June cover
News 6 June 2022 Free

News briefs

Perspectives 6 June 2022 Free

Time to antithrombotic therapy after transient ischaemic attack and ischaemic stroke

Thanh G Phan · Benjamin Clissold · Henry Ma

Perspectives 6 June 2022 Free

The acute telestroke model of care in Australia: a potential roadmap for other emergency medical services?

Carlos Garcia‐Esperon · Christopher F Bladin · Timothy J Kleinig · Helen Brown · Jennifer J Majersik · Andrew Wesseldine · Kenneth Butcher

Perspectives 6 June 2022 Open Access

Functional neurological disorders: an Australian interdisciplinary perspective

Elizabeth Pepper · Adith Mohan · Kenneth Butcher · Mark Parsons · Jackie Curtis

Previous Issue Volume 216 Issue 8

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MJA 216 8 2 May cover
News 2 May 2022 Free

News briefs

Perspectives 18 April 2022 Open Access

Practical recommendations to communicate with patients about health‐related conspiracy theories

Mathew D Marques · Karen M Douglas · Daniel Jolley

Perspectives 2 May 2022 Open Access

Emerging evidence for the use of colchicine for secondary prevention of coronary heart disease

Stefan M Nidorf · Jamie Layland · Philip C Robinson · Sanjay Patel · Peter J Psaltis · Peter L Thompson

Perspectives 2 May 2022 Open Access

The need for improved Australian data on social determinants of health inequities

Joanne Flavel · Martin McKee · Toby Freeman · Connie Musolino · Helen Eyk · Fisaha H Tesfay · Fran Baum

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