Volume 178 - Issue 5
Is physiotherapy an effective treatment for lymphoedema secondary to cancer treatment?
Authors: Renea V Johnston, Jeremy N Anderson and Barbara L Walker
Med J Aust 2003; 178 (5): 236-237. || doi: 10.5694/j.1326-5377.2003.tb05170.x
Published online: 3 March 2003
Published online: 3 March 2003
Clinical question
A physiotherapist at Monash Medical Centre wanted to know the most effective physiotherapy treatments for lymphoedema following treatment for breast cancer.
Search question
People undergoing physiotherapy for lymphoedema formed the patient group of interest. Clinical outcomes were reduction or prevention of lymphoedema. A randomised controlled trial comparing physiotherapy treatment to no treatment, placebo, or other conservative treatment would be the most appropriate study design.
Search
The search term "lymph(o)edema" was combined with the general treatment search terms "physical therapy", "physiotherapy", "conservative treatment", "non-invasive treatment" and the more specific treatment terms "complex physical therapy", "compression sleeve/bandaging/garment", "manual lymphatic drainage", "mechanical compression" to identify all English-language controlled trials, meta-analyses and systematic reviews published between January 1970 and August 2000. We electronically searched the Cochrane Library, Best Evidence, MEDLINE, Cumulative Index of Nursing and Allied Health Library (CINAHL), Current Contents and the Physiotherapy Evidence Database (PEDro). We also searched the websites of 12 relevant health organisations, including the National Guidelines Clearinghouse, National Breast Cancer Centre, and Agency for Healthcare Research and Quality.
Summary of findings
Our search identified two systematic reviews,1,2 and five randomised controlled trials3-7 and one non-randomised controlled trial8 published subsequently to, or not included in, the systematic reviews.
There are few well-designed randomised controlled trials that examine the effectiveness of physical therapies for lymphoedema. The two identified systematic reviews1,2 included uncontrolled studies with methodological problems, and their conclusions cannot be confidently endorsed. Furthermore, as no single validated and widely acceptable outcome measure is available, comparison of results across trials or pooling of results in a meta-analysis is not appropriate.
Some conclusions can be drawn by examining the controlled studies included in the systematic reviews, and the subsequently published randomised3,4 and non-randomised8 controlled trials. While there is some evidence that compression garments reduce limb swelling, the addition of other modalities, including multilayer bandaging,4 manual lymphatic drainage,3,8 pneumatic pumps or electrical stimulation,1 does not provide additional benefit. However, one randomised controlled trial found that compression sleeves provided only short term benefit (over four weeks),6 while the remaining randomised controlled trials reported that compression was no more effective than manual lymphatic drainage7 or no active treatment5 to reduce lymphoedema.
The randomised controlled trials of Dini et al5 and Hornsby6 illustrate the importance of appropriate control groups. Both reported that adherence to skin-care guidelines and other self-care protocols reduces lymphoedema as effectively as the addition of active treatment.
Although the International Society of Lymphology9 recommends complex physical therapy (skin hygiene, lymph drainage, bandaging, and exercises in treatment and maintenance phases) as the initial treatment for lymphoedema, we found no rigorous evidence to support this.
Outcome
Subsequently published evidence-based clinical practice guidelines10 support our findings, namely that compression garments are of some but limited value, although they are as effective as other, more resource-intensive methods. Other physical therapies, such as complex physical therapy, pneumatic pumps, rigorous massage and compression bandaging, require further rigorous evaluation before recommendations about their use can be made. These recommendations were incorporated into a lymphoedema service for women in south-east Melbourne.
References
- Browning C. The management of lymphoedema. In: Redman S, Pillar C, Turner, J, Boyle F, editors. Lymphoedema: prevalence, risk factors and management: a review of research. Sydney: NHMRC National Breast Cancer Centre, 1997. i1082338
- Megens A, Harris SA. Physical therapist management of lymphedema following treatment for breast cancer: a critical review of its effectiveness. Phys Ther 1998; 78: 1302-1311. i1082340
- Andersen L, Hojris I, Erlandsen M, et al. Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage — a randomized study. Acta Oncologica 2000; 39: 399-405. i1082342
- Badger CM, Peacock JL, Mortimer PS. A randomized, controlled, parallel-group clinical trial comparing multilayer bandaging followed by hosiery versus hosiery alone in the treatment of patients with lymphedema of the limb. Cancer 2000; 88: 2832-2837. i1082344
- Dini D, Del Mastro L, Gozza A, et al. The role of pneumatic compression in the treatment of postmastectomy lymphedema. A randomized phase III study. Ann Oncol 1998; 9: 187-190. i1082346
- Hornsby R. The use of compression to treat lymphoedema. Prof Nurse 1995; 11: 127-128. i1082348
- Johansson K, Lie E, Ekdahl C, et al. A randomized study comparing manual lymph drainage with sequential pneumatic compression for treatment of postoperative arm lymphedema. Lymphology 1998; 31: 56-64. i1082350
- Johansson K, Albertsson M, Ingvar C, et al. Effects of compression bandaging with or without manual lymph drainage treatment in patients with postoperative arm lymphedema. Lymphology 1999; 32: 103-110. i1082352
- Bernas MJ, Whitte CL, Whitte MH. The diagnosis and treatment of peripheral lymphedema: draft revision of the 1995 Consensus Document of the International Society of Lymphology Executive Committee for discussion at the September 3-7, 2001, XVIII International Congress of Lymphology in Genoa, Italy. Lymphology 2001; 34: 84-91. i1082354
- Harris SR, Hugi MR, Olivotto IA, Levine M. Clinical practice guidelines for the care and treatment of breast cancer: 11. Lymphedema. CMAJ 2001; 164: 191-199. i1082356