Self-Poisoning With Prazosin and Its Off-Label Use in Australia, 2014–2024: Analysis of NSW Poisons Information Centre Data

NSW Poisons Information Centre data identified 1030 deliberate prazosin self-poisonings over 11 years, rising from 13 to 170 per year (2014–2024). Young women predominated, likely due to expanded off-label (but accepted) psychiatric use of prazosin. Better evidence on benefits of off-label use is needed to justify increasing risks.