Research letter
Open access CC BY NC ND
Volume 224 - Issue 7
Self-Poisoning With Prazosin and Its Off-Label Use in Australia, 2014–2024: Analysis of NSW Poisons Information Centre Data
Authors: Olivia B. E. Lal, Nicholas A. Buckley, Rose Cairns
Correspondence: olivia.lal@health.nsw.gov.au
Med J Aust 2026 || doi: 10.5694/mja2.70242
Published online: 1 July 2026
Published online: 1 July 2026
Abstract
NSW Poisons Information Centre data identified 1030 deliberate prazosin self-poisonings over 11 years, rising from 13 to 170 per year (2014–2024). Young women predominated, likely due to expanded off-label (but accepted) psychiatric use of prazosin. Better evidence on benefits of off-label use is needed to justify increasing risks.
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