Issues
Volume 211 Issue 7
News
News briefs
Vaccine for treating and preventing streptococcal toxic shock A vaccine developed by researchers at the Griffith University Institute for Glycomics could be used to treat and prevent toxic shock caused by invasive streptococcal disease, which kills more than 160 000 people every year. Group A Streptococci bacteria cause common, non‐life‐threatening illnesses such as impetigo (school sores) and tonsillitis, which are easily spread by coughing, sneezing, and sharing food and drinks. In about one in 100 cases, however, the organism enters the body, causing invasive streptococcal disease; which is potentially life‐threatening; mortality can exceed 25% in even the best equipped medical facilities. When invasive streptococcal disease occurs, some bacterial strains produce more toxins than others, causing streptococcal toxic shock syndrome (STSS). The international research team, which includes scientists from Melbourne and Edmonton, Canada, used a transgenic mouse model to develop the first candidate STSS vaccine, a conserved M protein peptide (“J8”). Vaccination with J8 reduced the bacterial burden in the spleen and blood of infected animals by 3–6 orders of magnitude. Administering antibody to J8 also cleared the infection in treated transgenic mice and reduced the mitogenic and inflammatory activity of the M protein, effects enhanced by adding antibody to the streptococcal pyrogenic exotoxin. The next step will be to produce monoclonal antibodies suitable for trials in humans. The research was published in Science Advances. https://advances.sciencemag.org/content/5/9/eaax3013 Botulinum toxin type A PBS listing extended After an extensive campaign by the authors of an MJAPerspective and the Rehabilitation Medicine Society of Australia and New Zealand, the Pharmaceutical Benefits Schedule listing for botulinum toxin type A will be extended to include adults with lower limb focal spasticity following a stroke. Dr Anupam Datta Gupta, a rehabilitation specialist at Adelaide's Queen Elizabeth Hospital, and public health academic Dr David Wilson wrote last year: “Spasticity can be moderated safely and effectively in both upper and lower limbs with botulinum toxin and the input of a skilled multidisciplinary team … Individuals with spasticity are already disadvantaged by their condition; they should not be further disadvantaged by ignoring effective treatment options.” Prior to the extension, botulinum toxin was subsidised for stroke patients with upper limb spasticity – but not those with lower limb spasticity – and for selected patients with cerebral palsy. According to the announcement, more than 2800 patients per year are expected to benefit from this listing. The federal Minister for Health noted that, “without PBS subsidy, patients would pay more than $5400 per year for this treatment.” https://www.mja.com.au/journal/2018/208/9/botulinum-toxin-spasticity-case-change-pharmaceutical-benefits-scheme https://www.greghunt.com.au/27-million-for-new-medicines/
Perspectives
The evolving role of intensive care in health care and society
Despite the evolving needs of patients and changing societal expectations, Australasian intensive care continues to provide a world leading service to patients and the broader society
Stephen Warrillow · Raymond Raper
Equity for Indigenous Australians in intensive care
The similarity in mortality among Indigenous and non-Indigenous critically ill patients hides a complex story
Paul J Secombe · Alex Brown · Michael J Bailey · David Pilcher
Towards gender balance in the Australian intensive care medicine workforce
Achieving gender equity in intensive care medicine requires specific interventions to attract and retain female trainees and support their progress to leadership roles
Lucy J Modra · Sarah A Yong
Evolution not revolution: the future of the randomised controlled trial in intensive care research
Innovative design methodologies may improve the statistical efficiency and success of future randomised trials
Sandra Peake · Anthony Delaney · Craig J French
Difficulties in knowing which critical care trial data warrant change in practice
Why is some strong evidence ignored while some weak evidence is rapidly acted upon?
Benjamin Reddi · Mark Finnis · Sandra Peake
Medical education
A structured approach to acid‐base interpretation
Understanding how to identify acid-base disorders is essential, as their consequences can be life-threatening
KJ Farley · Elisa Licari
Reflection
What is an intensive care specialist?
We are not viewed or valued by our community through a lens of disease, machines and location
Neil R Orford
Editorials
Outcomes for frail very old patients in the ICU are remarkably good
… but how are we deciding which patients are selected for ICU referral and admission?
Alison M Mudge
The “uberisation” of mental health care: a welcome global phenomenon?
New health information technologies have the potential to transform the delivery of mental health care
Ian B Hickie
Research
Frailty in very old critically ill patients in Australia and New Zealand: a population‐based cohort study
Routine screening of older ICU patients for frailty could improve outcome prediction and inform health care planning
Jai N Darvall · Rinaldo Bellomo · Eldho Paul · Ashwin Subramaniam · John D Santamaria · Sean M Bagshaw · Sumeet Rai · Ruth E Hubbard · David Pilcher
Research letter
The financial cost of intensive care in Australia: a multicentre registry study
Increasing ICU size may have improved health care system efficiency
Peter Hicks · Sue Huckson · Emma Fenney · Isobel Leggett · David Pilcher · Edward Litton
Narrative review
Perioperative considerations in the management of obstructive sleep apnoea
The increasing age and obesity rates of the Australian population are contributing to the higher prevalence of patients with obstructive sleep apnoea presenting for surgery
Nicolette R Holt · Glenn Downey · Matthew T Naughton
Letters
Record number of influenza tests in 2019, not a “mutant flu crisis”
Over two decades of Dutch experience can inform deliberations about the nature of a regulatory framework in Australian jurisdictions
Vicky Sheppeard · Robin Gilmour · Sean Tobin
Flinders medical students pilot free clinic for homeless men
To the Editor: Student‐run clinics (SRCs) empower students to employ logistics, operational management and clinical skills to provide free or affordable health care to underserved populations. SRCs have the dual benefits of student learning and care for underserved patients and promote health equity, interprofessionalism and student leadership.1,2 These clinics are well established in North America but are nascent in Australia. Some sections of the Australian population still face challenges accessing health care, including Aboriginal and Torres Strait Islander people, refugees and rural and homeless populations;3 SRCs not only meet this need but also assist with the growing demand for clinical placements for medical and allied health students.4 In 2012, the first Australian SRC began providing medical, nursing, social work and physiotherapy services in Melbourne,3 and similar clinics have also sprouted in New South Wales and Queensland.2,5 In the same vein, medical students from Flinders University in Adelaide piloted the Flinders Student Run Clinic (FSRC), with the support of faculty and of the Vinnie's Men's Crisis Centre, which provides crisis accommodation, meals, showers and case management for up to 47 homeless and vulnerable men aged over 18 years. From December 2016 to January 2017, student volunteers staffed weekend shifts providing consultations to residents. Clinic days were well subscribed, with about a dozen clients attending each session. Students were surveyed before and after volunteering on aspects of clinical training, preparedness and motivation. Out of 24 medical student volunteers, eight responded to the pre‐survey and six to the post‐survey. Before volunteering, students believed their clinical knowledge and skills would improve and they would be able to manage problems and unexpected events. After volunteering, students were less confident in their abilities and felt less valuable to the clinic, but were more prepared to work with vulnerable individuals, face morally challenging issues and achieve their goals. Volunteering also clarified students’ motivations and values, demystifying primary care with underserved populations, and they were motivated to be involved in similar programs in the future. Feeling less prepared may stem from exposure to responsibilities as primary health care staff on the ground. Further studies can explore expectation‐matching for different parties and the financial impact of similar programs. Furthermore, the use of SRCs in Australia to both teach and serve the community should be encouraged.
Andrew IH Phua · Yvonne K Parry
An unusual case of minor burns
To the Editor: A 40‐year‐old man with no past medical history presented to the emergency department complaining of a painful red rash across his back, which he noticed when he undressed at home after work. On examination, the patient was systemically well with normal vital signs. He had a non‐blanching, band‐shaped erythematous rash across his upper back, with no associated vesicles, consistent with a first degree burn. The patient worked as a field environmental engineer and was required to wear high visibility shirts throughout his working day. It was noticed that the band‐shaped rash coincided with the upper high visibility band on his work shirt (Box). The patient also reported that the high visibility tape on his shirt often becomes extremely hot when he works out in the sun, and he occasionally has to change position so the shirt does not touch his skin in that area. The rash was managed as a first degree burn, with emollient aloe vera cream and simple analgesia. Retroreflective tape is used on work clothing to increase the wearer's visibility to others, especially in the dark. It usually consists of minute glass beads or prismatic elements encapsulated in a transparent film, which reflect light back towards its source. Safety warnings mention cases of increased heat build‐up around shoulders, neck and ears, but no cases have been published in the medical literature. Skin abrasions have also been described when aged tape cracked and frayed was brushed against the forehead.1 The manufacturers also warn about the tape risk to smoulder or melt when subjected to heat. To the authors' knowledge, this is the first reported case of skin burns occurring secondary to overheating of retroreflective tape. Even though not life‐threatening, it caused discomfort to the patient for a few days. Workplaces mandating clothes with retroreflective tape should ensure that garments with the tape in areas touching the skin are not worn in very hot and sunny conditions and consider using removable vests instead. Manufacturers should consider designing shirts that decrease direct contact between retroreflective tape and skin, potentially by increasing the number or thickness of cloth layers under it. Box – Band‐shaped erythematous rash across the patient's upper back coinciding with the upper retroreflective band on the work shirt
Ioana Vlad
Careers
No regrets in intensive career
Professor Jeffrey Lipman is a world leader in intensive care medicine, and he wouldn’t have it any other way
Cate Swannell
Supplement
Project Synergy: co-designing technology-enabled solutions for Australian mental health services reform
Med J Aust 2019; 211 (7 Suppl).
Device closure for patent foramen ovale in patients with cryptogenic stroke: a paradigm in evidence
Francis J Ha · Heath Adams · Sonny Palmer
Including ethnic and cultural diversity in dementia research
Lee‐Fay Low · Annica L Barcenilla‐Wong · Bianca Brijnath
Chilaiditi sign
Phillippa Gray
Concussion risk and suicide prevention: balancing the risks and benefits of youth sport
Amanda Clacy · Daniel F Hermens · Kathryn Broadhouse · Jim Lagopoulos
Public health and economic perspectives on acute rheumatic fever and rheumatic heart disease
Jeffrey Cannon · Dawn C Bessarab · Rosemary Wyber · Judith M Katzenellenbogen
Australia's National Medicines Policy is outdated and in need of review
Brendan Shaw · Orin Chisholm