Homocysteine and vitamin status in older people in Perth

Leon A Flicker, Samuel D Vasikaran, Jenny Thomas, John G Acres, Paul E Norman, Konrad Jamrozik, Nicola T Lautenschlager, Peter J Leedman and Osvaldo P Almeida
Med J Aust 2004; 180 (10): . || doi: 10.5694/j.1326-5377.2004.tb06061.x
Published online: 17 May 2004

Leon A Flicker,* Samuel D Vasikaran, Jenny Thomas, John G Acres,§ Paul E Norman, Konrad Jamrozik,** Nicola T Lautenschlager,†† Peter J Leedman,‡‡ Osvaldo P Almeida§§

  • 1 School of Medicine and Pharmacology
  • 2 School of Medicine and Pharmacology and School of Psychiatry and Clinical Neurosciences
  • 6 Royal Perth Hospital, Box X2213, Perth, WA 6000.
  • 7 Department of Core Clinical Pathology and Biochemistry, Royal Perth Hospital, Perth, WA.
  • 8 Imperial College London, London, UK.



This work was supported by grants from the National Health and Medical Research Council of Australia, and untied research grants from Pfizer CVL, Australian Rotary Health Research Fund and the Australasian Menopause Society. We are grateful to the men and women who participated in this study.

  • 1. Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999; 354: 407-413.
  • 2. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med 2002; 346: 476-483.
  • 3. Cape RDT, Shinton NK. Serum vitamin B12 concentration in the elderly. Geronontologia Clinica 1961; 3: 163-172.
  • 4. Jamrozik K, Norman PE, Spencer CA, et al. Screening for abdominal aortic aneurysm: lessons from a population-based study. Med J Aust 2000; 173: 345-350.
  • 5. Seal EC, Metz J, Flicker L, Melny J. A randomised, double blind, placebo controlled study of oral vitamin B12 supplementation in elderly patients with subnormal or borderline serum vitamin B12 concentrations. J Am Geriatr Soc 2002; 50: 146-151.
  • 6. Reynolds EH. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry 2002; 72: 567–571.


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