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VEXAS syndrome causing fever of unknown origin

Anna Grosse, Tania Salehi, Mandy Callary, Jane R Hecker and Pravin Hissaria
Med J Aust 2022; 217 (3): . || doi: 10.5694/mja2.51646
Published online: 1 August 2022

A 69‐year‐old man had three hospital admissions from April to July 2021 with persistent fever of unknown origin. The onset was within one week of robotic radical prostatectomy for localised prostate adenocarcinoma. Associated features included diaphoresis, pruritis, anorexia with 15 kg of weight loss, sinus tachycardia, an urticarial rash over the torso and limbs, and chondritis of the left ear. The past medical history included hypertension, dyslipidaemia, gastro‐oesophageal reflux disease, asthma and multiple superficial venous thromboses.

  • Anna Grosse1
  • Tania Salehi1
  • Mandy Callary1
  • Jane R Hecker1
  • Pravin Hissaria1,2

  • 1 Royal Adelaide Hospital, Adelaide, SA
  • 2 SA Pathology, Adelaide, SA


Correspondence: anna.grosse@sa.gov.au

Competing interests:

No relevant disclosures.

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