An update of consensus guidelines for warfarin reversal

Krishna G Badami
Med J Aust 2014; 200 (2): . || doi: 10.5694/mja13.10271
Published online: 3 February 2014

To the Editor: The recently updated warfarin reversal guideline recommends prothrombin complex concentrate (PCC) dosing based on international normalised ratios (INRs), rather than fixed dosing.1 While achieving a target INR may be made more likely, this may be inconsequential clinically.2

  • New Zealand Blood Service, Christchurch, New Zealand.

Competing interests:

No relevant disclosures.

  • 1. Tran HA, Chunilal SD, Harper PL, et al. An update of consensus guidelines for warfarin reversal. Med J Aust 2013; 198: 198-199. <MJA full text>
  • 2. Leissinger CA, Blatt PM, Hoots WK, Ewenstein B. Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature. Am J Hematol 2008; 83: 137-143.
  • 3. Sarode R, Rawal A, Lee R, et al. Poor correlation of supratherapeutic international normalised ratio and vitamin K-dependent procoagulant factor levels during warfarin therapy. Br J Haematol 2006; 132: 604-607.
  • 4. Gatt A, Riddell A, van Veen JJ, et al. Optimizing warfarin reversal – an ex vivo study. J Thromb Haemost 2009; 7: 1123-1127.
  • 5. Poller L. International normalised ratios (INR): the first 20 years. J Thromb Haemost 2004; 2: 849-860.
  • 6. Le-Kim L, Kerr D, Kelly A. Are patients on warfarin with high INR treated according to published guidelines? The Internet Journal of Hematology 2009; 5. doi: 10.5580/24f2. (accessed Mar 2013).


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