High-dose intravenous flucloxacillin may affect warfarin therapy

Philip Y-I Choi, Katherine L Phillips and Ian Rae
Med J Aust 2011; 194 (11): . || doi: 10.5694/j.1326-5377.2011.tb03122.x
Published online: 6 June 2011

To the Editor: Warfarin is an orally administered vitamin K antagonist and has many well described interactions with commonly prescribed medications.1 However, only a handful of case reports worldwide have shown that flucloxacillin, a widely used antibiotic, may affect warfarin therapy by reducing its anticoagulant effect — in one instance contributing to the development of ischaemic stroke.2,3 There are several reports describing potential mech-anisms of interaction for flucloxacillin with warfarin.4,5

  • Philip Y-I Choi1
  • Katherine L Phillips1
  • Ian Rae2

  • 1 St George Hospital, Sydney, NSW.
  • 2 Queen Street Clinic, Grafton, NSW.



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