Volume 223 Issue 10 Supplement · 17 November 2025
The CURE Asthma Initiative
CURE Asthma: a unique opportunity for Australia
We stand at the beginning of the next bioscience revolution in asthma
Anthony Flynn · Wendy Edmondson · Alan James · Caroline Lodge · Vanessa M McDonald · Christine R Jenkins · John Blakey · Gary P Anderson
The CURE Asthma roadmap
Cures for asthma will require a sustained, decade-long program of discovery science partnered with best clinical expertise
Gary P Anderson · Anthony Flynn · Phil G Bardin · John D Blakey · Shyamali C Dharmage · Paul Foster · Peter G Gibson · Adam Jaffe · Alan James · Christine R Jenkins · Sundram Sivamalai · Peter D Sly · Guy B Marks · Vanessa M McDonald · Judy Wetttenhall
Defining “cure” for the asthmas
Cure can be defined as the extended absence of disease activity without treatment and minimal likelihood of relapse
Dennis Thomas · Vanessa M McDonald · Peter G Gibson · Richard Y Kim
Who gets asthma, and why?
A combine-to-cure approach is essential, simultaneously preventing harmful exposures and directed at the underlying biological mechanisms
Denby J Evans · Peter D Sly · Paul Foster · Chantal Donovan
Evidence from Australian cohort studies about asthma trajectories and transitions across the life course: a narrative review
Using novel statistical and artificial intelligence techniques to interrogate combined cohort datasets will open the door to drug discovery
Caroline Lodge · Xin Dai · Ingrid A. Laing · Michael P Menden · Anthony Flynn · Gary P Anderson · Sarath Ranganathan · Shyamali C Dharmage
Finding cures for asthma: new paradigms for drug discovery and therapy
Elucidating the molecular architecture of disease and focusing on earlier, more malleable biological features will lead to cures
Aowen Zhuang · Dennis Thomas · Caroline Lodge · Jane E Bourke · John W Upham · Vanessa M McDonald · Peter AB Wark · Gary P Anderson
Technological advances in the search for a CURE for asthma
Combining new technologies with artificial intelligence will enable more accurate disease prediction, precision diagnoses, and personalised treatments
Sara Quon · Timothy M Johanson · Ridhima Wadhwa · Alen Faiz · Anthony Flynn · Gary P Anderson · Amanda J Cox · Nicholas P West · Michael P Menden · Rhys S Allan
Differentiated and simplified oral HIV pre‐exposure prophylaxis (PrEP) models hold the key to virtually eliminating HIV transmission in Australia by 2030
Tyson Arapali · Sarah Warzywoda · Anthony K J Smith · Curtis Chan · Timothy R Broady · Erin Sullivan · Catherine MacPhail · Mohamed A Hammoud · Alexander Dowell‐Day · Benjamin R Bavinton
Rethinking diabetes care for Indigenous Australians: the need for Indigenous‐codesigned and led diabetes models of care
Natalie Nanayakkara · Sharon Atkinson‐Briggs · Alicia J Jenkins · Neale D Cohen
West Nile virus Kunjin subtype in rural NSW
Emily Gibson · Megan Whitley · Peter Murray · Linda Hueston · Jane Bennett · Raguharan Kathiresu · David N Durrheim
Mild traumatic brain injury and concussion and persisting post‐concussion symptoms: new guidelines to support evidence‐based assessment and management in Australia and Aotearoa New Zealand
Karen M Barlow · Jennie L Ponsford · Alice Theodom · Gill Cowen · Gavin A Davis · Vicki Anderson · Franz E Babl · David Cole · Jennifer Cullen · Stuart R Dalziel · Melinda Fitzgerald · Howard Flavell · Caroline Yates · Rebecca Kimble · John H Olver · Rhonda Orr · Mark Ralfe · Michael Rose · Nick Rushworth · Julia Treleaven · Gary Browne · Nathan Delang · Sarah Harris · Gary Mitchell · Sean Tweedy
Splenic injury in severe cases of the zoonoses Q fever and rickettsial infection: diagnostic challenges
Ashleigh Drury · Philippa Harrison · Aiveen Bannan
Medicolegal consequences of doctors accepting bequests and gifts under a patient’s will
Nicole E Kroesche · Tina L Cockburn · Kelly Purser · Karen A Sullivan