Connect
MJA
MJA

Chorea as a paraneoplastic syndrome heralding the transformation of non‐Hodgkin lymphoma

Rebecca Nothrop, Will Lee, Denise Lee and Amanda K Gilligan
Med J Aust 2021; 214 (3): . || doi: 10.5694/mja2.50918
Published online: 15 February 2021

An 81‐year‐old woman presented with subacute chorea as a paraneoplastic neurological syndrome (PNS) heralding the relapse and transformation of splenic marginal zone lymphoma (SMZL) into diffuse large B cell lymphoma (DLBCL).


  • 1 Eastern Health Foundation, Melbourne, VIC
  • 2 Neurosciences Clinical Institute, Epworth Eastern Hospital, , Melbourne, VIC
  • 3 Austin Health, Melbourne, VIC
  • 4 Monash University, , Melbourne, VIC



Competing interests:

No relevant disclosures.

  • 1. Conconi A, Franceschetti S, Aprile von Hohenstaufen K, et al. Histologic transformation in marginal zone lymphomas. Ann Oncol 2015; 26: 2329–2335.
  • 2. Giometto B, Grisold W, Vitaliani R, et al. Paraneoplastic neurologic syndrome in the PNS Euronetwork database: a European study from 20 centers. Arch Neurol 2010; 67: 330–335.
  • 3. O’Toole O, Lennon VA, Ahlskog JE, et al. Autoimmune chorea in adults. Neurology 2013; 80: 1133–1144.
  • 4. Vernino S, Tuite P, Adler CH, et al. Paraneoplastic chorea associated with CRMP‐5 neuronal antibody and lung carcinoma. Ann Neurol 2002; 51: 625–630.
  • 5. Dalmau J, Geis C, Graus F. Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system. Physiol Rev 2017; 97: 839–887.
  • 6. Pellkofer H, Schubart AS, Höftberger R, et al. Modelling paraneoplastic CNS disease: T‐cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat. Brain 2004; 127: 1822–1830.

Author

remove_circle_outline Delete Author
add_circle_outline Add Author

Comment
Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.