Fulminant meningococcal sepsis due to non-groupable Neisseria meningitidis in a patient receiving eculizumab

Victoria Hall, Rekha Pai Mangalore, Simon He, Kerrie Stevens, Jason A Trubiano, Natasha E Holmes, Benjamin P Howden and Jason C Kwong
Med J Aust 2018; 208 (11): . || doi: 10.5694/mja17.01012
Published online: 18 June 2018

Clinical record

  • 1 Austin Health, Melbourne, VIC
  • 2 University of Melbourne, Melbourne, VIC



This study was funded through the State Government of Victoria Department of Health and Human Services, and the Australian Government Department of Health. Jason Trubiano, Benjamin Howden and Jason Kwong are supported by the National Health and Medical Research Council. Jason Kwong and Jason Trubiano are also supported by Australian Government Research Training Program Scholarships.

Competing interests:

No relevant disclosures.

  • 1. Bond KA, Stevens K, Bulach D, et al. Rising incidence of invasive meningococcal disease caused by Neisseria meningitidis serogroup W in Victoria. Med J Aust 2016; 204: 265-266. <MJA full text>
  • 2. Pace D, Pollard AJ. Meningococcal disease: clinical presentation and sequelae. Vaccine 2012; 30: B3-B9.
  • 3. Benamu E, Montoya JG. Infections associated with the use of eculizumab: recommendations for prevention and prophylaxis. Curr Opin Infect Dis 2016; 29: 319-329.
  • 4. Health Canada. SOLIRIS (eculizumab) — increased risk of hemolysis or low hemoglobin with serogroup B meningococcal vaccination. Ottawa: Government of Canada; 2016. (viewed June 2017).
  • 5. McNamara LA, Topaz N, Wang X, et al. High risk for invasive meningococcal disease among patients receiving eculizumab (Soliris) despite receipt of meningococcal vaccine. MMWR 2017; 66: 734-737.


remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.