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New initiatives in the treatment of breast cancer

Ian N Olver
Med J Aust 2016; 205 (10): . || doi: 10.5694/mja16.01055
Published online: 21 November 2016

Better targeted therapies will reduce the burden of treatment, while improving the outcomes

With the 5-year survival for women diagnosed with breast cancer at 90%, the thrust of new initiatives is to discover whether that outcome can be either improved or achieved with less or better targeted therapy. Breast cancer was one of the first tumours to be successfully treated with a targeted therapy: trastuzumab improved outcomes for women with HER2-positive breast cancer, initially when treating metastatic disease, and then in the adjuvant therapy setting.1


  • Sansom Institute, University of South Australia, Adelaide, SA


Correspondence: ian.olver@unisa.edu.au

Competing interests:

No relevant disclosures.

  • 1. Li Z, Kang Y. Emerging therapeutic targets in metastatic progression: a focus on breast cancer. Pharmacol Ther 2016; 161: 79-96.
  • 2. Ehab M, Elbaz M. Profile of palbociclib in the treatment of metastatic breast cancer. Breast Cancer (Dove Med Press) 2016; 8: 83-91.
  • 3. Chen HR, Sherr DH, Hu Z, DeLisi C. A network-based approach to drug repositioning identifies plausible candidates for breast and prostate cancer. BMC Med Genomics 2016; 9: 51.
  • 4. Khoo BL, Grenci G, Jing T, et al. Liquid biopsy and therapeutic response: circulating tumour cell cultures for evaluation of anticancer treatment. Sci Adv 2016; 2: e1600274.
  • 5. Cardoso F, van’t Veer LJ, Bogaerts J, et al. 70-gene signature as an aid to treatment decisions in early-stage breast cancer. N Engl J Med 2016; 375: 717-729.
  • 6. Njeh CF, Saunders MW, Langton CM. Accelerated partial breast irradiation (APBI): a review of available techniques. Radiat Oncol 2010; 5: 90.
  • 7. Herrara FG, Bourhis J, Coukos G. Radiotherapy combination opportunities leveraging immunity for the next oncology practice. CA Cancer J Clin 2016; doi: 10.3322/caac.21358 [Epub ahead of print].
  • 8. Maguire A, Brogi E. Sentinel lymph nodes for breast carcinoma: a paradigm shift. Arch Pathol Lab Med 2016; 140: 791-798.
  • 9. Spillane MJ. What is new in the surgical management and prevention of breast cancer? Med J Aust 2016; 204: 311-314. <MJA full text>
  • 10. Arnold M, Jiang L, Stefanick ML, et al. Duration of adulthood overweight, obesity, and cancer risk in the Women’s Health Initiative: a longitudinal study from the United States. PLoS Med 2016; 13: e1002081.
  • 11. Siziopikou KP, Anderson SJ, Cobleigh MA, et al. Preliminary results of centralized HER2 testing in ductal carcinoma in situ (DCIS): NSABP B-43. Breast Cancer Res Treat 2013; 142: 415-421.

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