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Varenicline and proximal myopathy

Shelley E Wood and P Gerry Fegan
Med J Aust 2009; 190 (11): . || doi: 10.5694/j.1326-5377.2009.tb02611.x
Published online: 1 June 2009

To the Editor: We report a case of proximal myopathy attributed to varenicline therapy to assist with smoking cessation.


  • Fremantle Hospital and Health Service, Fremantle, WA.



  • 1. Cahill K, Stead L, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev 2008; (3): CD006103.
  • 2. eMIMS. Prescribing information: Champix. Sydney: CMP Medica Australia, 2006 (updated 20 Jun 2008). Subscription only. http://www.emims.net/Drugs/poisoning-and-drug-dependence/drug-and-alcohol-dependency/champix (accessed Nov 2008).
  • 3. El-Dada MD, Quik M. Involvement of nitric oxide in nicotinic receptor-mediated myopathy. J Pharmacol Exp Ther 1997; 281: 1463-1470.
  • 4. Mendell JR, Silverman LM, Verrill HL, et al. Imipramine-serotonin induced myopathy. Neurology 1976; 26: 968-974.

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