Hepatic encephalopathy precipitated by sodium valproate therapy

H S Subhash, Robert J Heddle, David W Schultz, John Ring and Campbell H Thompson
Med J Aust 2008; 188 (9): . || doi: 10.5694/j.1326-5377.2008.tb01780.x
Published online: 5 May 2008

To the Editor: We report the case of a 71-year-old woman who presented with a 3-week history of lethargy, subacute confusion and drowsiness. She was known to have a seizure disorder for which she had been taking lamotrigine 100 mg and sodium valproate 500 mg twice a day for 2 years.

  • H S Subhash1
  • Robert J Heddle1,2
  • David W Schultz3
  • John Ring3
  • Campbell H Thompson3

  • 1 Division of Medicine, Flinders Medical Centre, Adelaide, SA.
  • 2 Flinders University, Adelaide, SA.
  • 3 Flinders Medical Centre and Flinders University, Adelaide, SA.



We thank Professor Peter Roberts-Thomson, Director of the Department of Immunology at Flinders Medical Centre, for his expert opinion and advice.


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