Tramadol and new-onset seizures

Angelo Labate, Mark R Newton, Graeme M Vernon and Samuel F Berkovic
Med J Aust 2005; 182 (1): . || doi: 10.5694/j.1326-5377.2005.tb06556.x
Published online: 3 January 2005

Angelo Labate,* Mark R Newton, Graeme M Vernon, Samuel F Berkovic§

  • 1 Brain Research Institute
  • 3 Epilepsy Research Centre
  • 4 Austin Health, Heidelberg West, VIC 3081.


  • 1. Kahn LH, Alderfer RJ, Graham DJ. Seizures reported with tramadol. JAMA 1997; 278: 1661.
  • 2. Gasse C, Derby L, Vasilakis-Scaramozza C, Jick H. Incidence of first-time idiopathic seizures in users of tramadol. Pharmacotherapy 2000; 20: 629-634.
  • 3. Gardner JS, Blough D, Drinkard CR, et al. Tramadol and seizures: a surveillance study in a managed care population. Pharmacotherapy 2000; 20: 1423-1431.
  • 4. Jick H, Derby LE, Vasilakis C, Fife D. The risk of seizures associated with tramadol. Pharmacotherapy 1998; 18: 607-611.
  • 5. King MA, Newton MR, Jackson GD, et al. Epileptology of the first-seizure presentation: a clinical, electroencephalographic, and magnetic resonance imaging study of 300 consecutive patients. Lancet 1998; 352: 1007-1011.
  • 6. Australian Government. Health Insurance Commission. Available at: (accessed Nov 2004).


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