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Age-related macular degeneration and its possible prevention

Ian J Constable
Med J Aust 2004; 181 (9): . || doi: 10.5694/j.1326-5377.2004.tb06401.x
Published online: 1 November 2004

Despite well publicised claims of the therapeutic value of dietary supplements and other new treatments, the evidence for their effectiveness is modest


  • Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Nedlands, WA.


Correspondence: 

  • 1. Mitchell P, Smith W, Attebo K, et al. Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology 1995; 102: 1450-1460.
  • 2. Klein R, Davis MD, Mogli YL, et al. The Wisconsin age-related maculopathy grading system. Ophthalmology 1991; 98: 1128-1134.
  • 3. Macular Photocoagulation Study Group. Laser photocoagulation for juxtafoveal choroidal neovascularization. Five-year results from randomized clinical trials. Arch Ophthalmol 1994; 112: 500-509.
  • 4. TAP Study Group. Verteporfin therapy for subfoveal choroidal neovascularization in age-related macular degeneration: three-year results of an open-label extension of two randomized clinical trials. TAP Report No. 5. Arch Ophthalmol 2002; 120: 1307-1314.
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  • 6. Klein R, Klein BE, Linton KL, et al. The Beaver Dam Eye Study: the relationship of age-related maculopathy to smoking. Am J Epidemiol 1993; 137: 190-200.
  • 7. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol 2001; 119: 1191-1199.
  • 8. Cho E, Hung S, Willeton W, et al. Prospective study of dietary fat and risk of age-related macular degeneration. Am J Clin Nutr 2001; 73: 209-218.
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  • 10. Snow K, Seddon J. Do age-related macular degeneration and cardiovascular disease share common antecedents? Ophthalmic Epidemiol 1999; 6: 125-143.
  • 11. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS Report No. 8. Arch Ophthalmol 2001; 119: 1417-1436.

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