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Allergy to hydroxycobalamin, with tolerance of cyanocobalamin

David Heyworth-Smith and Patrick G Hogan
Med J Aust 2002; 177 (3): . || doi: 10.5694/j.1326-5377.2002.tb04709.x
Published online: 5 August 2002

To the Editor: Cyanocobalamin and hydroxycobalamin are synthetically derived preparations of vitamin B12. Allergy to vitamin B12 injection is infrequent, but may be serious. We describe a patient with allergy to hydroxycobalamin, without cross-reaction to cyanocobalamin.

  • 1. Woodliff HJ. Allergic reaction to cyanocobalamin injection. Med J Aust 1986; 144: 223.
  • 2. De Blay F, Sager MF, Hirth C, et al. IgE mediated reaction to hydroxycobalamin injection in a patient with pernicious anaemia. Lancet 1992; 339: 1535-1536.
  • 3. Vidal C, Lorenzo A. 1998 Anaphylactoid reaction to hydroxycobalamin with tolerance of cyanocobalamin. Postgrad Med J 1998; 74: 702.
  • 4. Cobcroft R, Cobcroft S. Oral vitamin B12 for B12 deficiency [letter]. Med J Aust 1999; 170: 451.

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