Is bupropion (Zyban) causing deaths?

Simon C Chapman and Konrad Jamrozik
Med J Aust 2002; 176 (3): . || doi: 10.5694/j.1326-5377.2002.tb04323.x
Published online: 21 January 2002

To the Editor: From 1 February to 30 June 2001, 277 602 prescriptions for the smoking cessation drug bupropion hydrochloride (Zyban, GlaxoSmithKline) were processed. The Health Insurance Commission approved 343 737 prescriptions for bupropion between 1 February and 30 June.1 Comparing this figure with the 277 602 processed scripts, some 66 135 (19.2%) scripts went unfilled. One reason for this may have been extensive publicity given to reports of deaths and numerous adverse reactions following bupropion use.

  • Simon C Chapman
  • Konrad Jamrozik


Competing interests:

SC has received funding from SmithKlineBeecham (now GlaxoSmithKline) for the preparation of professional and public educational material on smoking in Australia.


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