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Non-motor Parkinson disease: new concepts and personalised management

Nataliya Titova and K Ray Chaudhuri
Med J Aust 2018; 208 (9): . || doi: 10.5694/mja17.00993
Published online: 21 May 2018

Summary

 

  • Most patients with Parkinson disease (PD) have non-motor symptoms (NMS), and on average these can range from four to 19 different symptoms.
  • NMS dominate the prodromal phase of PD and some may serve as clinical biomarkers of PD.
  • NMS can be dopaminergic, non-dopaminergic, of genetic origin or drug induced.
  • Clinical assessment of NMS should include the NMS Questionnaire (completed by patients) for screening, as recommended by the International Parkinson and Movement Disorders Society and other international societies.
  • The total number of NMS in a patient with PD constitutes the NMS burden, which can be graded using validated cut-off scores on the NMS Questionnaire and Scale and can be used as an outcome measure in clinical trials.
  • Despite NMS burden having a major effect on the quality of life of patients and carers, a large European study showed that NMS are often ignored in the clinic.
  • The syndromic nature of PD is underpinned by non-motor subtypes which are likely to be related to specific dysfunction of cholinergic, noradrenergic, serotonergic pathways in the brain, not just the dopaminergic pathways.
  • NMS can be treated by dopaminergic and non-dopaminergic strategies, but further robust studies supported by evidence from animal models are required.
  • The future of modern treatment of PD needs to be supported by the delivery of personalised medicine.

 


  • 1 Pirogov Russian National Research Medical University, Moscow, Russia
  • 2 Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK


Correspondence: nattitova@yandex.ru

Acknowledgements: 

We thank the National Institute of Health Research Biomedical Research Centre and the Institute of Psychiatry, Psychology and Neuroscience at Kings College London for supporting research cited in this article, and the MDS Non-Motor Parkinson’s Disease Study Group.

Competing interests:

No relevant disclosures.

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Psychotropic drug prescribing in residential aged care homes

Gerard J Byrne
Med J Aust 2018; 208 (9): . || doi: 10.5694/mja18.00037
Published online: 21 May 2018

Individualised psychosocial interventions are needed as alternatives to pharmacological sedation

Sedating psychotropic drugs, including antipsychotics and benzodiazepines, are commonly prescribed in residential aged care facilities (RACFs), despite extensive evidence of their limited efficacy for treating behavioural and psychological symptoms in older people and of their potential for eliciting serious adverse effects, including death.1 As a consequence, efforts are afoot in many countries to minimise the use of these medications in RACFs. In this issue of the MJA, Westbury and colleagues2 report findings from the RedUSe study of a multi-component intervention designed to reduce the prescribing of sedative medications in Australian RACFs. This uncontrolled investigation employed four complementary interventions in 150 nursing homes: psychotropic medication audits by a local champion nurse; RACF staff education sessions conducted by a pharmacist using benchmarked local data and incorporating training in non-pharmacological interventions; interdisciplinary prescribing reviews for each RACF resident; and academic detailing for prescribers. This intervention sequence was repeated twice, 3 months apart. Data for 12 157 RACF residents collected at baseline, 3 months and 6 months indicated that prescribing of antipsychotics and benzodiazepine had decreased significantly following the intervention: the prevalence of antipsychotic use dropped from 21.6% of residents at baseline to 18.9% at 6 months, and that of benzodiazepines from 22.2% to 17.6%. For 39% of RACF residents taking antipsychotics or benzodiazepines at baseline, medication was ceased or the dosage reduced at 6 months.


  • University of Queensland, Brisbane, QLD


Correspondence: gerard.byrne@uq.edu.au

Competing interests:

No relevant disclosures.

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  • 2. Westbury JL, Gee P, Ling T, et al. RedUSe: reducing antipsychotic and benzodiazepine prescribing in residential aged care facilities. Med J Aust 2018; 108: 398-403.
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  • 6. Scales K, Zimmerman S, Miller SJ. Evidence-based nonpharmacological practices to address behavioural and psychological symptoms of dementia. Gerontologist 2018; 58: S88-S102.

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Tremor: a simple four-step approach to clinical assessment

Andre Loiselle
Med J Aust 2018; 208 (9): . || doi: 10.5694/mja18.00115
Published online: 21 May 2018

Tremor is the most common movement disorder encountered in clinical practice.1-3 It is defined as an involuntary, rhythmic and oscillatory movement of a body part. Tremors tend to be relatively constant in frequency but variable in amplitude,1 which may happen due to exaggeration of the physiological tremor or due to a tremor disorder. If significant enough, it may lead to medical presentation.


  • John Hunter Hospital, Newcastle, NSW


Series Editors

Balakrishnan (Kichu) R Nair

Simon O'Connor


Competing interests:

No relevant disclosures.

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Identifying genes in Parkinson disease: state of the art

Elaine GY Chew, Jia Nee Foo and Eng-King Tan
Med J Aust 2018; 208 (9): . || doi: 10.5694/mja17.01254
Published online: 21 May 2018

Recent studies are expanding our understanding of the genetic basis of Parkinson disease

Parkinson disease (PD) is a common neurodegenerative disorder which manifests as bradykinesia, movement rigidity and tremors in affected individuals. Our understanding of the genetic basis of PD has been steadily increasing since the initial report of α-synuclein mutations two decades ago.1 Mutations implicated in familial PD fully account for monogenic inheritance and point to potential functional mechanisms underlying PD.2,3 However, most sporadic PD cannot be accounted for by known familial PD genes, with the late-onset nature of PD making further linkage studies challenging. Genome-wide association and whole exome sequencing studies have implicated a growing list of mutations and genes in PD, which are expected to provide new insights into potential pathways involved in PD pathogenicity.


  • 1 Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore
  • 2 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
  • 3 National Neuroscience Institute, Singapore
  • 4 Duke–NUS Medical School, Singapore



Acknowledgements: 

Eng-King Tan acknowledges funding from the National Medical Research Council Singapore under the Singapore Translational Research Investigator Award and the Translational and Clinical Research Flagship Programme (NMRC/TCR/013-NNI/2014); Duke–NUS Medical School; and the Singapore Millennium Foundation. Jia Nee Foo is a Singapore National Research Foundation Fellow (NRF-NRFF2016-03).

Competing interests:

No relevant disclosures.

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Clinical Oncology Society of Australia position statement on exercise in cancer care

Prue Cormie, Morgan Atkinson, Lucy Bucci, Anne Cust, Elizabeth Eakin, Sandra Hayes, Alexandra L McCarthy, Andrew Murnane, Sharni Patchell and Diana Adams
Med J Aust 2018; 209 (4): . || doi: 10.5694/mja18.00199
Published online: 7 May 2018

Abstract

Introduction: Clinical research has established exercise as a safe and effective intervention to counteract the adverse physical and psychological effects of cancer and its treatment. This article summarises the position of the Clinical Oncology Society of Australia (COSA) on the role of exercise in cancer care, taking into account the strengths and limitations of the evidence base. It provides guidance for all health professionals involved in the care of people with cancer about integrating exercise into routine cancer care.

Main recommendations: COSA calls for:

  • exercise to be embedded as part of standard practice in cancer care and to be viewed as an adjunct therapy that helps counteract the adverse effects of cancer and its treatment;
  • all members of the multidisciplinary cancer team to promote physical activity and recommend that people with cancer adhere to exercise guidelines; and
  • best practice cancer care to include referral to an accredited exercise physiologist or physiotherapist with experience in cancer care.

Changes in management as a result of the guideline: COSA encourages all health professionals involved in the care of people with cancer to:

  • discuss the role of exercise in cancer recovery;
  • recommend their patients adhere to exercise guidelines (avoid inactivity and progress towards at least 150 minutes of moderate intensity aerobic exercise and two to three moderate intensity resistance exercise sessions each week); and
  • refer their patients to a health professional who specialises in the prescription and delivery of exercise (ie, accredited exercise physiologist or physiotherapist with experience in cancer care).

  • 1 Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC
  • 2 Youth Cancer Services South Australia and Northern Territory, Adelaide, SA
  • 3 Peter MacCallum Cancer Centre, Melbourne
  • 4 Cancer Epidemiology and Prevention Research Group, University of Sydney, Sydney, NSW
  • 5 Melanoma Institute Australia, Sydney, NSW
  • 6 University of Queensland, Brisbane, QLD
  • 7 Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD
  • 8 University of Auckland, Auckland, NZ
  • 9 Macarthur Cancer Therapy Centre, South Western Sydney Local Health District, Sydney, NSW


Correspondence: prue.cormie@acu.edu.au

Acknowledgements: 

This position statement was developed with the support of the COSA Council and Exercise and Cancer Group. We acknowledge the feedback provided by the COSA members and affiliated organisations throughout the national consultation process. We also acknowledge the contribution of COSA staff who assisted in the development of the position statement. Anne Cust is supported by National Health and Medical Research Council and Cancer Institute NSW Career Development Fellowships. Sandra Hayes receives fellowship funding from Cancer Council Queensland.

Competing interests:

No relevant disclosures.

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Developmental dysplasia of the hip: addressing evidence gaps with a multicentre prospective international study

Emily K Schaeffer, IHDI Study Group and Kishore Mulpuri
Med J Aust 2018; 208 (8): . || doi: 10.5694/mja18.00154
Published online: 7 May 2018

Summary

 

  • There is a lack of high quality evidence available to guide clinical practice in the treatment and management of developmental dysplasia of the hip (DDH).
  • Evidence has been limited by persistent confusion on diagnostic and classification terminology, variability in surgeon decision making and a reliance on single centre, retrospective studies with small patient numbers.
  • To address gaps in knowledge regarding screening, diagnosis and management of DDH, the International Hip Dysplasia Institute began a multicentre, international prospective study on infants with hips dislocated at rest.
  • This review discusses the current state of screening, diagnostic and management practices in DDH and addresses important unanswered questions that will be critical in identifying best practices and optimising patient outcomes.
  • There is insufficient evidence to support universal ultrasound screening; instead, selective screening should be performed by 6–8 weeks of age on infants with risk factors of breech presentation, family history, or history of clinical hip instability. Follow-up of infants with risk factors and normal initial screening should be considered to at least 6 months of age.
  • Brace treatment is a sensible first-line treatment for management of dislocated hips at rest in infants < 6 months of age.
  • Early operative reduction may be considered as there is insufficient evidence to support a protective role for the ossific nucleus in the development of avascular necrosis.

 


  • 1 BC Children's Hospital, Vancouver, Canada
  • 2 University of British Columbia, Vancouver, Canada
  • 3 Orlando Health Center, Orlando, FL, USA


Correspondence: kmulpuri@cw.bc.ca

Acknowledgements: 

We thank members of the IHDI Study Group for their intellectual and data contributions to the IHDI and IHDR studies; and Niamul Quader for supplying the image and data for Box 3.

Competing interests:

We have received funding for research support from the registry seed grant, the IHDI, the Children’s Hospital Research Institute and the I'm a HIPpy Foundation.

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The rate of anterior cruciate ligament reconstruction in Australia is high: a national registry is needed

John W Orchard, Lars Engebretsen and Julian A Feller
Med J Aust 2018; 208 (8): . || doi: 10.5694/mja18.00095
Published online: 7 May 2018

Supporting a registry is an investment in the long term health of our nation

This issue of the MJA includes the results of an important study that again indicate the high rate of anterior cruciate ligament (ACL) reconstruction in Australia.1 It was already known that Australia has relatively high rates of knee ACL injuries, surgical reconstruction,2,3 and knee replacement (arthroplasty).4 The new data highlight worrying increases in the rates of both primary and revision ACL reconstruction, particularly in adolescents.1 Many factors could potentially explain an increase in the rate of ACL surgery, including more accurate diagnosis, greater access to surgery, and more people playing sport (factors that would be pleasing), but also an increase in the rate of ACL injuries per exposure (which would be disappointing). It is harder to envisage a positive explanation for an increase in the revision ACL reconstruction rate, but it is important to differentiate between contributors to failure, particularly between surgical factors (ie, techniques associated with a higher failure rate) and rehabilitation factors, such as returning to sport before adequate functional recovery has been achieved.5,6


  • 1 University of Sydney, Sydney, NSW
  • 2 University of Oslo, Oslo, Norway
  • 3 OrthoSport Victoria, Melbourne, VIC


Correspondence: johnworchard@gmail.com

Competing interests:

No relevant disclosures.

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  • 2. Janssen KW, Orchard JW, Driscoll TR, et al. High incidence and costs for anterior cruciate ligament reconstructions performed in Australia from 2003–2004 to 2007–2008: time for an anterior cruciate ligament register by Scandinavian model? Scand J Med Sci Sports 2012; 22: 495-501.
  • 3. Lekkas C, Clarnette R, Graves SE, et al. Feasibility of establishing an Australian ACL registry: a pilot study by the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). Knee Surg Sports Traumatol Arthrosc 2017; 25: 1510-1516.
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Why are so many more adolescents presenting to our emergency departments with mental health problems?

Susan M Sawyer and George C Patton
Med J Aust 2018; 208 (8): . || doi: 10.5694/mja18.00213
Published online: 7 May 2018

New data on the rise in presentations should be seen as canaries in the coal mine

Australia has in recent decades made major investments in mental health care; government expenditure has risen rapidly,1 the availability of psychological therapies has expanded,2 antidepressant use has increased,3 and the size of the mental health workforce has grown.4 There has also been a major focus on adolescents with the national rollout of Headspace centres and early psychosis programs.5 Data in two articles in this issue of the Journal, describing trends in mental health crisis presentations by adolescents to emergency departments in Australia’s two most populous states, provide an important test of the success of these investments.


  • 1 Centre for Adolescent Health, Royal Children's Hospital, Melbourne, VIC
  • 2 University of Melbourne, Melbourne, VIC
  • 3 Murdoch Children's Research Institute, Melbourne, VIC


Correspondence: susan.sawyer@rch.org.au

Competing interests:

No relevant disclosures.

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Children as haematopoietic stem cell donors: ethically challenging and legally complex

Shih-Ning Then, Ian H Kerridge and Michael Marks
Med J Aust 2018; 208 (8): . || doi: 10.5694/mja17.00758
Published online: 7 May 2018

Clinicians should be aware of the particular physical and psychological risks of haematopoietic stem cell donation in the paediatric setting, and the varying laws between states and territories

Allogeneic donor blood and bone marrow transplantation can treat a range of malignant and non-malignant diseases. For children with aplastic anaemia, severe combined immunodeficiency, leukaemia, sickle-cell disease, thalassaemia and inborn errors of metabolism, it may provide the only possibility of cure and long term survival. Although associated with considerable recipient mortality (5–12% transplant-related mortality at one year)1 and morbidity, advances in tissue typing, supportive care, patient selection, conditioning regimens and the prevention and treatment of graft-versus-host disease have dramatically improved outcomes, with up to 80% of recipients becoming long term survivors of bone marrow transplant.2


  • 1 Australian Centre for Health Law Research, Queensland University of Technology, Brisbane, QLD
  • 2 Centre for Values, Ethics and the Law in Medicine, University of Sydney, Sydney, NSW
  • 3 Royal Children's Hospital, Melbourne, VIC
  • 4 University of Melbourne, Melbourne, VIC


Correspondence: Shih-Ning.Then@qut.edu.au

Competing interests:

Shih-Ning Then is currently a member of the NHMRC Organ and Tissue Working Committee. The views expressed in this article are those of the authors and do not represent the views of the Committee.

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Parechovirus: an important emerging infection in young infants

Philip N Britton, Cheryl A Jones, Kristine Macartney and Allen C Cheng
Med J Aust 2018; 208 (8): . || doi: 10.5694/mja18.00149
Published online: 30 April 2018

Summary

 

  • Epidemics of human parechovirus (HPeV) causing disease in young children have occurred every 2 years in Australia since 2013. HPeV genotype 3 caused the epidemic from late 2017 to early 2018.
  • Most HPeV infections cause no or mild symptoms including gastroenteritis or influenza-like illness. Characteristically, young infants present with fever, irritability and on occasions a diffuse rash (“red, hot and angry” babies).
  • Severe disease can manifest as meningoencephalitis, seizures or sepsis-like presentations (including septic shock), or less common presentations including signs of surgical abdomen.
  • Testing for HPeV by specific molecular tests is indicated in children younger than 6 months of age with characteristic presentations without another confirmed diagnosis including febrile illnesses with other suggestive features (eg, rash, seizures), sepsis syndromes (including shock), and suspected meningoencephalitis (which may be detected by magnetic resonance imaging only).
  • There are no effective antiviral therapies. Treatment is primarily supportive, including management of complications.
  • Some infants with severe HPeV infection may have adverse neurodevelopment. Follow-up by a paediatrician is recommended.

 


  • 1 University of Sydney, Sydney, NSW
  • 2 The Children's Hospital at Westmead, Sydney, NSW
  • 3 University of Melbourne, Melbourne, VIC
  • 4 Melbourne Academic Centre for Health, Melbourne, VIC
  • 5 National Centre for Immunisation Research and Surveillance, Sydney, NSW
  • 6 Monash University, Melbourne, VIC


Correspondence: allen.cheng@monash.edu

Acknowledgements: 

Allen Cheng and Philip Britton are supported by NHMRC Fellowship funding. We thank the PAEDS surveillance nurses and investigators and investigators on the Australian childhood encephalitis and related studies including Julia Clark, Nigel Crawford, Jim Buttery, Christopher Blyth, Joshua Francis, Brendan McMullan, Alison Kesson, Nicole Dinsmore, Alissa McMinn, Sonia Dougherty, Carolyn Finucane and Christine Heath.

Competing interests:

No relevant disclosures.

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