To the Editor: We report a case in which the concurrent administration of colchicine and simvastatin led to significant morbidity with myopathy and intestinal dysfunction.
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- 1. Justiniano M, Dold S, Espinoza LR. Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine. J Clin Rheumatol 2007; 13: 266-268.
- 2. US Food and Drug Administration. FDA drug safety communication: revised dose limitation for Zocor (simvastatin) when taken with amiodarone. http://www.fda.gov/Drugs/DrugSafety/ucm283137.htm (accessed Apr 2012).
- 3. Edholm B. Statin-induced dysphagia [Danish]. Ugeskr Laeger 2010; 172: 544-545.
- 4. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-245.
- 5. Marfia GA, Pachatz C, Arciprete F, et al. Intestinal pseudobstruction as presenting event of fatal cerivastatin-induced myopathy. J Neurol 2003; 250: 887-888.
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