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Mainstreaming the metabolic syndrome: a definitive definition

Paul Z Zimmet, Jonathan E Shaw and K George M M Alberti
Med J Aust 2005; 183 (4): 175-176.
Published online: 15 August 2005

This new definition should assist both researchers and clinicians

The metabolic syndrome — the clustering of abdominal obesity, dyslipidaemia, hyperglycaemia and hypertension — is a major public health challenge worldwide.1,2 The metabolic syndrome is not benign; it is associated with a substantially elevated risk of type 2 diabetes (5-fold) and of cardiovascular disease (CVD) (2–3-fold),1 and its increasing prevalence could possibly reverse the gains made through recent declining CVD mortality.

  • Paul Z Zimmet1
  • Jonathan E Shaw2
  • K George M M Alberti3

  • 1 International Diabetes Institute, Caulfield, VIC.
  • 2 Imperial College, London, UK.

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