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Cardiovascular safety of rofecoxib (Vioxx): lessons learned and unanswered questions

Paul Langton, Graeme Hankey and John Eikelboom
Med J Aust 2005; 182 (4): . || doi: 10.5694/j.1326-5377.2005.tb06658.x
Published online: 21 February 2005

Paul Langton,* Graeme Hankey, John Eikelboom


  • 1 Hollywood Private Hospital, Nedlands, WA
  • 2 Stroke Unit
  • 3 Royal Perth Hospital, GPO Box X2213, Perth, WA 6847 


Correspondence: 

  • 1. Kimmel SE, Berlin JA, Reilly M, et al. Patients exposed to rofecoxib and celecoxib have different odds of non-fatal myocardial infarction. Ann Intern Med 2005; 142. Published online 7 Dec 2004. Available at: www.annals.org (accessed Dec 2004).
  • 2. Chenevard R, Hurlimann D, Bechir M, et al. Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation 2003; 107: 405-409.
  • 3. Bogaty P, Brophy JM, Noel M, et al. Impact of prolonged cyclo-oxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein. A randomised placebo-controlled study. Circulation 2004; 110: 934-939.
  • 4. Whelton A. COX-2-specific inhibitors and the kidney: effect on hypertension and oedema. J Hypertens 2002; 20 Suppl 6: S31-S35.
  • 5. Ott E, Nussmeier NA, Duke PC, et al. Efficacy and safety of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery. J Thorac Cardiovasc Surg 2003; 125: 1481-1492.
  • 6. Edwards JE, McQuay HJ, Moore RA. Efficacy and safety of Valdecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. Pain 2004; 111: 286-296.
  • 7. White WB, Strand V, Roberts R, Whelton A. Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. Am J Ther 2004; 11: 244-250.
  • 8. Battling Bextra. Meta-analyses could be taken up at February COX-2 advisory committee. Available at: www.fdaadvisorycommittee.com/FDC/AdvisoryCommittee/Committees/Arthritis+Drugs/021605_cox2day1/0216-1705_Bextra.htm (accessed Dec 2004).
  • 9. New US prescribing information for valdecoxib. Available at: www.pfizer.com/download/uspi_bextra.pdf (accessed Dec 2004).
  • 10. Zhang W, Jones A, Doherty M. Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. Ann Rheum Dis 2004; 63: 901-907.

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