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Human papillomavirus: a cause of some head and neck cancers?

Barbara R Rose, Christopher J O’Brien and Wei Li
Med J Aust 2004; 181 (8): . || doi: 10.5694/j.1326-5377.2004.tb06362.x
Published online: 18 October 2004

Establishing a causal link between HPV and certain head and neck cancers would have implications for prognosis, prevention and therapy


  • 1 Sydney Head and Neck Cancer Institute and Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW.
  • 2 Department of Infectious Diseases and Immunology, University of Sydney, NSW.


Correspondence: 

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  • 4. Garrote LF, Herrero R, Reyes RM, et al. Risk factors for cancer of the oral cavity and oropharynx in Cuba. Br J Cancer 2001; 85: 46-54.
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  • 6. Klussmann JP, Gultekin E, Weissenborn SJ, et al. Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus. Am J Pathol 2003; 162: 747-753.
  • 7. Syrjanen S. HPV infections and tonsillar carcinoma. J Clin Pathol 2004; 57: 449-455.
  • 8. Herrero R, Castellsague X, Pawlita M, et al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 2003; 95: 1772-1783.
  • 9. Klussmann JP, Weissenborn SJ, Wieland U, et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer 2001; 92: 2875-2884.
  • 10. Mellin H, Dahlgren L, Munck-Wikland E, et al. Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int J Cancer 2002; 102: 152-158.
  • 11. Li W, Thompson CH, O’Brien CJ, et al. Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil. Int J Cancer 2003; 106: 553-558.
  • 12. Schwartz SM, Daling JR, Doody DR, et al. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 1998; 90: 1626-1636.
  • 13. Li W, Thompson CH, Cossart YE, et al. The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil. Head Neck 2004; 26: 1-9.
  • 14. Li W, Thompson CH, Xin D, et al. Absence of human papillomavirus in tonsillar squamous cell carcinomas from Chinese patients. Am J Pathol 2003; 163: 2185-2189.
  • 15. Koutsky LA, Ault KA, Wheeler CM, et al. A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 2002; 347: 1645-1651.

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