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Does probiotic milk prevent infections in children attending daycare centres?

Mark G Coulthard and Craig M Mellis
Med J Aust 2004; 181 (10): 556-557.

Trial: Hatakka K, Savilahti E, Pönkä A, et al. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 2001; 322: 1327-1329.

Question

In children attending daycare centres (population), does long term consumption of probiotic milk (intervention) prevent infections (outcome)?

Mark G Coulthard, MB BS, FRACP, Paediatrician1
Craig M Mellis, MD, MPH, FRACP, Foundation Head of Medicine2
1 Paediatric Intensive Care Unit, Royal Children’s Hospital, Brisbane, QLD.
2 School of Medicine, Bond University, Gold Coast, QLD.
Article References: 
Reference Text: 
Wald ER, Guerra N, Byers C. Frequency and severity of infections in day care: three-year follow-up. J Pediatr 1991; 118: 509-514.
Reference Order: 
1
PubMed ID: 
2007922
Reference Text: 
Carabin H, Gyorkos TW, Soto JC. et al. Estimation of direct and indirect costs because of common infections in toddlers attending day care centers. Pediatrics 1999; 103: 556-564.
Reference Order: 
2
PubMed ID: 
10049956
Reference Text: 
Arvola T, Laiho K, Torkkeli S, et al. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhoea in children with respiratory infections: a randomized study. Pediatrics 1999; 104: e64.
Reference Order: 
3
PubMed ID: 
10545590
Reference Text: 
D’Souza AL, Rajkumar C, Cooke J, Bulpitt CJ. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 2002; 324: 1361-1364.
Reference Order: 
4
PubMed ID: 
12052801
Reference Text: 
Van Niel CW, Feudtner C, Garrison MM, Christakis DA. Lactobacillus therapy for acute infectious diarrhoea in children: meta-analysis. Pediatrics 2002; 109: 678-684.
Reference Order: 
5
PubMed ID: 
11927715
Reference Text: 
Hatakka K, Savilahti E, Pönkä A, et al. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomized trial. BMJ 2001; 322: 1327-1329.
Reference Order: 
6
PubMed ID: 
11387176
Reference Text: 
Wanke CA. Do probiotics prevent childhood illness? [editorial]. BMJ 2001; 322: 1318-1319.
Reference Order: 
7
PubMed ID: 
11387165

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