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Biology and therapy of multiple myeloma

Douglas E Joshua, Christian Bryant, Caroline Dix, John Gibson and Joy Ho
Med J Aust 2019; 210 (8): . || doi: 10.5694/mja2.50129
Published online: 6 May 2019

Summary

  • Genetic sequencing of the myeloma genome has not revealed a specific disease‐determining genetic alteration.
  • Multiple disease subclones exist at diagnosis and vary in clinical importance with time and drug sensitivity.
  • New diagnostic criteria have identified indications for early introduction of therapy.
  • Autologous stem cell transplantation remains an essential component of therapy in young and fit patients.
  • The use of continual suppressive (maintenance) therapy has been established as an important component in therapy.
  • Immune therapies and the harnessing of the innate immune system offer great promise for future treatments.
  • Since 2005, quality of life, supportive therapies, and survival have dramatically improved over a decade of remarkable progress.
  • The common manifestations of multiple myeloma, such as bone pain, fatigue and weight loss, may be non‐specific and are often initially ignored or missed by patients and medical practitioners.
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Advances in stroke medicine

Bruce CV Campbell
Med J Aust 2019; 210 (8): . || doi: 10.5694/mja2.50137
Published online: 6 May 2019

Summary

  • In recent years, reperfusion therapies such as intravenous thrombolysis and endovascular thrombectomy for ischaemic stroke have dramatically reduced disability and revolutionised stroke management.
  • Thrombolysis with alteplase is effective when administered to patients with potentially disabling stroke, who are not at high risk of bleeding, within 4.5 hours of the time the patient was last known to be well. Emerging evidence suggests that other thrombolytics such as tenecteplase may be even more effective. Treatment may be possible beyond 4.5 hours in patients selected using brain imaging.
  • Endovascular thrombectomy (via angiography) effectively reduces risk of death or dependency in patients with large vessel occlusion (internal carotid, proximal middle cerebral and basilar arteries) if applied within 6 hours of the time they were last known to be well.
  • Endovascular thrombectomy is also beneficial 6–24 hours from the last known well time in selected patients with favourable brain imaging. Thus, some patients with wake‐up stroke are now treatable, and protocols for stroke need to include computed tomography (CT) perfusion scan and CT angiography as routine, in addition to the non‐contrast CT brain scan.
  • Optimised pre‐hospital and emergency department systems (eg, code stroke response teams, pre‐notification by ambulance, direct transport from triage to CT scanner) are essential to maximise the benefit of these strongly time‐dependent therapies. Telemedicine is increasingly providing specialist guidance for these more complex treatment decisions in rural areas.
  • Important developments in secondary stroke prevention include the use of direct oral anticoagulants or left atrial appendage occlusion for atrial fibrillation, and endovascular closure of patent foramen ovale.

  • Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC


Correspondence: Bruce.Campbell@mh.org.au

Competing interests:

Bruce Campbell has received research support from the National Health and Medical Research Council (GNT1043242, GNT1035688), the Royal Australasian College of Physicians, the Royal Melbourne Hospital Foundation, the National Heart Foundation and the Stroke Foundation. He has received unrestricted grant funding for the EXTEND‐IA trial to the Florey Institute of Neuroscience and Mental Health from Medtronic. He co‐chaired the 2017 Australian Stroke Guidelines content working party.

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Blindness and acute pancreatitis: Purtscher‐like retinopathy

Anthony Yao and Bob Wang
Med J Aust 2019; 210 (8): . || doi: 10.5694/mja2.50135
Published online: 6 May 2019


  • Austin Health, Melbourne, VIC


Correspondence: anthony.yao@gmail.com

Competing interests:

No relevant disclosures.

  • 1. Miguel AIM, Henriques F, Azevedo LFR, et al. Systematic review of Purtscher's and Purtscher‐like retinopathies. Eye 2013; 27: 1–13.
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Mycobacterial mimicry in a man from Myanmar

David WJ Griffin, G Khai Lin Huang, Philippe Lachapelle, Steven YC Tong and Siddhartha Mahanty
Med J Aust 2019; 210 (8): . || doi: 10.5694/mja2.50133
Published online: 6 May 2019

A 26‐year‐old refugee from Myanmar was referred to the infectious diseases unit of an Australian teaching hospital for assessment of suspected recurrent pulmonary tuberculosis (TB). He had arrived in Australia 3 months earlier, after spending the preceding 5 years in Malaysia. He was diagnosed with presumed pulmonary TB in Malaysia in 2013, in the context of a productive cough and suspicious chest x‐ray findings, without microbiological confirmation. He completed treatment with 6 months of first line anti‐TB therapy (2 months of rifampicin, isoniazid, pyrazinamide and ethambutol, followed by 4 months of rifampicin and isoniazid).


  • 1 Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, VIC
  • 2 Royal Melbourne Hospital, Melbourne, VIC
  • 3 Menzies School of Health Research and Royal Darwin Hospital, Darwin, NT


Correspondence: davidwjgriffin@gmail.com

Acknowledgements: 

David Griffin and Khai Huang contributed equally to the authorship of this manuscript. We would like to thank the staff in the Department of Microbiology at Melbourne Health.

Competing interests:

No relevant disclosures.

  • 1. Foodborne Diseases Burden Epidemiology Reference Group 2007‐2015. WHO estimates of the global burden of foodborne diseases. Geneva: World Health Organization, 2015. http://www.who.int/foodsafety/publications/foodborne_disease/fergreport/en/ (viewed Oct 2018).
  • 2. Procop GW. North American paragonimiasis (caused by Paragonimus kellicotti) in the context of global paragonimiasis. Clin Microbiol Rev 2009; 22: 415–446.
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  • 4. Seon HJ, Kim YI, Lee JH, et al. Differential chest computed tomography findings of pulmonary parasite infestation between the paragonimiasis and nonparagonimiatic parasite infestation. J Comput Assist Tomog 2015; 39: 956–961.
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Acute kidney injury in Indigenous Australians in the Kimberley: age distribution and associated diagnoses

Joseph V Mohan, David N Atkinson, Johan B Rosman and Emma K Griffiths
Med J Aust 2019; 211 (1): . || doi: 10.5694/mja2.50061
Published online: 29 April 2019

Abstract

Objective: To describe the frequencies of acute kidney injury (AKI) and of associated diagnoses in Indigenous people in a remote Western Australian region.

Design: Retrospective population‐based study of AKI events confirmed by changes in serum creatinine levels.

Setting, participants: Aboriginal and Torres Strait Islander residents of the Kimberley region of Western Australia, aged 15 years or more and without end‐stage kidney disease, for whom AKI between 1 June 2009 and 30 May 2016 was confirmed by an acute rise in serum creatinine levels.

Main outcome measures: Age‐specific AKI rates; principal and other diagnoses.

Results: 324 AKI events in 260 individuals were recorded; the median age of patients was 51.8 years (IQR, 43.9–61.0 years), and 176 events (54%) were in men. The overall AKI rate was 323 events (95% CI, 281–367) per 100 000 population; 92 events (28%) were in people aged 15–44 years. 52% of principal diagnoses were infectious in nature, including pneumonia (12% of events), infections of the skin and subcutaneous tissue (10%), and urinary tract infections (7.7%). 80 events (34%) were detected on or before the date of admission; fewer than one‐third of discharge summaries (61 events, 28%) listed AKI as a primary or other diagnosis.

Conclusion: The age distribution of AKI events among Indigenous Australians in the Kimberley was skewed to younger groups than in the national data on AKI. Infectious conditions were common in patients, underscoring the significance of environmental determinants of health. Primary care services can play an important role in preventing community‐acquired AKI; applying pathology‐based criteria could improve the detection of AKI.

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  • 1 The University of Western Australia, Perth, WA
  • 2 Rural Clinical School of Western Australia, University of Western Australia, Broome, WA
  • 3 Curtin University, Perth, WA
  • 4 Kimberley Aboriginal Medical Services, Broome, WA



Acknowledgements: 

We thank Julia Marley (Kimberley Research, University of Western Australia) for critically reviewing our manuscript.

Competing interests:

No relevant disclosures.

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Traumatic spinal cord injury in Victoria, 2007–2016

Ben Beck, Peter A Cameron, Sandra Braaf, Andrew Nunn, Mark C Fitzgerald, Rodney T Judson, Warwick J Teague, Alyse Lennox, James W Middleton, James E Harrison and Belinda J Gabbe
Med J Aust 2019; 210 (8): . || doi: 10.5694/mja2.50143
Published online: 29 April 2019

Abstract

Objective: To investigate trends in the incidence and causes of traumatic spinal cord injury (TSCI) in Victoria over a 10‐year period.

Design, setting, participants: Retrospective cohort study: analysis of Victorian State Trauma Registry (VSTR) data for people who sustained TSCIs during 2007–2016.

Main outcomes and measures: Temporal trends in population‐based incidence rates of TSCI (injury to the spinal cord with an Abbreviated Injury Scale [AIS] score of 4 or more).

Results: There were 706 cases of TSCI, most the result of transport events (269 cases, 38%) or low falls (197 cases, 28%). The overall crude incidence of TSCI was 1.26 cases per 100 000 population (95% CI, 1.17–1.36 per 100 000 population), and did not change over the study period (incidence rate ratio [IRR], 1.01; 95% CI, 0.99–1.04). However, the incidence of TSCI resulting from low falls increased by 9% per year (95% CI, 4–15%). The proportion of TSCI cases classified as incomplete tetraplegia increased from 41% in 2007 to 55% in 2016 (P < 0.001). Overall in‐hospital mortality was 15% (104 deaths), and was highest among people aged 65 years or more (31%, 70 deaths).

Conclusions: Given the devastating consequences of TSCI, improved primary prevention strategies are needed, particularly as the incidence of TSCI did not decline over the study period. The epidemiologic profile of TSCI has shifted, with an increasing number of TSCI events in older adults. This change has implications for prevention, acute and post‐discharge care, and support.

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  • 1 Monash University, Melbourne, VIC
  • 2 The Alfred Hospital, Melbourne, VIC
  • 3 Victorian Spinal Cord Service, Austin Hospital, Melbourne, VIC
  • 4 National Trauma Research Institute, Melbourne, VIC
  • 5 Royal Melbourne Hospital, Melbourne, VIC
  • 6 University of Melbourne, Melbourne, VIC
  • 7 Royal Children's Hospital, Melbourne, VIC
  • 8 Murdoch Children's Research Institute, Melbourne, VIC
  • 9 Kolling Institute, University of Sydney, Sydney, NSW
  • 10 Agency for Clinical Innovation, Sydney, NSW
  • 11 Research Centre for Injury Studies, Flinders University, Adelaide, SA
  • 12 Health Data Research UK, Swansea University Medical School, Swansea University, Swansea, United Kingdom


Correspondence: ben.beck@monash.edu

Acknowledgements: 

We thank the Victorian State Trauma Outcome Registry and Monitoring (VSTORM) group for providing Victorian State Trauma Registry data. We also thank Sue McLellan for her assistance with providing the data. The VSTR is funded by the Department of Health and Human Services, Victoria and the Transport Accident Commission. Ben Beck was supported by an Australian Research Council Discovery Early Career Researcher Award Fellowship (DE180100825). Peter Cameron was supported by a National Health and Medical Research Council Practitioner Fellowship (545926). Warwick Teague's role as director of trauma services was supported by a grant from the Royal Children's Hospital Foundation. Belinda Gabbe was supported by an Australian Research Council Future Fellowship (FT170100048).

Competing interests:

No relevant disclosures.

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Early success with room for improvement: influenza vaccination of young Australian children

Frank H Beard, Alexandra J Hendry and Kristine Macartney
Med J Aust 2019; 210 (11): . || doi: 10.5694/mja2.50141
Published online: 29 April 2019
Correction(s) for this article: Erratum | Published online: 23 September 2025

Immunisation providers should offer annual influenza vaccination for children aged 6 months to 5 years and report it to the Australian Immunisation Register


  • 1 National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Sydney, NSW
  • 2 University of Sydney, Sydney, NSW



Competing interests:

No relevant disclosures.

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Qualified privilege legislation to support clinician quality assurance: balancing professional and public interests

Susannah Ahern, Ingrid Hopper and Erwin Loh
Med J Aust 2019; 210 (8): . || doi: 10.5694/mja2.50124
Published online: 22 April 2019

A review of the legislation may be warranted to assess the balance between professional and public interests

Patient health‐related datasets are protected by national and state‐based privacy laws which establish requirements for data security that safeguard identified patient information.1,2,3 Nevertheless, these data may potentially be accessed by third parties in accordance with the law — for example, in connection with freedom of information requests or legal proceedings — by statutory bodies such as the Australian Health Practitioner Regulatory Agency, or by jurisdictional health complaints commissions. Patient information from health service medical records is regularly used in medico‐legal proceedings, a recent significant example of which was the Bawa‐Garba case in the United Kingdom,4 discussed below.


  • Monash University, Melbourne, VIC


Correspondence: susannah.ahern@monash.edu

Competing interests:

No relevant disclosures.

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Updated Australian consensus statement on management of inherited bleeding disorders in pregnancy

Scott Dunkley, Julie A Curtin, Anthony J Marren, Robert P Heavener, Simon McRae and Jennifer L Curnow
Med J Aust 2019; 210 (7): . || doi: 10.5694/mja2.50123
Published online: 15 April 2019

Abstract

Introduction: There have been significant advances in the understanding of the management of inherited bleeding disorders in pregnancy since the last Australian Haemophilia Centre Directors’ Organisation (AHCDO) consensus statement was published in 2009. This updated consensus statement provides practical information for clinicians managing pregnant women who have, or carry a gene for, inherited bleeding disorders, and their potentially affected infants. It represents the consensus opinion of all AHCDO members; where evidence was lacking, recommendations have been based on clinical experience and consensus opinion.

Main recommendations: During pregnancy and delivery, women with inherited bleeding disorders may be exposed to haemostatic challenges. Women with inherited bleeding disorders, and their potentially affected infants, need specialised care during pregnancy, delivery, and postpartum, and should be managed by a multidisciplinary team that includes at a minimum an obstetrician, anaesthetist, paediatrician or neonatologist, and haematologist. Recommendations on management of pregnancy, labour, delivery, obstetric anaesthesia and postpartum care, including reducing and treating postpartum haemorrhage, are included. The management of infants known to have or be at risk of an inherited bleeding disorder is also covered.

Changes in management as a result of this statement: Key changes in this update include the addition of a summary of the expected physiological changes in coagulation factors and phenotypic severity of bleeding disorders in pregnancy; a flow chart for the recommended clinical management during pregnancy and delivery; guidance for the use of regional anaesthetic; and prophylactic treatment recommendations including concomitant tranexamic acid.


  • 1 Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW
  • 2 The Children's Hospital at Westmead, Sydney, NSW
  • 3 Australian Haemophilia Centres Directors’ Organisation, Melbourne, VIC
  • 4 Royal Prince Alfred Hospital, Sydney, NSW
  • 5 Royal Adelaide Hospital, Adelaide, SA
  • 6 Haemophilia Treatment Centre, Westmead Hospital, Sydney, NSW


Correspondence: scottmdunkley@gmail.com

Acknowledgements: 

We are grateful to Steph P'ng, John Rowell, Tim Brighton, Huyen Tran and Ian Douglas for their helpful feedback and comments. We acknowledge Ruth Hadfield for medical writing and editing assistance.

Competing interests:

No relevant disclosures.

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Resilient health systems: preparing for climate disasters and other emergencies

Gerard J FitzGerald, Anthony Capon and Peter Aitken
Med J Aust 2019; 210 (7): . || doi: 10.5694/mja2.50115
Published online: 15 April 2019

A system that integrates all aspects of health care is essential for facing future challenges

After another Australian summer of record‐breaking temperatures, bushfires, floods and widespread drought, it is clear that our health systems should be strengthened to cope with the challenges of climate change. We must also reduce the carbon footprint of health care,1 and continue to advocate that Australia play its part in dealing with the fundamental causes of climate change. In May, the 21st biennial congress of the World Association for Disaster and Emergency Medicine (WADEM) will be hosted by Brisbane. The congress will bring together investigators and practitioners from around the world to discuss disaster health care, future risks, community vulnerabilities, and the strategies required by resilient health systems.


  • 1 Queensland University of Technology, Brisbane, QLD
  • 2 Sydney School of Public Health, University of Sydney, Sydney, NSW
  • 3 Health Disaster Management Unit, Queensland Health, Brisbane, QLD


Correspondence: gj.fitzgerald@qut.edu.au

Competing interests:

No relevant disclosures.

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