Chemical analysis of fresh and aged Australian e‐cigarette liquids

Jody Morgan, Alison Jones and Celine Kelso
Med J Aust 2022; 216 (7): . || doi: 10.5694/mja2.51466
Published online: 18 April 2022

To the Editor: In their recent article, Larcombe and colleagues1 describe the analysis of 65 electronic cigarette fluid samples. The gas chromatography mass spectrometry method, as described in the Supporting Information, used “the ratio between the peak area corresponding to the fragment with the highest signal‐to‐noise ratio … and the peak area of the internal standard” for quantification.1 Direct comparison of the peaks for the analyte of interest and the internal standard does not take into account differences in response factor and/or ionisation efficiency for the different molecules. For accurate quantification, individual calibration curves should be prepared for all molecules of interest.

  • Jody Morgan1
  • Alison Jones2,3
  • Celine Kelso2,4

  • 1 University of Sydney, Sydney, NSW
  • 2 University of Wollongong, Wollongong, NSW
  • 3 Western, Australia, Department of Health, Perth, WA
  • 4 Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW



We acknowledge seed funding from the Faculty of Science, Medicine and Health at the University of Wollongong.

Competing interests:

No relevant disclosures.


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