A surveillance clinic for children and adolescents with, or at risk of, hereditary cancer predisposition syndromes

Nicholas Leedman, Murray Princehorn, Nicholas Gottardo, Claire Franklin, Rebecca D'Souza and Catherine E Kiraly‐Borri
Med J Aust 2021; 214 (7): . || doi: 10.5694/mja2.51002
Published online: 19 April 2021

To the Editor: Hereditary cancer predisposition syndromes (HCPS) account for at least 10% of paediatric cancers.1 Li‐Fraumeni syndrome (LFS) is a dominant HCPS caused by mutations in the TP53 gene and is associated with an 80–90% lifetime risk of cancer, commencing in infancy.2 Children of affected individuals are at 50% risk of inheriting the family mutation.

  • Nicholas Leedman1
  • Murray Princehorn2
  • Nicholas Gottardo1,3
  • Claire Franklin2
  • Rebecca D'Souza4
  • Catherine E Kiraly‐Borri4

  • 1 University of Western Australia, Perth, WA, Australia
  • 2 Perth Children’s Hospital, Perth, WA, Australia
  • 3 Telethon Kids Cancer Centre, Brain tumour Research Program, Telethon Kids Institute, Perth, WA, Australia
  • 4 Genetic Services of Western Australia, Perth, WA, Australia

Competing interests:

No relevant disclosures.


remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.