Birthweight and fasting glucose and insulin levels: results from the Aboriginal Birth Cohort Study

Susan M Sayers, Susan A Mott, Kay D Mann, Mark S Pearce and Gurmeet R Singh
Med J Aust 2013; 199 (2): 112-116. || doi: 10.5694/mja13.10200
  • Susan M Sayers1
  • Susan A Mott2
  • Kay D Mann3
  • Mark S Pearce3
  • Gurmeet R Singh1

  • 1 Menzies School of Health Research, Darwin, NT.
  • 2 Centre for Chronic Disease, School of Medicine, University of Queensland, Brisbane, QLD.
  • 3 Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.



We thank the adolescents belonging to the cohort for their continued cooperation, and everyone who helped in the urban and rural locations. This work was supported by the National Health and Medical Research Council of Australia.

Competing interests:

No relevant disclosures.

  • 1. Barker DJP. Mother, babies, and health in later life. 2nd ed. Edinburgh: Churchill Livingstone, 1998.
  • 2. Godfrey KM, Lillycorp KA, Burdge GC, et al. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res 2007; 61 (5 Pt 2): 5R-10R.
  • 3. Leeds K, Gourley M, Laws P, et al. Indigenous mothers and their babies, Australia 2001–2004. Canberra: AIHW, 2007. (AIHW Cat. No. PER 38; Perinatal Statistics Series No. 19.)
  • 4. Sayers SM, Powers JR. Birth size of Australian Aboriginal babies. Med J Aust 1993; 159: 586-591.
  • 5. Australian Bureau of Statistics, Australian Institute of Health and Welfare. The health and welfare of Australia's Aboriginal and Torres Strait Islander peoples. Canberra: Commonwealth of Australia, 2008. (ABS Cat. No. 4704.0; AIHW Cat. No. IHW 21.)
  • 6. Fearnley E, Li SQ, Guthridge S. Trends in chronic disease mortality in the Northern Territory Aboriginal population, 1997–2004: using underlying and multiple causes of death. Aust N Z J Public Health 2009; 33: 551-555.
  • 7. Singh GR, Hoy WE. The association between birthweight and current blood pressure; a cross-sectional study in an Australian Aboriginal community. Med J Aust 2003; 179: 532-535. <MJA full text>
  • 8. Hoy WE, Nicol JL. Birthweight and natural deaths in a remote Australian Aboriginal community. Med J Aust 2010; 192: 14-19. <MJA full text>
  • 9. Sayers SM, Mackerras D, Singh G, et al. An Australian Aboriginal birth cohort: a unique resource for a life course study of an Indigenous population. BMC Int Health Hum Rights 2003; 3: 1.
  • 10. Sayers S, Singh G, Mackerras D, et al. Australian Aboriginal Birth Cohort study: follow-up processes at 20 years. BMC Int Health Hum Rights 2009; 9: 23.
  • 11. Dubowitz LMS, Dubowitz V. A clinical manual: gestational age of the newborn. Philippines: Addison-Wesley, 1977.
  • 12. Guaran RL, Wein P, Sheedy M, et al. Update of growth percentiles for infants born in an Australian population. Aust N Z J Obstet Gynaecol 1994; 34: 39-50.
  • 13. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
  • 14. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Advance Data 2000; 314: 1-27.
  • 15. World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. (WHO Technical Report Series No. 854.) Geneva: WHO, 1995.
  • 16. Lucas A, Fewtrell MS, Cole TJ. Fetal origins of adult disease revisited. BMJ 1999; 319: 245-249.
  • 17. Sayers S, Singh G, Mott S, et al. Relationships of birth weight and biomarkers of chronic disease in childhood: Aboriginal Birth Cohort Study 1987–2001. Paediatr Perinat Epidemiol 2009; 23: 548-556.
  • 18. Braveman PA, Cubbin C, Egerter S, et al. Socioeconomic status in health research: one size does not fit all. JAMA 2005; 294: 2879-2888.
  • 19. McNamara BJ, Gubhaju L, Chamberlain C, et al. Early life influences on cardio-metabolic disease risk in aboriginal populations — what is the evidence? A systematic review of longitudinal and case-control studies. Int J Epidemiol 2012; 41: 1661-1682.
  • 20. Norris SA, Osmond C, Gigante D, et al. Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts. Diabetes Care 2012; 35: 72-79.
  • 21. Stein AD, Conlisk A, Torun B, et al. Cardiovascular disease risk factors are related to adult adiposity but not birth weight in young Guatemalan adults. J Nutr 2002; 132: 2208-2214.
  • 22. Pearce MS, Unwin NC, Parker L, et al. Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle Thousand Families Study. Diabetes Metab Res Rev 2006; 22: 118-125.
  • 23. Pearce MS, Unwin NC, Relton CL. Lifecourse determinants of fasting and post-challenge glucose at age 50 years: the Newcastle Thousand Families Study. Eur J Epidemiol 2005; 20: 915-923.
  • 24. Whincup PH, Cook DG, Adshead F, et al. Childhood size is more strongly related than size at birth to glucose and insulin levels in 10–11-year-old children. Diabetologia 1997; 40: 319-326.


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