MJA
MJA InSight
MJA Careers
Notable cases

BK virus-associated progressive multifocal leukoencephalopathy

Kathryn L Daveson, Chong W Ong, Scott Bowden, Mark E Koina and Lavinia A Hallam
Med J Aust 2013; 198 (4): 216-218.
doi:
10.5694/mja12.10072

Progressive multifocal leukoencephalopathy (PML) is associated with the polyomavirus JC virus, while BK virus is causative of polyomavirus-associated nephropathy. We report the first definitive case of BK virus-associated PML. This case highlights the importance of biopsy for aetiologic diagnosis in the setting of viral latency and the absence of clear T-cell dysfunction or biologic therapy.

Kathryn L Daveson, MB BS, MPH, FRACP, Infectious Diseases Physician1
Chong W Ong, MB BS(Hons), FRACP, FRCPA, Microbiology Fellow1
Scott Bowden, PhD, Senior Scientist2
Mark E Koina, BSc(Hons), PhD, Electron Microscopist3
Lavinia A Hallam, MB BCh, FRCPath, FRCPA, Pathologist3
1 Department of Infectious Diseases, Canberra Hospital and Health Services, Canberra, ACT.
2 Molecular Microbiology Laboratory, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC.
3 Department of Anatomical Pathology, Canberra Hospital and Health Services, Canberra, ACT.
Article References: 
Reference Text: 
Arthur RR, Dagostin S, Shah KV. Detection of BK virus and JC virus in urine and brain tissue by the polymerase chain reaction. J Clin Microbiol 1989; 27: 1174-1179.
Reference Order: 
1
PubMed ID: 
2546971
Reference Text: 
Egli A, Infanti L, Dumoulin A, et al. Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis 2009; 199: 837-946.
Reference Order: 
2
PubMed ID: 
19434930
Reference Text: 
Da Silva RL. Polyoma BK virus: an emerging opportunistic infectious agent of the human central nervous system. Braz J Infect Dis 2011; 15: 276-284.
Reference Order: 
3
PubMed ID: 
21670931
Reference Text: 
Behzad-Behbahani A, Klapper PE, Vallely PJ, et al. BK virus DNA in CSF of immunocompetent and immunocompromised patients. Arch Dis Child 2003; 88: 174-175.
Reference Order: 
4
PubMed ID: 
12538331
Reference Text: 
Vallbracht A, Lohler J, Grossman J, et al. Disseminated BK type polyomavirus infection in an AIDS patient associated with central nervous system disease. Am J Pathol 1993; 143: 29-39.
Reference Order: 
5
PubMed ID: 
8391217
Reference Text: 
Bratt G, Hammarin AL, Grandien M, et al. BK virus as the cause of meningoencephalitis, retinitis, and nephritis in a patient with AIDS. AIDS 1999; 13: 1071-1075.
Reference Order: 
6
PubMed ID: 
10397537
Reference Text: 
Friedman DP, Flanders AE. MR imaging of BK virus encephalitis. Am J Neuroradiol 2006; 27: 1016-1018.
Reference Order: 
7
PubMed ID: 
16687535
Reference Text: 
Voltz R, Jager G, Seelos K, et al. BK virus encephalitis in an immunocompetent patient. Arch Neurol 1996; 53: 101-103.
Reference Order: 
8
PubMed ID: 
8599551
Reference Text: 
Hix JK, Braun WE, Isada CM. Delirium in a renal transplant recipient associated with BK virus in the cerebrospinal fluid. Transplantation 2004; 78: 1407-1408.
Reference Order: 
9
PubMed ID: 
15548984
Reference Text: 
Cabrejo L, Diop M, Blohorn-Sense A, et al. Progressive BK virus associated multifocal leukoencephalopathy in an immunocompromised patient treated with corticosteroids. Revue Neurologique 2005; 161: 326-330.
Reference Order: 
10
PubMed ID: 
15800455
Reference Text: 
Haider S, Nafziger D, Gutierrez JA, et al. Progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia: a case report and review of reported cases. Clin Infect Dis 2000; 31: E20-E22.
Reference Order: 
11
PubMed ID: 
11049808
Reference Text: 
Langer-Gould A, Atlas SW, Green AJ, et al. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 2005; 353: 375-381.
Reference Order: 
12
PubMed ID: 
15947078
Reference Text: 
Chemicon International. Mouse anti-BK virus large T antigen monoclonal antibody. 2004. http://www.millipore.com/publications.nsf/a73664f9f981a f8c852569b9005b4eee/a9fae3f5c328451f852573060074a 840/$FILE/MAB8505.pdf (accessed Feb 2012).
Reference Order: 
13

The full contents of this page are only available to subscribers.