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Does preoperative radiotherapy improve outcome in patients with resectable rectal cancer?

Michael J Veness
Med J Aust 2002; 177 (10): 563-564.
Question

Should patients with resectable rectal cancer receive preoperative pelvic radiotherapy?

Trial details

Design:

Multicentre international randomised controlled trial.

Setting:

Michael J Veness, MB BS, MMed(ClinEpi),FRANZCR, Radiation Oncologist, and Clinical Lecturer, Sydney University
Department of Radiation Oncology, Westmead Hospital, Westmead, NSW.
Article References: 
Reference Text: 
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6689962
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Ooi BS, Tjandra JJ, Green MD. Morbidities of adjuvant chemotherapy and radiotherapy for resectable rectal cancer. Dis Colon Rectum 1999; 42: 403-441.
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10223765
Reference Text: 
Stevens G, Firth I, Solomon M, et al. Rectal cancer: changing patterns of referral for radiation therapy 1982–1997. Aust N Z J Surg 2000; 70: 553-559.
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10945546
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Kockering F, Reymond MA, Altendorf-Hofmann A, et al. Influence of surgery on metachronous distant metastases and survival in rectal cancer. J Clin Oncol 1998; 16: 324-329.
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9440760
Reference Text: 
Kapiteijn E, Marijnen CAM, Nagtegaal ID, et al, for the Dutch Colorectal Cancer Group. Acute side effects and complications after short term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a multicenter randomized trial. J Clin Oncol 2002; 20: 817-825.
Reference Order: 
5
PubMed ID: 
11821466
Reference Text: 
Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 1997; 336: 980- 987.
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9091798
Reference Text: 
Sobin LH, Wittekind C, editors. TMN classification of malignant tumours. UICC International Union Against Cancer. New York: Wiley-Liss, 1997: 67-68.
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Reference Text: 
National Health and Medical Research Council. Guidelines for the prevention, early detection and management of colorectal cancer. Canberra: NHMRC 1999.
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Reference Text: 
Krook JE, Moertel CG, Gunderson LL, et al. Effective surgical adjuvant therapy for high risk rectal cancer. N Engl J Med 1991; 324: 709-715.
Reference Order: 
9
PubMed ID: 
1997835

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