Cervical cancer associated with human papillomavirus (HPV) affects approximately 1000 Australian women each year, causing about 300 deaths.1 The newly licensed HPV vaccines Gardasil (CSL Limited), a quadrivalent vaccine (4vHPV), and Cervarix (GlaxoSmithKline Vaccines), a bivalent vaccine (2vHPV), induce protection against the two most common strains of HPV, which cause 70% of all cervical cancers.2,3
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- 1. Australian Institute of Health and Welfare. Cancer in Australia 2001. Canberra: AIHW, 2004. (AIHW Cat. No. CAN 23; Cancer series No. 28.)
- 2. Harper DM, Franco EL, Wheeler CM, et al. Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial. Lancet 2006; 367: 1247-1255.
- 3. Future II Study Group. Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N Engl J Med 2007; 356: 1915-1927.
- 4. Joura EA, Leodolter S, Hernandez-Avila M, et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693-1702.
- 5. Clements CJ. Mass psychogenic illness after vaccination. Drug Saf 2003; 26: 599-604.
- 6. Tanne JH. Questions over human papillomavirus vaccine in the US and Australia. BMJ 2007; 334: 1182-1183.
- 7. Clements CJ. Gardasil and mass psychogenic illness. Aust N Z J Public Health 2007; 31: 387.
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GlaxoSmithKline supported Jim Buttery’s travel to speak at an international meeting by payment to the Murdoch Childrens Research Institute.