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Screening decreases prostate cancer death: first analysis of the1988  Quebec Prospective Randomized Controlled Trial

Alexandra L Barratt and Alan S Coates
Med J Aust 2004; 181 (4) || doi: 10.5694/j.1326-5377.2004.tb06240.x
Published online: 16 August 2004

Does early detection (by prostate-specific antigen [PSA] testing and digital rectal examination) and treatment of prostate cancer reduce the risk of death from prostate cancer among men aged 45–80 years invited to screening?

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  • 1 School of Public Health, University of Sydney, NSW.
  • 2 The Cancer Council Australia, Sydney, NSW.


Correspondence: 

Acknowledgements: 

We would like to thank Professor Les Irwig for comments on earlier drafts of this article.

Competing interests:

None identified.

  • 1. Barratt AL, Irwig L, Glasziou P, et al. Users’ guides to the medical literature. XVII. How to use guidelines and recommendations about screening. JAMA 1999; 281: 2029-2034.
  • 2. Shultz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995; 273: 408-412.
  • 3. Cuzick J, Edwards R, Segnan N. Adjusting for non-compliance and contamination in randomized clinical trials. Stat Med 1997; 16: 1017-1029.
  • 4. Glasziou P. Meta-analysis adjusting for compliance: the example of screening for breast cancer. J Clin Epidemiol 1992; 45: 1251-1256.

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