Eczema coxsackium

Hsing‐Jou Su and Chun‐Bing Chen
Med J Aust 2021; 215 (9): . || doi: 10.5694/mja2.51297
Published online: 1 November 2021

A 6‐month‐old female infant with atopic dermatitis presented with multiple erythematous papules and vesicles with crusts on the perioral area, trunk and extremities (Figure). The distribution of the new skin eruptions was almost on the same areas of atopic dermatitis. She was afebrile with mildly decreased appetite and activity. The polymerase chain reaction (PCR) tests for throat and vesicle fluid were positive for coxsackievirus A6 but negative for herpes simplex virus, confirming diagnosis of eczema coxsackium. After topical corticosteroid, topical antibiotics, and adequate hydration, the skin lesions resolved within 2 weeks. Eczema coxsackium is commonly caused by coxsackievirus A6 in patients with atopic dermatitis.1 Differential diagnoses include varicella zoster infection, eczema herpeticum, and bullous impetigo. PCR testing for enterovirus detection of the vesicle fluid helps to differentiate eczema coxsackium from eczema herpeticum. Early diagnosis can prevent inappropriate use of antibiotics or acyclovir.2

  • 1 Chang Gung Memorial Hospital, Linkou, Taiwan
  • 2 Chang Gung Memorial Hospital, Taipei, Taiwan
  • 3 Chang Gung Memorial Hospital, Keelung, Taiwan
  • 4 Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan
  • 5 Chang Gung University, Taoyuan, Taiwan
  • 6 Graduate Institute of Clinical Medical Sciences, Chang Gung University, Keelung, Taiwan
  • 7 Xiamen Chang Gung Hospital, Xiamen, China
  • 8 Immune‐Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan


Competing interests:

No relevant disclosures.

  • 1. Horsten HH, Kemp M, Fischer TK, et al. Atypical hand, foot, and mouth disease caused by coxsackievirus A6 in Denmark: a diagnostic mimicker. Acta Derm Venereol 2018; 98: 350–354.
  • 2. Hoffmann AJ, Latrous M, Lam JM. Atypical hand‐foot‐and‐mouth disease. CMAJ 2020; 192: E69.


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