Dementia of the personality

Peter J Nestor*
Med J Aust 2017; 207 (7): . || doi: 10.5694/mja17.00667
Published online: 2 October 2017

Therapeutic development should not forget the symptoms

According to the 1983 edition of the Oxford textbook of psychiatry, “There are no specific clinical features to separate [frontotemporal dementia] from Alzheimer’s, and the distinction is generally made at autopsy not in life”.1 That was a popular view at the time — dementias are clinically all the same but sometimes pathologically different. Since then, the growth in understanding of non-Alzheimer degenerative dementias has been enormous. Careful clinical characterisation has, in turn, paved the way for numerous fundamental discoveries in pathology and genetics.

  • Peter J Nestor*

  • German Center for Neurodegenerative Diseases, Magdeburg, Germany


* From November 2017, I will be based at the Queensland Brain Institute, University of Queensland and at the Mater Hospital Brisbane.

Competing interests:

No relevant disclosures.


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