Clozapine-induced maculopathy

Jessica Y Tong, Amy Pai and Stephanie H Young
Med J Aust 2017; 207 (7): . || doi: 10.5694/mja17.00452
Published online: 2 October 2017

We thank Mack and Symons for their comments on our article.1 Our patient presented with bilateral asymmetric macular pigmentary changes, secondary to disturbances of the retinal pigment epithelium (RPE). Clinical examination findings corresponded with visual field and electrophysiology tests.

  • 1 Westmead Hospital, Sydney, NSW
  • 2 Concord Repatriation General Hospital, Sydney, NSW


Competing interests:

No relevant disclosures.

  • 1. Tong JY, Pai A, Heydon P, Young SH. Clozapine-induced maculopathy. Med J Aust 2017; 206: 246. <MJA full text>
  • 2. Borodoker N, Del Priore LV, De A Carvalho C, Yannuzzi LA. Retinopathy as a result of long-term use of thioridazine. Arch Ophthalmol 2002; 120: 994-995.
  • 3. Lal S, Bloom D, Silver B, Desjardins B, et al. Replacement of chlorpromazine with other neuroleptics: effect on abnormal skin pigmentation and ocular changes. J Psychiatr Neurosci 1993; 18: 173-177.
  • 4. Fornaro P, Calabria G, Corallo G, Picotti GB. Pathogenesis of degenerative retinopathies induced by thioridazine and other antipsychotics: a dopamine hypothesis. Doc Ophthalmol 2002; 105: 41-49.
  • 5. Iqbal MM, Rahman A, Husain Z, et al. Clozapine: a clinical review of adverse effects and management. Ann Clin Psychiatry 2003; 15: 33-48.


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