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Preventing all the complications of hyperglycaemia: not a straightforward task

Aidan McElduff
Med J Aust 2016; 205 (4): 160-161. || doi: 10.5694/mja16.00726
Published online: 15 August 2016

Individualised multifactorial treatment strategies are required to optimise outcomes

Epidemiological studies have found positive relationships between measures of glycaemia and adverse fetal and maternal pregnancy outcomes,1 macrovascular disease2,3 and the microvascular complications of diabetes.2,3 The relationship between glycaemia and microvascular disease is more complicated, as there is an inflection point below which the risk is very low, but beyond which it rises sharply. The inflection point of the relationship between glycaemia values and the prevalence of retinopathy has been used to determine both the glucose tolerance test values and the glycated haemoglobin (HbA1c) level used to diagnose diabetes (see Figure 1 in reference 3).

  • Aidan McElduff

  • University of Sydney, Sydney, NSW


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