Compliance with Australian splenectomy guidelines in patients undergoing post-traumatic splenectomy at a tertiary centre

Ravindra Dotel, Iain B Gosbell and Ann Hofmeyr
Med J Aust 2015; 202 (5): 240-241. || doi: 10.5694/mja14.01643

To the Editor: The lack of a functioning spleen is associated with a lifelong risk of overwhelming post-splenectomy infection (OPSI). Historically, mortality rates associated with OPSI have been in excess of 50%.1-3 OPSI is a preventable illness through vaccination, education, prophylactic antibiotic use and other measures, as summarised in the national Australasian Society for Infectious Diseases (ASID)-endorsed guidelines for prevention of sepsis in asplenic and hyposplenic patients.4

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  • Ravindra Dotel1
  • Iain B Gosbell1,2
  • Ann Hofmeyr1

  • 1 Liverpool Hospital, Sydney, NSW.
  • 2 University of Western Sydney, Sydney, NSW.


Competing interests:

No relevant disclosures.

  • 1. Lynch AM, Kapila R. Overwhelming postsplenectomy infection. Infect Dis Clin North Am 1996; 10: 693-707.
  • 2. Davidson RN, Wall RA. Prevention and management of infections in patients without a spleen. Clin Microbiol Infect 2001; 7: 657-660.
  • 3. Evans DI. Postsplenectomy sepsis 10 years or more after operation. J Clin Pathol 1985; 38: 309-311.
  • 4. Spelman D, Buttery J, Daley A, et al. Guidelines for the prevention of sepsis in asplenic and hyposplenic patients. Intern Med J 2008; 38: 349-356.


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